The Fire Within: Microbes Inflame Tumors
The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions...
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| Published in | Cell Vol. 157; no. 4; pp. 776 - 783 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
08.05.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions between the microbiota and the innate and adaptive immune systems and discuss their potential to lead us in new directions for understanding cancer biology and treatment. |
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| AbstractList | The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions between the microbiota and the innate and adaptive immune systems and discuss their potential to lead us in new directions for understanding cancer biology and treatment. The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions between the microbiota and the innate and adaptive immune systems and discuss their potential to lead us in new directions for understanding cancer biology and treatment.The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development. We review recent advances in understanding the complex interactions between the microbiota and the innate and adaptive immune systems and discuss their potential to lead us in new directions for understanding cancer biology and treatment. |
| Author | Gagliani, Nicola Elinav, Eran Huber, Samuel Hu, Bo Flavell, Richard A. |
| Author_xml | – sequence: 1 givenname: Nicola surname: Gagliani fullname: Gagliani, Nicola organization: Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA – sequence: 2 givenname: Bo surname: Hu fullname: Hu, Bo organization: Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA – sequence: 3 givenname: Samuel surname: Huber fullname: Huber, Samuel organization: I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, Hamburg, Germany – sequence: 4 givenname: Eran surname: Elinav fullname: Elinav, Eran organization: Immunology Department, Weizmann Institute of Science, Rehovot 76100, Israel – sequence: 5 givenname: Richard A. surname: Flavell fullname: Flavell, Richard A. email: richard.flavell@yale.edu organization: Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24813605$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Gastroenteritis - immunology Gastroenteritis - microbiology homeostasis Humans immune system Immunity, Innate inflammation Intestinal Neoplasms - immunology Intestinal Neoplasms - microbiology intestines Microbiota microorganisms neoplasms Th17 Cells - immunology Toll-Like Receptors - immunology |
| Title | The Fire Within: Microbes Inflame Tumors |
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