Can small nucleolar RNA be a novel molecular target for hepatocellular carcinoma?

• Published in: Gene Vol. 733; p. 144384
• Main Authors: Shuwen, Han, Xi, Yang, Quan, Qi, Yin, Jin, Miao, Da
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.04.2020
• Subjects: Antineoplastic Agents - therapeutic use; carcinogenesis; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; cells; correlation; death; Gene Expression Regulation, Neoplastic; genes; Hepatocellular carcinoma; hepatoma; Humans; literature; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Molecular Targeted Therapy; occurrence; Prognosis; RNA; RNA, Small Nucleolar - antagonists & inhibitors; RNA, Small Nucleolar - genetics; screening; signal transduction; Small nucleolar host gene; Small nucleolar RNA; tissues; Hepatocellular carcinoma; Small nucleolar RNA; Small nucleolar host gene
• DOI: 10.1016/j.gene.2020.144384
• ISSN: 0378-1119; 1879-0038

•We reviewed the related literature of small nucleolar RNAs and small nucleolar RNA host genes in hepatocellular carcinoma.•We constructed the regulatory network with regard to hepatocellular carcinoma related small nucleolar RNAs and small nucleolar RNA host genes.•Some snoRNAs and SNHGs regulate the occurrence and development of hepatocellular carcinoma by modulating epithelial-mesenchymal transition and Wnt/β-catenin signaling pathway. Globally, hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. Recently, many studies have demonstrated that small nucleolar RNA (snoRNA) was closely related to HCC. To explore whether snoRNA can be used as a molecular target for HCC. The PubMed, Embase, and Cochrane databases were searched for the published literatures related to snoRNA and HCC until August 12, 2019. After identification, screening, and verification, this study finally included 26 studies correlating small nucleolar RNA host gene (SNHG) and HCC, and 8 studies correlating snoRNA and HCC. Based on the collation of the relevant literature, the correlation network diagram between snoRNAs and HCC was constructed. The SNHGs, such as SNHG1, SNHG6, SNHG16, and SNHG20 can play varied roles in HCC through different regulatory mechanisms. These SNHGs can promote and inhibit tumorigenesis. SNORD76 can promote the proliferation of tumor tissues and cells in vitro through different pathways. SnoU2_19 and SNORD76 can function through the same pathway. SNHG3, SNHG20, SNHG6, SNORD76, and snoRA47 can modulate epithelial-mesenchymal transition (EMT) to regulate the development of HCC cell or tissue. SNHG16, SNORD76, and SnoU2_19 can regulate the development of HCC through Wnt/β-catenin signaling pathway. snoRNA can regulate the occurrence of HCC by modulating multiple molecular signaling pathways. Hence, snoRNA can be a potential molecular target for HCC.