Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging

• Published in: American journal of physiology. Renal physiology Vol. 319; no. 5; pp. F754 - F764
• Main Authors: Tahaei, Ebrahim, Coleman, Richard, Saritas, Turgay, Ellison, David H., Welling, Paul A.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2020
• Subjects: Animals; Diuretics; Diuretics - metabolism; Female; Furosemide; Gender differences; Imaging, Three-Dimensional - methods; Kidney Tubules, Distal - diagnostic imaging; Kidney Tubules, Distal - metabolism; Kidneys; Male; Mice; Phosphorylation; Rodents; Sex Characteristics; Sex differences; Sexual dimorphism; Sodium - metabolism; Sodium Chloride Symporter Inhibitors - metabolism; remodeling; three-dimensional; sodium-chloride cotransporter; sexual dimorphism

The thiazide-sensitive Na + -Cl − cotransporter (NCC) is more abundant in kidneys of female subjects than of male subjects. Because morphological remodeling of the distal convoluted tubule (DCT) is dependent on NCC activity, it has been generally assumed that there is a corresponding sexual dimorphi...