Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells

To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AH...

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Published inYonsei medical journal Vol. 61; no. 1; pp. 100 - 102
Main Authors Leem, Galam, Kim, Beom Kyung, Shin, Eui-Cheol, Park, Jun Yong
Format Journal Article
LanguageEnglish
Published Korea (South) Yonsei University College of Medicine 01.01.2020
연세대학교의과대학
Subjects
Aged
Brief Communication
Female
Hepatitis A - complications
Hepatitis A - immunology
Hepatitis A - physiopathology
Hepatitis, Autoimmune - etiology
Hepatitis, Autoimmune - immunology
Hepatitis, Autoimmune - physiopathology
Humans
Inflammation - pathology
Liver - pathology
Liver - physiopathology
Liver Failure - etiology
Liver Failure - immunology
Liver Failure - pathology
Liver Failure - physiopathology
Liver Function Tests
T-Lymphocytes, Regulatory - immunology
의학일반
regulatory T cells
Autoimmune hepatitis
acute hepatitis A
inflammatory conversion of Treg cells
Online AccessGet full text
ISSN0513-5796
1976-2437
1976-2437
DOI10.3349/ymj.2020.61.1.100

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Abstract To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
AbstractList To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, weperformed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantationdue to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remainedhigh for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells intomediators of inflammation may have played a role in the autoimmune pathogenesis following AHA. KCI Citation Count: 0
To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
Author Kim, Beom Kyung
Shin, Eui-Cheol
Leem, Galam
Park, Jun Yong
AuthorAffiliation 2 Department of Internal Medicine, Yonsei University College of Medicine, Yonsei Liver Center, Severance Hospital, Seoul, Korea
1 Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea
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Issue 1
Keywords regulatory T cells
Autoimmune hepatitis
acute hepatitis A
inflammatory conversion of Treg cells
Language English
License Copyright: Yonsei University College of Medicine 2020.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, weperformed multi-color flow cytometry...
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SubjectTerms Aged
Brief Communication
Female
Hepatitis A - complications
Hepatitis A - immunology
Hepatitis A - physiopathology
Hepatitis, Autoimmune - etiology
Hepatitis, Autoimmune - immunology
Hepatitis, Autoimmune - physiopathology
Humans
Inflammation - pathology
Liver - pathology
Liver - physiopathology
Liver Failure - etiology
Liver Failure - immunology
Liver Failure - pathology
Liver Failure - physiopathology
Liver Function Tests
T-Lymphocytes, Regulatory - immunology
의학일반
Title Autoimmune Hepatic Failure Following Acute Hepatitis A is Accompanied by Inflammatory Conversion of Regulatory T Cells
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