Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 314; no. 2; pp. H343 - H349
• Main Authors: Alba, Billie K., Greaney, Jody L., Ferguson, Sara B., Alexander, Lacy M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.02.2018
• Series: Vascular Biology and Microcirculation
• Subjects: Adrenergic receptors; Adult; Adults; Antioxidants; Arginine; Ascorbic acid; Bioavailability; Blood flow; Blood Flow Velocity; Cardiovascular diseases; Case-Control Studies; Conductance; Doppler effect; Endothelium; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Female; Fibers; Forearm; Health risks; Humans; Laser beam heating; Male; Microcirculation; Microdialysis; Microvasculature; Microvessels - metabolism; Microvessels - physiopathology; NG-Nitroarginine methyl ester; Nitric oxide; Nitric Oxide - metabolism; Nitric-oxide synthase; Norepinephrine; Oxidative Stress; Patients; Perfusion; Psoriasis; Psoriasis - diagnosis; Psoriasis - metabolism; Psoriasis - physiopathology; Regional Blood Flow; Risk factors; Signal Transduction; Skin; Skin - blood supply; Vasoconstriction; Vasodilation; Veins & arteries; nitric oxide; vasodilation; microcirculation; psoriasis; oxidative stress

Psoriasis is an independent risk factor for cardiovascular disease; however, the underlying mechanisms are not fully understood. Deficits in conduit arterial function are evident in patients with psoriasis, but potential impairments in microcirculatory endothelial function remain unclear. We hypothe...