FTVI promotes osteogenic differentiation of bone marrow mesenchymal stem cells through LncRNA HIF1A-AS2

• Published in: Journal of orthopaedic surgery and research Vol. 20; no. 1; pp. 548 - 10
• Main Authors: Xiao, Fei, Wang, Zidan, Cheng, Keke, Xing, Haiyuan, Lei, Tianrun, Wang, Junwen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.05.2025; BMC
• Subjects: Animals; Bone Marrow Cells - cytology; Cell Differentiation - genetics; Cell Differentiation - physiology; Cells, Cultured; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Male; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mesenchymal Stem Cells - physiology; Osteogenesis - genetics; Osteogenesis - physiology; Rats; Rats, Sprague-Dawley; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Long Noncoding - physiology; Stem cells

The treatment of bone defects caused by trauma and pathological factors was a common problem in clinic. Extracorporeal fucosylation has been proved to promote osteogenic differentiation. Nevertheless, the biological processes by which they promote osteogenesis are currently poorly understood. Long n...