Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF

• Published in: The Journal of clinical investigation Vol. 106; no. 12; pp. 1511 - 1519
• Main Authors: Nakamura, Teruya, Mizuno, Shinya, Matsumoto, Kunio, Sawa, Yoshiki, Matsuda, Hikaru, Nakamura, Toshikazu
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 15.12.2000
• Subjects: Animals; Antibodies - pharmacology; Apoptosis - drug effects; bcl-X Protein; Cell Survival - drug effects; Cells, Cultured; Disease Models, Animal; Hepatocyte Growth Factor - antagonists & inhibitors; Hepatocyte Growth Factor - metabolism; Hepatocyte Growth Factor - pharmacology; Histocytochemistry; Humans; Hydrogen Peroxide - pharmacology; Male; Mitogen-Activated Protein Kinases - antagonists & inhibitors; Mitogen-Activated Protein Kinases - metabolism; Myocardial Ischemia - enzymology; Myocardial Ischemia - metabolism; Myocardial Ischemia - pathology; Myocardial Reperfusion Injury - enzymology; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocardium - enzymology; Myocardium - metabolism; Myocardium - pathology; Proto-Oncogene Proteins c-bcl-2 - metabolism; Proto-Oncogene Proteins c-met - metabolism; Rats; Rats, Sprague-Dawley; Recombinant Proteins - pharmacology

Using a rat model of ischemia/reperfusion injury, we demonstrate here that HGF is cardioprotective due to its antiapoptotic effect on cardiomyocytes. Following transient myocardial ischemia and reperfusion, c-Met/HGF receptor expression rapidly increased in the ischemic myocardium, an event accompan...