Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology

• Published in: Trends in neurosciences (Regular ed.) Vol. 42; no. 5; pp. 349 - 360
• Main Authors: George, David T., Ameli, Rezvan, Koob, George F.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2019
• Subjects: addiction; depression; intermittent explosive disorder; pain; survival; pain; depression; intermittent explosive disorder; addiction; survival

Neurons in the periaqueductal gray (PAG) integrate negative emotions with the autonomic, neuroendocrine, and immune systems to facilitate responses to threat. Modern functional track tracing in animals and optogenetic and chemogenetic techniques show that the PAG is a rich substrate for the integrat...