Evaluation of renal and cardiovascular protection mechanisms of SGLT2 inhibitors: model-based analysis of clinical data

• Published in: American journal of physiology. Renal physiology Vol. 315; no. 5; pp. F1295 - F1306
• Main Authors: Hallow, K. Melissa, Greasley, Peter J., Helmlinger, Gabriel, Chu, Lulu, Heerspink, Hiddo J., Boulton, David W.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2018
• Subjects: Antihypertensives; Benzhydryl Compounds - therapeutic use; Blood pressure; Cardiovascular system; Cardiovascular System - drug effects; Cardiovascular System - metabolism; Cardiovascular System - physiopathology; Clinical trials; Computer Simulation; Creatinine; Data processing; Diabetes mellitus; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diuresis; Diuresis - drug effects; Excretion; Glomerular filtration rate; Glomerular Filtration Rate - drug effects; Glucose; Glucosides - therapeutic use; Heart Failure - drug therapy; Heart Failure - etiology; Heart Failure - metabolism; Heart Failure - physiopathology; Hemodynamics; Hemodynamics - drug effects; Homeostasis; Humans; Kidney - drug effects; Kidney - metabolism; Kidney - physiopathology; Mathematical models; Models, Cardiovascular; Monitoring systems; Na+/glucose cotransporter; Na+/H+-exchanging ATPase; Plasma; Reabsorption; Renal function; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - physiopathology; Renal Reabsorption - drug effects; Sodium; Sodium-Glucose Transporter 1 - metabolism; Sodium-Glucose Transporter 2 - metabolism; Sodium-Glucose Transporter 2 Inhibitors - therapeutic use; Treatment Outcome; heart failure; renal function; chronic kidney disease; computational modeling; SGLT2 inhibition

The mechanisms of cardiovascular and renal protection observed in clinical trials of sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) are incompletely understood and likely multifactorial, including natriuretic, diuretic, and antihypertensive effects, glomerular pressure reduction, and low...