Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 34; no. 1; pp. 154 - 158
• Main Authors: Kajizuka, Masanobu, Miyachi, Taishi, Matsuzaki, Hideo, Iwata, Keiko, Shinmura, Chie, Suzuki, Katsuaki, Suda, Shiro, Tsuchiya, Kenji J., Matsumoto, Kaori, Iwata, Yasuhide, Nakamura, Kazuhiko, Tsujii, Masatsugu, Sugiyama, Toshiro, Takei, Nori, Mori, Norio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.02.2010; Elsevier
• Subjects: Adolescent; Autism; Autistic Disorder - blood; Autistic Disorder - physiopathology; Biological and medical sciences; Case-Control Studies; Child; Child clinical studies; Developmental disorders; ELISA; Enzyme-Linked Immunosorbent Assay - methods; Human serum; Humans; Infantile autism; Linear Models; Male; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Platelet-derived growth factor; Platelet-Derived Growth Factor - metabolism; Protein Structure, Tertiary; Proto-Oncogene Proteins c-sis; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Serum - metabolism; Severity of Illness Index; Stereotyped Behavior - physiology; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - blood; Young Adult; Human serum; Platelet-derived growth factor; BDNF; EGF; VEGF; HGF; IQ; SCID; SD; Autism; WAIS-R; PDGF; ADI-R; TGF-β1; MCP; Vascular endothelial growth factor; ELISA; Human; Biological fluid; Male; Developmental disorder; Enzyme immunoassay; Vascular endothelium growth factor; Serum; Child; ELISA assay; Platelet derived growth factor

The neurobiological basis of autism remains poorly understood. To examine the role played by serum cytokines in brain development, we hypothesized that Platelet-Derived Growth Factor (PDGF) and Vascular Endothelial Growth Factor (VEGF) may be associated with pathophysiology of autism. In this study,...