Early pharmacological profiling of isatin derivatives as potent and selective cytotoxic agents

• Published in: Biochemical pharmacology Vol. 222; p. 116059
• Main Authors: Puerta, Adrián, González-Bakker, Aday, Brandão, Pedro, Pineiro, Marta, Burke, Anthony J., Giovannetti, Elisa, Fernandes, Miguel X., Padrón, José M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.04.2024
• Subjects: Antineoplastic Agents - pharmacology; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chemistry; Cytotoxins; Drug Screening Assays, Antitumor; Humans; Isatin; Isatin - pharmacology; Kemi; Live cell imaging; Lung Neoplasms; Molecular Structure; Necroptosis; Non-small cell lung cancer; Structure-Activity Relationship; Necroptosis; Isatin; Live cell imaging; Non-small cell lung cancer

[Display omitted] Isatin derivatives have attracted a lot of interest for their potential in the development of new anticancer drugs. A library of 38 isatin derivatives, created through an Ugi four-component reaction, underwent an initial screening in a panel of six human solid tumor cell lines. The...