Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

• Published in: Cell stem cell Vol. 18; no. 5; pp. 587 - 590
• Main Authors: Tang, Hengli, Hammack, Christy, Ogden, Sarah C., Wen, Zhexing, Qian, Xuyu, Li, Yujing, Yao, Bing, Shin, Jaehoon, Zhang, Feiran, Lee, Emily M., Christian, Kimberly M., Didier, Ruth A., Jin, Peng, Song, Hongjun, Ming, Guo-li
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.05.2016
• Subjects: Cell Cycle; Cell Death; Cell Proliferation; Flavivirus; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells - virology; Neural Stem Cells - pathology; Neural Stem Cells - virology; Zika virus; Zika Virus - physiology; Zika Virus Infection - pathology; Zika Virus Infection - virology

The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain of the ZIKV, MR766, serially passaged in monkey and mosqui...