Identification of genomic-wide genetic links between cutaneous melanoma and obesity-related physical traits via cFDR

• Published in: Genes & genomics Vol. 45; no. 12; pp. 1549 - 1562
• Main Authors: Lin, Shen, Shen, Runnan, Huang, Jingqian, Liu, Yanhan, Li, Hongpeng, Xu, Qingfang
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.12.2023; Springer; Springer Nature B.V; 한국유전학회
• Subjects: Animal Genetics and Genomics; Biomedical and Life Sciences; Cell cycle; cell senescence; Cholesterol; Comorbidity; cytokines; Epidemiology; gene ontology; Genes; Genetic aspects; genetic correlation; Genetic Predisposition to Disease; genome; Genome-Wide Association Study; Genomics; glucose; Human Genetics; Humans; Keratinocytes; Life Sciences; Lipid metabolism; Medical colleges; Medical research; Medicine, Experimental; Meiosis; Melanoma; Melanoma - genetics; Melanoma, Cutaneous Malignant; metabolism; Microbial Genetics and Genomics; Nuclear division; Obesity; Obesity - genetics; Paracrine signalling; pathogenesis; Physiological aspects; Plant Genetics and Genomics; Quantitative genetics; Quantitative Trait Loci; quantitative traits; Research Article; risk; Senescence; Sequence analysis; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Skin Neoplasms - genetics; Type 2 diabetes; 생물학; Obesity; Pleiotropy; Cutaneous melanoma; Conditional false discovery rate

Background Both epidemiological and clinical studies have suggested the comorbidity between cutaneous melanoma (CM) and obesity-related physical traits. However, it remains unclear about their shared genetic architecture. Objective To determine the shared genetic architecture between CM and obesity-...