Complete genome sequence and bioinformatics analysis of nine Egyptian females with clinical information from different geographic regions in Egypt

• Published in: Gene Vol. 769; p. 145237
• Main Authors: ElHefnawi, Mahmoud, Hegazy, Elsayed, Elfiky, Asmaa, Jeon, Yeonsu, Jeon, Sungwon, Bhak, Jong, Mohamed Metwally, Fateheya, Sugano, Sumio, Horiuchi, Terumi, Kazumi, Abe, Blazyte, Asta
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.02.2021
• Subjects: Adult; bioinformatics; Computational Biology; DNA, Mitochondrial - genetics; Egypt; environmental factors; Eurasia; Female; females; genes; Genome, Human; genomics; Humans; immigration; information; Middle Aged; mutation; obesity; Personal genome; Phylogeography; Polymorphism, Single Nucleotide; precision medicine; sample size; sampling; Variant analysis; Whole Genome Sequencing; Egypt; Eurasia; WGS; GWAS; EGY; rCRS; CPEO; VEST; Variant analysis; NGS; Personal genome

•We reported and analyzed the whole genomes of nine Egyptian females from different regions.•A total 12 SNPs were shared in most of subjects.•mtDNA mutation A4282G was common in all subjects.•Both mtDNA and admixture analyses showed that Egyptians sharing genetic signature and metabolic phenotypes w...