Genetic and biological hallmarks of colorectal cancer

• Published in: Genes & development Vol. 35; no. 11-12; pp. 787 - 820
• Main Authors: Li, Jiexi, Ma, Xingdi, Chakravarti, Deepavali, Shalapour, Shabnam, DePinho, Ronald A.
• Format: Journal Article
• Language: English
• Published: Cold Spring Harbor Laboratory Press 01.06.2021
• Subjects: Review

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to under...