The Fire Within: Microbes Inflame Tumors

The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions...

Full description

Saved in:
Bibliographic Details
Published inCell Vol. 157; no. 4; pp. 776 - 783
Main Authors Gagliani, Nicola, Hu, Bo, Huber, Samuel, Elinav, Eran, Flavell, Richard A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 08.05.2014
Subjects
Gastroenteritis - immunology
Gastroenteritis - microbiology
homeostasis
Humans
immune system
Immunity, Innate
inflammation
Intestinal Neoplasms - immunology
Intestinal Neoplasms - microbiology
intestines
Microbiota
microorganisms
neoplasms
Th17 Cells - immunology
Toll-Like Receptors - immunology
Online AccessGet full text

Cover

More Information
Summary:The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions between the microbiota and the innate and adaptive immune systems and discuss their potential to lead us in new directions for understanding cancer biology and treatment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2014.03.006