Increased urinary angiotensin converting enzyme 2 and neprilysin in patients with type 2 diabetes

• Published in: American journal of physiology. Renal physiology Vol. 315; no. 2; pp. F263 - F274
• Main Authors: Gutta, Sridevi, Grobe, Nadja, Kumbaji, Meenasri, Osman, Hassan, Saklayen, Mohammad, Li, Gengxin, Elased, Khalid M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2018
• Subjects: ACE inhibitors; ACE2; ADAM protein; ADAM17 Protein - urine; Adult; Aged; Albuminuria - enzymology; Albuminuria - etiology; Albuminuria - physiopathology; Albuminuria - urine; Angiotensin; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Biomarkers - urine; Case-Control Studies; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - enzymology; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - urine; Diabetic Nephropathies - enzymology; Diabetic Nephropathies - etiology; Diabetic Nephropathies - physiopathology; Diabetic Nephropathies - urine; Enzyme-linked immunosorbent assay; Female; Glomerular Filtration Rate; Humans; Kidney - enzymology; Kidney - physiopathology; Kidney diseases; Kidney transplantation; Male; Middle Aged; Neprilysin; Neprilysin - urine; Peptidyl-Dipeptidase A - urine; Predictive Value of Tests; Proximal tubules; Up-Regulation; NEP; ACE2; ADAM17; chronic kidney disease; type 2 diabetes; diabetic nephropathy

Angiotensin converting enzyme 2 (ACE2) and neprilysin (NEP) are metalloproteases that are highly expressed in the renal proximal tubules. ACE2 and NEP generate renoprotective angiotensin (1–7) from angiotensin II and angiotensin I, respectively, and therefore could have a major role in chronic kidne...