Blood-brain barrier permeability during dopamine-induced hypertension in fetal sheep

• Published in: Journal of applied physiology (1985) Vol. 91; no. 1; pp. 123 - 129
• Main Authors: Harris, Andrew P, Robinson, Roderick, Koehler, Raymond C, Traystman, Richard J, Gleason, Christine A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.07.2001; American Physiological Society
• Subjects: Acids; Aminoisobutyric Acids - administration & dosage; Aminoisobutyric Acids - blood; Animals; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure; Blood-Brain Barrier; Brain; Brain - embryology; Capillary Permeability; Cardiology. Vascular system; Dopamine; Dose-Response Relationship, Drug; Experimental diseases; Fetus - physiology; Fetuses; Hypertension; Hypertension - chemically induced; Hypertension - metabolism; Hypertension - physiopathology; Medical sciences; Neurology; Permeability; Sheep; Sheep - embryology; Water content; Hypertension; Edema; Cardiovascular disease; Permeability; Blood brain barrier; Gestational age; Fetal diseases; Vertebrata; Experimental disease; Mammalia; Animal; Central nervous system disease; Fetus; Sheep; Developmental stage; Artiodactyla; Ungulata; Brain (vertebrata)

Departments of 1  Anesthesiology/Critical Care Medicine and 2  Pediatrics, The Johns Hopkins University, Baltimore, Maryland 21287; and 3  Department of Pediatrics, University of Washington, Seattle, Washington 98195 Dopamine is often used as a pressor agent in sick newborn infants, but an increase...