Rehydration during exercise prevents the increase of homocysteine concentrations

This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydrat...

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Published in	Amino acids Vol. 51; no. 2; pp. 193 - 204
Main Authors	Maroto-Sánchez, Beatriz, Lopez-Torres, Olga, Valtueña, Jara, Benito, Pedro J., Palacios, Gonzalo, Díaz-Martínez, Ángel Enrique, González-Lamuño, Domingo, Zinellu, Angelo, González-Gross, Marcela, Carru, Ciriaco
Format	Journal Article
Language	English
Published	Vienna Springer Vienna 01.02.2019 Springer Nature B.V
Subjects	Adults Analytical Chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences blood serum Creatine Creatinine Data processing Drinking water Exercise exercise test Folic acid genotype Genotypes Homocysteine Life Sciences Males Metabolism Methylenetetrahydrofolate reductase Neurobiology Original Article Physical fitness Proteomics protocols Reductases Rehydration Sports drinks Vitamin B12 Hydration Homocysteine Metabolism Vitamins
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ISSN	0939-4451 1438-2199 1438-2199
DOI	10.1007/s00726-018-2655-y

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Abstract	This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise (NH1 and NH2), one with rehydration during exercise using water (H1) and one with rehydration during exercise using an isotonic sports drink (H2). After finishing the exercise tests, subjects followed a rehydration protocol for 2 h. Serum tHcy, vitamin B12, folate, creatine and creatinine were analysed before, after and at 2, 6 and 24 h after exercise. Data were analysed with and without correcting for haemoconcentration to assess the changes in tHcy related. The methylenetetrahydrofolate reductase ( MTHFR ) 677TT genotype was also analysed. THcy (uncorrected by haemoconcentration) increased significantly after exercise ( P < 0.05) in the NH1 and NH2 tests [mean increase ± SD: 1.55 ± 0.33 (15.18%) and 1.76 ± 0.25 (17.69%) µmol/L, respectively], while no significant differences were found in the H1 and H2 tests [mean increase: 0.65 (6.29%) and 0.90 (8.69%) μmol/L, respectively]. The increase was partly due to haemoconcentration and partly due to the metabolism underlying acute exercise. THcy concentrations recovered to baseline after 24 h in all tests. In conclusion, adequate rehydration during acute aerobic exercise using either water or a sports drink maintains tHcy concentrations at baseline and for up to 2 h after exercise in physically active male adults and prevents further increases when compared to no rehydration.
AbstractList	This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise (NH1 and NH2), one with rehydration during exercise using water (H1) and one with rehydration during exercise using an isotonic sports drink (H2). After finishing the exercise tests, subjects followed a rehydration protocol for 2 h. Serum tHcy, vitamin B12, folate, creatine and creatinine were analysed before, after and at 2, 6 and 24 h after exercise. Data were analysed with and without correcting for haemoconcentration to assess the changes in tHcy related. The methylenetetrahydrofolate reductase ( MTHFR ) 677TT genotype was also analysed. THcy (uncorrected by haemoconcentration) increased significantly after exercise ( P < 0.05) in the NH1 and NH2 tests [mean increase ± SD: 1.55 ± 0.33 (15.18%) and 1.76 ± 0.25 (17.69%) µmol/L, respectively], while no significant differences were found in the H1 and H2 tests [mean increase: 0.65 (6.29%) and 0.90 (8.69%) μmol/L, respectively]. The increase was partly due to haemoconcentration and partly due to the metabolism underlying acute exercise. THcy concentrations recovered to baseline after 24 h in all tests. In conclusion, adequate rehydration during acute aerobic exercise using either water or a sports drink maintains tHcy concentrations at baseline and for up to 2 h after exercise in physically active male adults and prevents further increases when compared to no rehydration. This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise (NH1 and NH2), one with rehydration during exercise using water (H1) and one with rehydration during exercise using an isotonic sports drink (H2). After finishing the exercise tests, subjects followed a rehydration protocol for 2 h. Serum tHcy, vitamin B12, folate, creatine and creatinine were analysed before, after and at 2, 6 and 24 h after exercise. Data were analysed with and without correcting for haemoconcentration to assess the changes in tHcy related. The methylenetetrahydrofolate reductase (MTHFR) 677TT genotype was also analysed. THcy (uncorrected by haemoconcentration) increased significantly after exercise (P < 0.05) in the NH1 and NH2 tests [mean increase ± SD: 1.55 ± 0.33 (15.18%) and 1.76 ± 0.25 (17.69%) µmol/L, respectively], while no significant differences were found in the H1 and H2 tests [mean increase: 0.65 (6.29%) and 0.90 (8.69%) μmol/L, respectively]. The increase was partly due to haemoconcentration and partly due to the metabolism underlying acute exercise. THcy concentrations recovered to baseline after 24 h in all tests. In conclusion, adequate rehydration during acute aerobic exercise using either water or a sports drink maintains tHcy concentrations at baseline and for up to 2 h after exercise in physically active male adults and prevents further increases when compared to no rehydration. This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise (NH1 and NH2), one with rehydration during exercise using water (H1) and one with rehydration during exercise using an isotonic sports drink (H2). After finishing the exercise tests, subjects followed a rehydration protocol for 2 h. Serum tHcy, vitamin B12, folate, creatine and creatinine were analysed before, after and at 2, 6 and 24 h after exercise. Data were analysed with and without correcting for haemoconcentration to assess the changes in tHcy related. The methylenetetrahydrofolate reductase (MTHFR) 677TT genotype was also analysed. THcy (uncorrected by haemoconcentration) increased significantly after exercise (P < 0.05) in the NH1 and NH2 tests [mean increase ± SD: 1.55 ± 0.33 (15.18%) and 1.76 ± 0.25 (17.69%) µmol/L, respectively], while no significant differences were found in the H1 and H2 tests [mean increase: 0.65 (6.29%) and 0.90 (8.69%) μmol/L, respectively]. The increase was partly due to haemoconcentration and partly due to the metabolism underlying acute exercise. THcy concentrations recovered to baseline after 24 h in all tests. In conclusion, adequate rehydration during acute aerobic exercise using either water or a sports drink maintains tHcy concentrations at baseline and for up to 2 h after exercise in physically active male adults and prevents further increases when compared to no rehydration. This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise (NH1 and NH2), one with rehydration during exercise using water (H1) and one with rehydration during exercise using an isotonic sports drink (H2). After finishing the exercise tests, subjects followed a rehydration protocol for 2 h. Serum tHcy, vitamin B12, folate, creatine and creatinine were analysed before, after and at 2, 6 and 24 h after exercise. Data were analysed with and without correcting for haemoconcentration to assess the changes in tHcy related. The methylenetetrahydrofolate reductase (MTHFR) 677TT genotype was also analysed. THcy (uncorrected by haemoconcentration) increased significantly after exercise (P < 0.05) in the NH1 and NH2 tests [mean increase ± SD: 1.55 ± 0.33 (15.18%) and 1.76 ± 0.25 (17.69%) µmol/L, respectively], while no significant differences were found in the H1 and H2 tests [mean increase: 0.65 (6.29%) and 0.90 (8.69%) μmol/L, respectively]. The increase was partly due to haemoconcentration and partly due to the metabolism underlying acute exercise. THcy concentrations recovered to baseline after 24 h in all tests. In conclusion, adequate rehydration during acute aerobic exercise using either water or a sports drink maintains tHcy concentrations at baseline and for up to 2 h after exercise in physically active male adults and prevents further increases when compared to no rehydration.This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise (NH1 and NH2), one with rehydration during exercise using water (H1) and one with rehydration during exercise using an isotonic sports drink (H2). After finishing the exercise tests, subjects followed a rehydration protocol for 2 h. Serum tHcy, vitamin B12, folate, creatine and creatinine were analysed before, after and at 2, 6 and 24 h after exercise. Data were analysed with and without correcting for haemoconcentration to assess the changes in tHcy related. The methylenetetrahydrofolate reductase (MTHFR) 677TT genotype was also analysed. THcy (uncorrected by haemoconcentration) increased significantly after exercise (P < 0.05) in the NH1 and NH2 tests [mean increase ± SD: 1.55 ± 0.33 (15.18%) and 1.76 ± 0.25 (17.69%) µmol/L, respectively], while no significant differences were found in the H1 and H2 tests [mean increase: 0.65 (6.29%) and 0.90 (8.69%) μmol/L, respectively]. The increase was partly due to haemoconcentration and partly due to the metabolism underlying acute exercise. THcy concentrations recovered to baseline after 24 h in all tests. In conclusion, adequate rehydration during acute aerobic exercise using either water or a sports drink maintains tHcy concentrations at baseline and for up to 2 h after exercise in physically active male adults and prevents further increases when compared to no rehydration.
Author	Valtueña, Jara González-Lamuño, Domingo Zinellu, Angelo Palacios, Gonzalo Carru, Ciriaco Benito, Pedro J. Lopez-Torres, Olga González-Gross, Marcela Díaz-Martínez, Ángel Enrique Maroto-Sánchez, Beatriz
Author_xml	– sequence: 1 givenname: Beatriz surname: Maroto-Sánchez fullname: Maroto-Sánchez, Beatriz email: b.marotosanchez@gmail.com organization: ImFine Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid – sequence: 2 givenname: Olga surname: Lopez-Torres fullname: Lopez-Torres, Olga organization: ImFine Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid – sequence: 3 givenname: Jara surname: Valtueña fullname: Valtueña, Jara organization: ImFine Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid – sequence: 4 givenname: Pedro J. surname: Benito fullname: Benito, Pedro J. organization: LFE Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid – sequence: 5 givenname: Gonzalo surname: Palacios fullname: Palacios, Gonzalo organization: ImFine Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid, Institute of Health Carlos III, CIBERobn CB 12/03/30038 – sequence: 6 givenname: Ángel Enrique surname: Díaz-Martínez fullname: Díaz-Martínez, Ángel Enrique organization: AEPSAD. High Sports Council – sequence: 7 givenname: Domingo surname: González-Lamuño fullname: González-Lamuño, Domingo organization: Pediatric Division, Hospital universitario Marqués de Valdecilla-Universidad de Cantabria and Research Institute Valdecilla (IDIVAL) – sequence: 8 givenname: Angelo surname: Zinellu fullname: Zinellu, Angelo organization: Department of Biomedical Sciences, University of Sassari – sequence: 9 givenname: Marcela surname: González-Gross fullname: González-Gross, Marcela organization: ImFine Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid, Institute of Health Carlos III, CIBERobn CB 12/03/30038 – sequence: 10 givenname: Ciriaco orcidid: 0000-0002-6985-4907 surname: Carru fullname: Carru, Ciriaco email: carru@uniss.it organization: Department of Biomedical Sciences, University of Sassari, Quality Control Unit, Hospital University of Sassari (AOU)
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Snippet	This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related...
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SubjectTerms	Adults Analytical Chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences blood serum Creatine Creatinine Data processing Drinking water Exercise exercise test Folic acid genotype Genotypes Homocysteine Life Sciences Males Metabolism Methylenetetrahydrofolate reductase Neurobiology Original Article Physical fitness Proteomics protocols Reductases Rehydration Sports drinks Vitamin B12
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Title	Rehydration during exercise prevents the increase of homocysteine concentrations
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