The Fire Within: Microbes Inflame Tumors

• Published in: Cell Vol. 157; no. 4; pp. 776 - 783
• Main Authors: Gagliani, Nicola, Hu, Bo, Huber, Samuel, Elinav, Eran, Flavell, Richard A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.05.2014
• Subjects: Gastroenteritis - immunology; Gastroenteritis - microbiology; homeostasis; Humans; immune system; Immunity, Innate; inflammation; Intestinal Neoplasms - immunology; Intestinal Neoplasms - microbiology; intestines; Microbiota; microorganisms; neoplasms; Th17 Cells - immunology; Toll-Like Receptors - immunology

The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions...