Acute lysyl oxidase inhibition alters microvascular function in normotensive but not hypertensive men and women

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 314; no. 3; pp. H424 - H433
• Main Authors: Craighead, Daniel H., Wang, Huilei, Santhanam, Lakshmi, Alexander, Lacy M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2018
• Series: Extracellular Matrix in Cardiovascular Pathophysiology
• Subjects: Adult; Age; Amino Acid Oxidoreductases - antagonists & inhibitors; Amino Acid Oxidoreductases - metabolism; Aminopropionitrile - administration & dosage; Blood Pressure; Collagen; Conductance; Cross-linking; Crosslinking; Doppler effect; Enzyme Inhibitors - administration & dosage; Erythrocytes; Extracellular matrix; Female; Fibers; Forearm; Humans; Hypertension; Hypertension - diagnosis; Hypertension - physiopathology; Inhibition; Liquid oxygen; Lysyl oxidase; Male; Matrix; Men; Microcirculation - drug effects; Microdialysis; Microvasculature; Microvessels - drug effects; Microvessels - enzymology; Microvessels - physiopathology; Middle Aged; Muscles; Norepinephrine; Oxidase; Protein-Lysine 6-Oxidase - antagonists & inhibitors; Protein-Lysine 6-Oxidase - metabolism; Skin; Skin - blood supply; Smooth muscle; Sodium; Sodium nitroprusside; Stability; Stability analysis; Stiffness; Vasoconstriction - drug effects; Vasodilation - drug effects; Women; Young Adult; lysyl oxidase; microvascular; hypertension

The lysyl oxidase (LOX) family of enzymes regulates collagen cross-linking. LOX is upregulated in hypertension, increasing vascular stiffness. In vivo human research is sparse, as long-term LOX inhibition in animals causes vascular instability. Our aim was to evaluate the effects of LOX inhibition o...