The Effect of Therapeutic Drug Monitoring on Safety and Efficacy of Voriconazole in Invasive Fungal Infections: A Randomized Controlled Trial

• Published in: Clinical infectious diseases Vol. 55; no. 8; pp. 1080 - 1087
• Main Authors: Park, Wan Beom, Kim, Nak-Hyun, Kim, Kye-Hyung, Lee, Seung Hwan, Nam, Won-Seok, Yoon, Seo Hyun, Song, Kyoung-Ho, Choe, Pyoeng Gyun, Kim, Nam Joong, Jang, In-Jin, Oh, Myoung-don, Yu, Kyung-Sang
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.10.2012
• Subjects: Adult; Aged; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - adverse effects; Antifungal Agents - therapeutic use; ARTICLES AND COMMENTARIES; Aryl Hydrocarbon Hydroxylases - genetics; Aspergillosis - drug therapy; Aspergillosis - enzymology; Aspergillosis - genetics; Biological and medical sciences; Blood; Chi-Square Distribution; Clinical trials; Correlation analysis; Cytochrome P-450 CYP2C19; Dosage; Drug dosages; Drug monitoring; Drug Monitoring - statistics & numerical data; Encephalopathies; Enzymes; Female; Fungal infections; Genotype & phenotype; Humans; Infectious diseases; Male; Medical sciences; Medical treatment; Medical treatment failures; Metabolism; Middle Aged; Pharmacology. Drug treatments; Prospective Studies; Pyrimidines - adverse effects; Pyrimidines - blood; Pyrimidines - therapeutic use; Shooting ranges; Single-Blind Method; Treatment Outcome; Triazoles - adverse effects; Triazoles - blood; Triazoles - therapeutic use; Voriconazole; Infection; Therapeutic drug monitoring; Antifungal agent; Mycosis; Azole derivatives; Voriconazole; Triazole derivatives; Pharmacokinetics

Background. Blood levels of voriconazole, a first line therapy for invasive aspergillosis, may correlate with adverse events and treatment response. However, no randomized controlled studies have been conducted to evaluate the clinical utility of routine therapeutic drug monitoring (TDM) of voricona...