Twelve weeks of exenatide treatment increases [18F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males

• Published in: Metabolism, clinical and experimental Vol. 106; p. 154167
• Main Authors: Janssen, Laura G.M., Nahon, Kimberly J., Bracké, Katrien F.M., van den Broek, Dennis, Smit, Renée, Sardjoe Mishre, Aashley S.D., Koorneef, Lisa L., Martinez-Tellez, Borja, Burakiewicz, Jedrzej, Kan, Hermien E., van Velden, Floris H.P., Pereira Arias-Bouda, Lenka M., de Geus-Oei, Lioe-Fee, Berbée, Jimmy F.P., Jazet, Ingrid M., Boon, Mariëtte R., Rensen, Patrick C.N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2020
• Subjects: [18F]FDG-PET/CT; Brown adipose tissue; Glucagon-like peptide-1 receptor agonism; Lipid metabolism; MRI; Weight loss; [18F]FDG; GLP-1; MRI; Weight loss; VAS; Brown adipose tissue; Glucagon-like peptide-1 receptor agonism; SUVpeak; REE; BAT; PET/CT; [18F]FDG-PET/CT; SUVmean; Lipid metabolism; GLP-1R; [F]FDG-PET/CT

Brown adipose tissue (BAT) improves energy metabolism by combusting glucose and lipids into heat. Agonism of the glucagon-like peptide-1 receptor (GLP-1R) within the central nervous system activates BAT in mice. Moreover, in patients with type 2 diabetes, GLP-1R agonism lowers body weight and improv...