Cytokines Involved in the Systemic Inflammatory Response Induced by Exposure to Particulate Matter Air Pollutants (PM10)

• Published in: American journal of respiratory and critical care medicine Vol. 164; no. 5; pp. 826 - 830
• Main Authors: van EEDEN, STEPHAN F, TAN, WAN C, SUWA, TATSUSHI, MUKAE, HIROSHI, TERASHIMA, TAKESHI, FUJII, TAKESHI, QUI, DIWEN, VINCENT, RENAUD, HOGG, JAMES C
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 01.09.2001; American Lung Association
• Subjects: Aged; Air Pollutants - adverse effects; Biological and medical sciences; Cytokines - blood; Cytokines - physiology; Female; Humans; Inflammation - blood; Inflammation - chemically induced; Inflammation - immunology; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Particle Size; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Respiratory system; Human; Lung disease; Pathophysiology; Respiratory disease; Toxicity; Cytokine; Exploration; Inflammation; Interleukin 6; Lung function; Pulmonary alveolus; Air pollution; Macrophage

Elevated levels of ambient particulate matter (PM(10)) have been associated with increased cardiopulmonary morbidity and mortality. We previously showed that the deposition of particles in the lung induces a systemic inflammatory response that includes stimulation of the bone marrow. This marrow res...