Impact of supervised exercise on skeletal muscle blood flow and vascular function measured with MRI in patients with peripheral artery disease

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 323; no. 3; pp. H388 - H396
• Main Authors: Englund, Erin K., Langham, Michael C., Wehrli, Felix W., Fanning, Molly J., Khan, Zeeshan, Schmitz, Kathryn H., Ratcliffe, Sarah J., Floyd, Thomas F., Mohler, Emile R.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.09.2022
• Series: New Developments in Translational Microcirculatory Research
• Subjects: Ankle; Blood flow; Cardiovascular diseases; Exercise Test; Exercise Therapy; Health care; Health services; Humans; Hyperemia; Hyperemia - diagnostic imaging; Intermittent Claudication - diagnostic imaging; Intermittent Claudication - therapy; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Metabolism; Microvasculature; Muscle, Skeletal - blood supply; Muscles; Musculoskeletal system; Oxygen; Oxygen content; Oxygen saturation; Oxygenation; Patients; Perfusion; Peripheral Arterial Disease - diagnostic imaging; Peripheral Arterial Disease - therapy; Regional Blood Flow; Skeletal muscle; Treadmills; Vascular diseases; Vein & artery diseases; Walking; vascular function; magnetic resonance imaging; exercise therapy; peripheral artery disease; microcirculation
• ISSN: 0363-6135; 1522-1539; 1522-1539
• DOI: 10.1152/ajpheart.00633.2021

Supervised exercise interventions can improve symptomatology in patients with peripheral artery disease, but the underlying mechanism remains unclear. Here, MRI was used to evaluate perfusion, relative tissue oxygenation, and venous oxygen saturation in response to cuff-induced ischemia. Reactive hy...