Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape

Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolution of extreme survival states are unknown. To understand di...

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Published inCell Vol. 187; no. 13; pp. 3338 - 3356.e30
Main Authors Singh, Param Priya, Reeves, G. Adam, Contrepois, Kévin, Papsdorf, Katharina, Miklas, Jason W., Ellenberger, Mathew, Hu, Chi-Kuo, Snyder, Michael P., Brunet, Anne
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 20.06.2024
Subjects
aging
Animals
Biological Evolution
chromatin
comparative genomics
complex trait evolution
diapause
Diapause - genetics
drought
Embryo, Nonmammalian - metabolism
epigenetics
epigenomics
evolution
Female
Fish Proteins - genetics
Fundulidae - genetics
Fundulidae - metabolism
gene expression
Gene Expression Regulation, Developmental
genes
killifish
Killifishes - genetics
Killifishes - metabolism
lipid composition
lipid metabolism
Lipid Metabolism - genetics
lipidomics
Male
metabolomics
multiomics
species
suspended animation
metabolomics
diapause
suspended animation
epigenomics
killifish
aging
complex trait evolution
comparative genomics
epigenetics
lipidomics
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Abstract Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolution of extreme survival states are unknown. To understand diapause evolution, we performed integrative multi-omics (gene expression, chromatin accessibility, and lipidomics) in the embryos of multiple killifish species. We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism. Indeed, diapause shows a distinct lipid profile, with an increase in triglycerides with very-long-chain fatty acids. Our work suggests a mechanism for the evolution of complex adaptations and offers strategies to promote long-term survival by activating suspended animation programs in other species. [Display omitted] •Paralogs that specialize for expression in diapause are evolutionarily very ancient•The chromatin landscape at very ancient paralogs was recently rewired in diapause•Rewiring of the chromatin landscape reveals binding sites for key transcription factors•A central function affected by rewiring is lipid metabolism, which is unique in diapause The African turquoise killifish has an extreme form of diapause that lasts many months, even years. Comparing gene expression and chromatin states across species revealed gene duplicates and a shift in lipid metabolism as important contributors to the specialization of a diapause expression program, critical for long-term protection and survival.
AbstractList Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolution of extreme survival states are unknown. To understand diapause evolution, we performed integrative multi-omics (gene expression, chromatin accessibility, and lipidomics) in the embryos of multiple killifish species. We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism. Indeed, diapause shows a distinct lipid profile, with an increase in triglycerides with very-long-chain fatty acids. Our work suggests a mechanism for the evolution of complex adaptations and offers strategies to promote long-term survival by activating suspended animation programs in other species.
Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolution of extreme survival states are unknown. To understand diapause evolution, we performed integrative multi-omics (gene expression, chromatin accessibility, and lipidomics) in the embryos of multiple killifish species. We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism. Indeed, diapause shows a distinct lipid profile, with an increase in triglycerides with very-long-chain fatty acids. Our work suggests a mechanism for the evolution of complex adaptations and offers strategies to promote long-term survival by activating suspended animation programs in other species. [Display omitted] •Paralogs that specialize for expression in diapause are evolutionarily very ancient•The chromatin landscape at very ancient paralogs was recently rewired in diapause•Rewiring of the chromatin landscape reveals binding sites for key transcription factors•A central function affected by rewiring is lipid metabolism, which is unique in diapause The African turquoise killifish has an extreme form of diapause that lasts many months, even years. Comparing gene expression and chromatin states across species revealed gene duplicates and a shift in lipid metabolism as important contributors to the specialization of a diapause expression program, critical for long-term protection and survival.
Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolution of extreme survival states are unknown. To understand diapause evolution, we performed integrative multi-omics (gene expression, chromatin accessibility, and lipidomics) in the embryos of multiple killifish species. We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism. Indeed, diapause shows a distinct lipid profile, with an increase in triglycerides with very-long-chain fatty acids. Our work suggests a mechanism for the evolution of complex adaptations and offers strategies to promote long-term survival by activating suspended animation programs in other species.Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended development to survive a complete drought. However, the mechanisms underlying the evolution of extreme survival states are unknown. To understand diapause evolution, we performed integrative multi-omics (gene expression, chromatin accessibility, and lipidomics) in the embryos of multiple killifish species. We find that diapause evolved by a recent remodeling of regulatory elements at very ancient gene duplicates (paralogs) present in all vertebrates. CRISPR-Cas9-based perturbations identify the transcription factors REST/NRSF and FOXOs as critical for the diapause gene expression program, including genes involved in lipid metabolism. Indeed, diapause shows a distinct lipid profile, with an increase in triglycerides with very-long-chain fatty acids. Our work suggests a mechanism for the evolution of complex adaptations and offers strategies to promote long-term survival by activating suspended animation programs in other species.
Author Singh, Param Priya
Contrepois, Kévin
Hu, Chi-Kuo
Reeves, G. Adam
Papsdorf, Katharina
Snyder, Michael P.
Brunet, Anne
Miklas, Jason W.
Ellenberger, Mathew
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  givenname: G. Adam
  surname: Reeves
  fullname: Reeves, G. Adam
  organization: Department of Genetics, Stanford University, Stanford, CA, USA
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  givenname: Kévin
  surname: Contrepois
  fullname: Contrepois, Kévin
  organization: Department of Genetics, Stanford University, Stanford, CA, USA
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  surname: Papsdorf
  fullname: Papsdorf, Katharina
  organization: Department of Genetics, Stanford University, Stanford, CA, USA
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  surname: Miklas
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  organization: Department of Genetics, Stanford University, Stanford, CA, USA
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  surname: Hu
  fullname: Hu, Chi-Kuo
  organization: Department of Genetics, Stanford University, Stanford, CA, USA
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  givenname: Anne
  surname: Brunet
  fullname: Brunet, Anne
  email: abrunet1@stanford.edu
  organization: Department of Genetics, Stanford University, Stanford, CA, USA
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Cites_doi 10.1038/nmeth.2688
10.1016/j.tig.2016.06.006
10.1016/S0891-5849(98)00221-4
10.1002/dvdy.24528
10.1093/gbe/evw264
10.7554/eLife.41548
10.1038/nprot.2016.080
10.1186/s13100-016-0059-7
10.1111/acel.12503
10.1016/j.gde.2017.04.006
10.1073/pnas.1804590115
10.1007/978-1-4939-0512-6_4
10.1016/S0022-2275(20)38452-2
10.1093/bioinformatics/btv145
10.1186/s13073-018-0539-0
10.1038/s41586-020-2453-z
10.1093/biolre/ioy112
10.1016/j.jlr.2021.100065
10.7554/eLife.59683
10.1101/gad.14.12.1512
10.1371/journal.pone.0029111
10.1371/journal.pbio.1000037
10.1093/oxfordjournals.molbev.a025819
10.1038/s41586-018-0734-6
10.1016/j.devcel.2021.02.024
10.1016/j.bbadis.2012.05.008
10.1098/rstb.2019.0347
10.1016/j.conb.2017.12.008
10.1101/pdb.prot107738
10.1111/mec.15982
10.1093/bib/bbs038
10.1038/nprot.2016.103
10.1021/cr2001355
10.1186/1471-2164-14-567
10.1038/nature13163
10.1038/s41556-023-01325-3
10.1038/s42003-019-0574-4
10.3390/cells9010109
10.1016/j.devcel.2018.06.003
10.1242/jeb.045906
10.1038/s41467-017-01982-7
10.1038/nrg.2016.139
10.1016/j.ceb.2008.02.005
10.1186/gb-2007-8-2-r24
10.1073/pnas.2018362118
10.1002/dvdy.24513
10.1002/dvdy.24594
10.1186/s13059-015-0721-2
10.1038/nature02549
10.3791/57073-v
10.1186/1471-213X-4-11
10.1016/j.devcel.2019.12.018
10.1093/bioinformatics/btw354
10.1073/pnas.2210404119
10.1038/nature12111
10.1038/s41586-019-1647-8
10.1093/bioinformatics/btt656
10.1038/nature10944
10.18632/aging.101887
10.1126/sciadv.abc9863
10.7554/eLife.43785
10.1093/bioinformatics/btp616
10.1073/pnas.1011803107
10.1038/366461a0
10.1016/j.cell.2019.06.004
10.1186/s13059-019-1832-y
10.1093/genetics/139.4.1567
10.1093/gigascience/giab008
10.1007/s00216-020-02640-6
10.1111/j.1601-5223.1968.tb02169.x
10.1038/nmeth.2019
10.1093/bioinformatics/btl567
10.1093/genetics/137.1.107
10.1093/molbev/msm088
10.1093/nar/gkz365
10.1016/S0022-2836(05)80360-2
10.1101/gr.1933104
10.1016/j.cell.2016.09.018
10.1101/pdb.prot107747
10.1186/s12944-019-1132-2
10.1126/science.aaz3090
10.1073/pnas.0802067105
10.1101/gr.6761107
10.1016/j.cbpa.2019.110591
10.1002/dvdy.24507
10.1146/annurev.genet.39.073003.114725
10.1126/science.aad8411
10.1016/j.bbalip.2015.12.010
10.1186/s13059-014-0550-8
10.1186/gb-2008-9-9-r137
10.1038/nbt.1754
10.1007/s12035-015-9658-4
10.1152/physiolgenomics.00072.2020
10.1038/nature10730
10.7554/eLife.65041
10.1038/nrg3481
10.1016/j.cell.2015.12.007
10.1186/1471-2105-12-124
10.1126/science.aaw2601
10.1016/j.molcel.2010.05.004
10.1016/j.cub.2018.06.031
10.1126/science.278.5341.1319
10.1111/1749-4877.12504
10.1016/j.plipres.2019.04.003
10.1101/gr.071407.107
10.1007/978-1-4939-6518-2_5
10.1111/brv.12183
10.1111/acel.12757
10.1126/science.1246426
10.1038/nrg2482
10.1016/j.celrep.2020.107949
10.1093/nar/gkt214
10.1016/j.cell.2015.10.071
10.1101/gr.215566.116
10.1371/journal.pbio.1000112
10.1093/bioinformatics/bts635
10.32614/RJ-2016-060
10.1093/nar/gkv318
10.1093/nar/gkw257
10.1242/jeb.202.19.2567
10.1016/j.cell.2015.01.006
10.1038/nmeth.3885
10.1016/S1534-5807(01)00085-5
10.7554/eLife.69058
10.1007/978-1-62703-646-7_10
10.1016/j.febslet.2010.03.046
10.1016/j.bone.2011.06.034
10.1023/A:1007598320759
10.1073/pnas.0409882102
10.1101/gr.133009.111
10.1038/nmeth.1923
10.1242/dev.148213
10.1007/s10522-018-9778-0
10.1113/jphysiol.2008.167692
10.1210/en.2003-0288
10.1016/j.plipres.2013.12.001
10.1016/j.celrep.2016.01.026
10.1038/nrg3521
10.1038/40194
10.1186/s12864-018-4539-7
10.1093/nar/gkp335
10.1038/s41598-018-35807-4
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Issue 13
Keywords metabolomics
diapause
suspended animation
epigenomics
killifish
aging
complex trait evolution
comparative genomics
epigenetics
lipidomics
Language English
License This is an open access article under the CC BY license.
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References Paul, Lancaster, Meikle (bib52) 2019; 74
Kuhn, Haussler, Kent (bib112) 2013; 14
Polačik, Blažek, Reichard (bib129) 2016; 11
Pedrelli, Parini, Kindberg, Arnemo, Bjorkhem, Aasa, Westerståhl, Walentinsson, Pavanello, Turri (bib91) 2021; 62
Blanchette, Kent, Riemer, Elnitski, Smit, Roskin, Baertsch, Rosenbloom, Clawson, Green (bib113) 2004; 14
Schindelin, Arganda-Carreras, Frise, Kaynig, Longair, Pietzsch, Preibisch, Rueden, Saalfeld, Schmid (bib140) 2012; 9
Cui, Tyers, Malubhoy, Wisotsky, Valdesalici, Henriette, Kosakovsky Pond, Valenzano (bib14) 2021; 30
Fenelon, Renfree (bib21) 2018; 99
Gao, Shen, Xue, Chen, Cui, Song (bib148) 2016; 7
Harmon, Lam, Glass (bib39) 2011; 111
Lechner, Findeiss, Steiner, Marz, Stadler, Prohaska (bib123) 2011; 12
Liu, Zimmerman, Patterson (bib36) 2004; 4
Podrabsky, Riggs, Romney, Woll, Wagner, Culpepper, Cleaver (bib132) 2017; 246
Dabrowski, Ripa, Latza, Annibal, Antebi (bib45) 2020; 412
Hussein, Wang, Mathieu, Margaretha, Song, Jones, Cavanaugh, Miklas, Mahen, Showalter (bib22) 2020; 52
Zhou, Dou, Fan, Zhang, Sanderford, Kaya, Johnson, Karlsson, Tian, Mikhalchenko (bib84) 2020; 32
Harel, Valenzano, Brunet (bib136) 2016; 11
Sim, Denlinger (bib37) 2008; 105
Ramírez, Ryan, Grüning, Bhardwaj, Kilpert, Richter, Heyne, Dündar, Manke (bib109) 2016; 44
Podrabsky, Garrett, Kohl (bib133) 2010; 213
Ross-Innes, Stark, Teschendorff, Holmes, Ali, Dunning, Brown, Gojis, Ellis, Green (bib146) 2012; 481
Church, Goodstadt, Hillier, Zody, Goldstein, She, Bult, Agarwala, Cherry, DiCuccio (bib97) 2009; 7
Romney, Davis, Corona, Wagner, Podrabsky (bib73) 2018; 115
Dobin, Davis, Schlesinger, Drenkow, Zaleski, Jha, Batut, Chaisson, Gingeras (bib105) 2013; 29
Yang (bib122) 2007; 24
Villar, Flicek, Odom (bib65) 2014; 15
Jansen, Trojahn, Saxton, Quackenbush, Evans Hutzenbiler, Nelson, Cornejo, Robbins, Kelley (bib82) 2019; 2
Larsen, Albert, Riddle (bib77) 1995; 139
Tejada-Martinez, de Magalhães, Opazo (bib63) 2021; 288
Olsen, Thum, Rohner (bib72) 2021; 56
Wu, Lam, Clay, Duong, Deo, Coughlin (bib53) 2018; 46
Emms, Kelly (bib100) 2015; 16
Smit, Hubley, Green (bib120) 2013–2015
Vazquez, Lynch (bib62) 2021; 10
Altschul, Gish, Miller, Myers, Lipman (bib101) 1990; 215
Liu, Robinson-Rechavi (bib28) 2020; 6
Gottlieb, Ruvkun (bib78) 1994; 137
Wang, Zhu, Sun, Yang, Chang, Xia, Lu, Xia, Yan, Bian, Gao (bib33) 2019; 18
Gerisch, Weitzel, Kober-Eisermann, Rottiers, Antebi (bib75) 2001; 1
Zečić, Braeckman (bib34) 2020; 9
Sela, Ashkenazy, Katoh, Pupko (bib125) 2015; 43
Miller, Rosenbloom, Hardison, Hou, Taylor, Raney, Burhans, King, Baertsch, Blankenberg (bib145) 2007; 17
Zhao, Zhu, Yu, Qiu, Zhang, He, Zhang (bib31) 2017; 54
Huang, Chen, Yang, Bai, Shi, Vistro, Tarique, Haseeb, Chen (bib88) 2019; 11
Andrew (bib103) 2010
van der Weijden, Stötzel, Iyer, Fauler, Gralinska, Shahraz, Meierhofer, Vingron, Rulands, Alexandrov (bib81) 2024; 26
Robinson, McCarthy, Smyth (bib117) 2010; 26
Lu, Aron, Zullo, Pan, Kim, Chen, Yang, Kim, Drake, Liu (bib30) 2014; 507
Sindelar, Guan, Dallner, Ernster (bib50) 1999; 26
Liao, Smyth, Shi (bib106) 2013; 41
Stark, Brown (bib116) 2011
Nakamura, Yudell, Loor (bib47) 2014; 53
Gupta, Stamatoyannopoulos, Bailey, Noble (bib147) 2007; 8
Hwangbo, Gershman, Tu, Palmer, Tatar (bib87) 2004; 429
Vella, Nelson, Jansen, Robbins, Jensen, Constantinescu, Abbott, Turcotte (bib94) 2020; 240
Salih, Brunet (bib35) 2008; 20
Jones, Grabherr, Chan, Russell, Mauceli, Johnson, Swofford, Pirun, Zody, White (bib64) 2012; 484
Cellerino, Valenzano, Reichard (bib1) 2016; 91
Ignatiadis, Klaus, Zaugg, Huber (bib151) 2016; 13
Ren, Song, Liu, Yang (bib92) 2022; 17
Conant, Wolfe (bib13) 2008; 9
Emms, Kelly (bib15) 2019; 20
Vierstra, Rynes, Sandstrom, Zhang, Canfield, Hansen, Stehling-Sun, Sabo, Byron, Humbert (bib66) 2014; 346
Reichwald, Petzold, Koch, Downie, Hartmann, Pietsch, Baumgart, Chalopin, Felder, Bens (bib8) 2015; 163
Kenyon, Chang, Gensch, Rudner, Tabtiang (bib76) 1993; 366
Reichard, Polačik (bib5) 2019; 8
Robinson, Thorvaldsdóttir, Winckler, Guttman, Lander, Getz, Mesirov (bib114) 2011; 29
Lan, Pritchard (bib16) 2016; 352
Braverman, Moser (bib51) 2012; 1822
Martin, Podrabsky (bib19) 2017; 246
Batz, Armbruster (bib95) 2018; 221
Jialin, V.R.R., Khoueiry, Reddington, Girardot, Furlong, Robinson-Rechavi (bib150) 2021
Guschanski, Warnefors, Kaessmann (bib58) 2017; 27
Pauli, Valen, Lin, Garber, Vastenhouw, Levin, Fan, Sandelin, Rinn, Regev, Schier (bib96) 2012; 22
Margulies, Vinson, Miller, Jaffe, Lindblad-Toh, Chang, Green, Lander, Mullikin, Clamp (bib144) 2005; 102
Sommer, Ståhlman, Ilkayeva, Arnemo, Kindberg, Josefsson, Newgard, Fröbert, Bäckhed (bib93) 2016; 14
Contrepois, Mahmoudi, Ubhi, Papsdorf, Hornburg, Brunet, Snyder (bib138) 2018; 8
Hwang, Zukin (bib41) 2018; 48
Wang, Hu, Zeng, Alegre, Hu, Gotting, Ortega Granillo, Wang, Robb, Schnittker (bib70) 2020; 369
Nelson, Otis, Carey (bib79) 2009; 587
Otis, Sahoo, Drover, Yen, Carey (bib90) 2011; 6
Furness, Reznick, Springer, Meredith (bib18) 2015; 282
Prestigio, Ferrante, Marte, Romei, Lignani, Onofri, Valente, Benfenati, Baldelli (bib42) 2021; 10
Wang (bib48) 2016; 1861
Kousteni (bib43) 2012; 50
Love, Huber, Anders (bib102) 2014; 15
Falcon, Gentleman (bib126) 2007; 23
Antebi, Yeh, Tait, Hedgecock, Riddle (bib74) 2000; 14
Nath, Bedbrook, Nagvekar, Brunet (bib131) 2023; 2023
Doganli, Sandoval, Thomas, Hart (bib135) 2017; 1507
Chen, Krinsky, Long (bib11) 2013; 14
Monteiro, Podlaha (bib57) 2009; 7
Lin, Dorman, Rodan, Kenyon (bib85) 1997; 278
Wagner, Singh, Romney, Riggs, Minx, Woll, Roush, Warren, Brunet, Podrabsky (bib9) 2018; 19
Koonin (bib10) 2005; 39
Zullo, Drake, Aron, O'Hern, Dhamne, Davidsohn, Mao, Klein, Rotenberg, Bennett (bib32) 2019; 574
Ogg, Paradis, Gottlieb, Patterson, Lee, Tissenbaum, Ruvkun (bib86) 1997; 389
Kroll, Powell, Ghosh, Gestri, Antinucci, Hearn, Tunbak, Lim, Dennis, Fernandez (bib54) 2021; 10
Platzer, Englert (bib2) 2016; 32
Harris (bib111) 2007
Labun, Montague, Krause, Torres Cleuren, Tjeldnes, Valen (bib127) 2019; 47
Löytynoja (bib124) 2014; 1079
Renfree, Fenelon (bib7) 2017; 144
Zhang, Wang, Li, Xu (bib38) 2022; 119
Xu, Shao, Fedorov, Goropashnaya, Barnes, Yan (bib83) 2013; 14
Sotero-Caio, Platt, Suh, Ray (bib149) 2017; 9
Podrabsky, Arezo (bib20) 2017; 246
Chuong, Elde, Feschotte (bib26) 2017; 18
Zhang, Liu, Meyer, Eeckhoute, Johnson, Bernstein, Nusbaum, Myers, Brown, Li, Liu (bib110) 2008; 9
Long, Prescott, Wysocka (bib55) 2016; 167
Tang, Masaaki (bib115) 2016; 8/2
Elle, Olsen, Pultz, Rødkaer, Faergeman (bib49) 2010; 584
Howe, Clark, Torroja, Torrance, Berthelot, Muffato, Collins, Humphray, McLaren, Matthews (bib99) 2013; 496
Blokzijl, Janssen, van Boxtel, Cuppen (bib121) 2018; 10
Reeves, Singh, Brunet (bib137) 2024; 2024
Liao, Smyth, Shi (bib142) 2014; 30
Yu, Wang, He (bib118) 2015; 31
Yang, Stevens, Chen, Lee, Stähli, Gate, Contrepois, Chen, Iram, Zhang (bib139) 2020; 583
Dodzian, Kean, Seidel, Valenzano (bib130) 2018
Buenrostro, Giresi, Zaba, Chang, Greenleaf (bib23) 2013; 10
Zajic, Podrabsky (bib46) 2020; 52
Ichikawa, Tomioka, Suzuki, Nakamura, Doi, Yoshimura, Kumagai, Inoue, Uchida, Irie (bib98) 2017; 8
Podrabsky (bib128) 1999; 54
Heinz, Benner, Spann, Bertolino, Lin, Laslo, Cheng, Murre, Singh, Glass (bib27) 2010; 38
Indjeian, Kingman, Jones, Guenther, Grimwood, Schmutz, Myers, Kingsley (bib67) 2016; 164
Danecek, Bonfield, Liddle, Marshall, Ohan, Pollard, Whitwham, Keane, McCarthy, Davies, Li (bib108) 2021; 10
Hu, Wang, Brind'Amour, Singh, Reeves, Lorincz, Alvarado, Brunet (bib6) 2020; 367
Wu, Hu, Xu, Chen, Guo, Dai, Feng, Zhou, Tang, Zhan (bib152) 2021; 2
Ewels, Magnusson, Lundin, Käller (bib104) 2016; 32
Arnegard, Zwickl, Lu, Zakon (bib59) 2010; 107
Vrtílek, Žák, Pšenička, Reichard (bib3) 2018; 28
Podrabsky, Hand (bib134) 1999; 202
Arena, Bisogno, Gąsior, Rudnicka, Bernhardt, Haaf, Zacchini, Bochenek, Fic, Bik (bib80) 2021; 118
Rebeiz, Tsiantis (bib25) 2017; 45
Lee, Olson, Evans (bib40) 2003; 144
Villar, Berthelot, Aldridge, Rayner, Lukk, Pignatelli, Park, Deaville, Erichsen, Jasinska (bib56) 2015; 160
Knox, Baker (bib60) 2008; 18
Vrtílek, Polačik, Reichard (bib71) 2017; 246
Bailey, Boden, Buske, Frith, Grant, Clementi, Ren, Li, Noble (bib119) 2009; 37
Sundaram, Wysocka (bib69) 2020; 375
Laplaud, Beaubatie, Rall, Luc, Saboureau (bib89) 1988; 29
Marlétaz, Firbas, Maeso, Tena, Bogdanovic, Perry, Wyatt, de la Calle-Mustienes, Bertrand, Burguera (bib24) 2018; 564
Almaida-Pagan, Ortega-Sabater, Lucas-Sanchez, Gonzalez-Silvera, Martinez-Nicolas, Rol de Lama, Mendiola, de Costa (bib44) 2019; 20
Hu, Brunet (bib4) 2018; 17
Murphy, Collier (bib17) 1997; 14
Yates, Achuthan, Akanni, Allen, Allen, Alvarez-Jarreta, Amode, Armean, Azov, Bennett (bib141) 2020; 48
Cui, Medeiros, Willemsen, Iasi, Collier, Graef, Reichard, Valenzano (bib29) 2019; 178
Ohno, Wolf, Atkin (bib12) 1968; 59
Verta, Jones (bib68) 2019; 8
Langmead, Salzberg (bib107) 2012; 9
Liu (bib143) 2014; 1150
Doherty, de Magalhães (bib61) 2016; 15
Cellerino (10.1016/j.cell.2024.04.048_bib1) 2016; 91
Elle (10.1016/j.cell.2024.04.048_bib49) 2010; 584
Renfree (10.1016/j.cell.2024.04.048_bib7) 2017; 144
Romney (10.1016/j.cell.2024.04.048_bib73) 2018; 115
Hussein (10.1016/j.cell.2024.04.048_bib22) 2020; 52
Ramírez (10.1016/j.cell.2024.04.048_bib109) 2016; 44
Schindelin (10.1016/j.cell.2024.04.048_bib140) 2012; 9
Wang (10.1016/j.cell.2024.04.048_bib33) 2019; 18
Vierstra (10.1016/j.cell.2024.04.048_bib66) 2014; 346
Ewels (10.1016/j.cell.2024.04.048_bib104) 2016; 32
Hwang (10.1016/j.cell.2024.04.048_bib41) 2018; 48
Liao (10.1016/j.cell.2024.04.048_bib106) 2013; 41
Olsen (10.1016/j.cell.2024.04.048_bib72) 2021; 56
Jones (10.1016/j.cell.2024.04.048_bib64) 2012; 484
Stark (10.1016/j.cell.2024.04.048_bib116) 2011
Ross-Innes (10.1016/j.cell.2024.04.048_bib146) 2012; 481
Kenyon (10.1016/j.cell.2024.04.048_bib76) 1993; 366
Rebeiz (10.1016/j.cell.2024.04.048_bib25) 2017; 45
van der Weijden (10.1016/j.cell.2024.04.048_bib81) 2024; 26
Blokzijl (10.1016/j.cell.2024.04.048_bib121) 2018; 10
Wang (10.1016/j.cell.2024.04.048_bib70) 2020; 369
Long (10.1016/j.cell.2024.04.048_bib55) 2016; 167
Löytynoja (10.1016/j.cell.2024.04.048_bib124) 2014; 1079
Sommer (10.1016/j.cell.2024.04.048_bib93) 2016; 14
Zajic (10.1016/j.cell.2024.04.048_bib46) 2020; 52
Vella (10.1016/j.cell.2024.04.048_bib94) 2020; 240
Yang (10.1016/j.cell.2024.04.048_bib139) 2020; 583
Koonin (10.1016/j.cell.2024.04.048_bib10) 2005; 39
Yang (10.1016/j.cell.2024.04.048_bib122) 2007; 24
Nath (10.1016/j.cell.2024.04.048_bib131) 2023; 2023
Podrabsky (10.1016/j.cell.2024.04.048_bib134) 1999; 202
Antebi (10.1016/j.cell.2024.04.048_bib74) 2000; 14
Indjeian (10.1016/j.cell.2024.04.048_bib67) 2016; 164
Nelson (10.1016/j.cell.2024.04.048_bib79) 2009; 587
Reichwald (10.1016/j.cell.2024.04.048_bib8) 2015; 163
Marlétaz (10.1016/j.cell.2024.04.048_bib24) 2018; 564
Paul (10.1016/j.cell.2024.04.048_bib52) 2019; 74
Hu (10.1016/j.cell.2024.04.048_bib6) 2020; 367
Yu (10.1016/j.cell.2024.04.048_bib118) 2015; 31
Emms (10.1016/j.cell.2024.04.048_bib15) 2019; 20
Robinson (10.1016/j.cell.2024.04.048_bib114) 2011; 29
Guschanski (10.1016/j.cell.2024.04.048_bib58) 2017; 27
Wang (10.1016/j.cell.2024.04.048_bib48) 2016; 1861
Hwangbo (10.1016/j.cell.2024.04.048_bib87) 2004; 429
Reeves (10.1016/j.cell.2024.04.048_bib137) 2024; 2024
Lan (10.1016/j.cell.2024.04.048_bib16) 2016; 352
Ren (10.1016/j.cell.2024.04.048_bib92) 2022; 17
Ogg (10.1016/j.cell.2024.04.048_bib86) 1997; 389
Harel (10.1016/j.cell.2024.04.048_bib136) 2016; 11
Polačik (10.1016/j.cell.2024.04.048_bib129) 2016; 11
Platzer (10.1016/j.cell.2024.04.048_bib2) 2016; 32
Pedrelli (10.1016/j.cell.2024.04.048_bib91) 2021; 62
Howe (10.1016/j.cell.2024.04.048_bib99) 2013; 496
Podrabsky (10.1016/j.cell.2024.04.048_bib128) 1999; 54
Hu (10.1016/j.cell.2024.04.048_bib4) 2018; 17
Prestigio (10.1016/j.cell.2024.04.048_bib42) 2021; 10
Labun (10.1016/j.cell.2024.04.048_bib127) 2019; 47
Zhang (10.1016/j.cell.2024.04.048_bib110) 2008; 9
Blanchette (10.1016/j.cell.2024.04.048_bib113) 2004; 14
Liu (10.1016/j.cell.2024.04.048_bib36) 2004; 4
Falcon (10.1016/j.cell.2024.04.048_bib126) 2007; 23
Villar (10.1016/j.cell.2024.04.048_bib56) 2015; 160
Wu (10.1016/j.cell.2024.04.048_bib152) 2021; 2
Liao (10.1016/j.cell.2024.04.048_bib142) 2014; 30
Bailey (10.1016/j.cell.2024.04.048_bib119) 2009; 37
Danecek (10.1016/j.cell.2024.04.048_bib108) 2021; 10
Tejada-Martinez (10.1016/j.cell.2024.04.048_bib63) 2021; 288
Liu (10.1016/j.cell.2024.04.048_bib143) 2014; 1150
Vazquez (10.1016/j.cell.2024.04.048_bib62) 2021; 10
Cui (10.1016/j.cell.2024.04.048_bib29) 2019; 178
Love (10.1016/j.cell.2024.04.048_bib102) 2014; 15
Batz (10.1016/j.cell.2024.04.048_bib95) 2018; 221
Wagner (10.1016/j.cell.2024.04.048_bib9) 2018; 19
Podrabsky (10.1016/j.cell.2024.04.048_bib20) 2017; 246
Buenrostro (10.1016/j.cell.2024.04.048_bib23) 2013; 10
Sindelar (10.1016/j.cell.2024.04.048_bib50) 1999; 26
Jansen (10.1016/j.cell.2024.04.048_bib82) 2019; 2
Zhou (10.1016/j.cell.2024.04.048_bib84) 2020; 32
Arena (10.1016/j.cell.2024.04.048_bib80) 2021; 118
Miller (10.1016/j.cell.2024.04.048_bib145) 2007; 17
Verta (10.1016/j.cell.2024.04.048_bib68) 2019; 8
Harmon (10.1016/j.cell.2024.04.048_bib39) 2011; 111
Fenelon (10.1016/j.cell.2024.04.048_bib21) 2018; 99
Chuong (10.1016/j.cell.2024.04.048_bib26) 2017; 18
Gupta (10.1016/j.cell.2024.04.048_bib147) 2007; 8
Smit (10.1016/j.cell.2024.04.048_bib120) 2013
Doganli (10.1016/j.cell.2024.04.048_bib135) 2017; 1507
Lu (10.1016/j.cell.2024.04.048_bib30) 2014; 507
Lee (10.1016/j.cell.2024.04.048_bib40) 2003; 144
Almaida-Pagan (10.1016/j.cell.2024.04.048_bib44) 2019; 20
Kroll (10.1016/j.cell.2024.04.048_bib54) 2021; 10
Margulies (10.1016/j.cell.2024.04.048_bib144) 2005; 102
Vrtílek (10.1016/j.cell.2024.04.048_bib71) 2017; 246
Vrtílek (10.1016/j.cell.2024.04.048_bib3) 2018; 28
Sim (10.1016/j.cell.2024.04.048_bib37) 2008; 105
Ignatiadis (10.1016/j.cell.2024.04.048_bib151) 2016; 13
Salih (10.1016/j.cell.2024.04.048_bib35) 2008; 20
Dodzian (10.1016/j.cell.2024.04.048_bib130) 2018
Huang (10.1016/j.cell.2024.04.048_bib88) 2019; 11
Podrabsky (10.1016/j.cell.2024.04.048_bib132) 2017; 246
Gao (10.1016/j.cell.2024.04.048_bib148) 2016; 7
Emms (10.1016/j.cell.2024.04.048_bib100) 2015; 16
Heinz (10.1016/j.cell.2024.04.048_bib27) 2010; 38
Furness (10.1016/j.cell.2024.04.048_bib18) 2015; 282
Xu (10.1016/j.cell.2024.04.048_bib83) 2013; 14
Braverman (10.1016/j.cell.2024.04.048_bib51) 2012; 1822
Doherty (10.1016/j.cell.2024.04.048_bib61) 2016; 15
Ohno (10.1016/j.cell.2024.04.048_bib12) 1968; 59
Liu (10.1016/j.cell.2024.04.048_bib28) 2020; 6
Dabrowski (10.1016/j.cell.2024.04.048_bib45) 2020; 412
Lin (10.1016/j.cell.2024.04.048_bib85) 1997; 278
Zečić (10.1016/j.cell.2024.04.048_bib34) 2020; 9
Larsen (10.1016/j.cell.2024.04.048_bib77) 1995; 139
Langmead (10.1016/j.cell.2024.04.048_bib107) 2012; 9
Wu (10.1016/j.cell.2024.04.048_bib53) 2018; 46
Podrabsky (10.1016/j.cell.2024.04.048_bib133) 2010; 213
Murphy (10.1016/j.cell.2024.04.048_bib17) 1997; 14
Jialin (10.1016/j.cell.2024.04.048_bib150) 2021
Pauli (10.1016/j.cell.2024.04.048_bib96) 2012; 22
Kousteni (10.1016/j.cell.2024.04.048_bib43) 2012; 50
Cui (10.1016/j.cell.2024.04.048_bib14) 2021; 30
Nakamura (10.1016/j.cell.2024.04.048_bib47) 2014; 53
Harris (10.1016/j.cell.2024.04.048_bib111) 2007
Monteiro (10.1016/j.cell.2024.04.048_bib57) 2009; 7
Knox (10.1016/j.cell.2024.04.048_bib60) 2008; 18
Reichard (10.1016/j.cell.2024.04.048_bib5) 2019; 8
Yates (10.1016/j.cell.2024.04.048_bib141) 2020; 48
Sotero-Caio (10.1016/j.cell.2024.04.048_bib149) 2017; 9
Chen (10.1016/j.cell.2024.04.048_bib11) 2013; 14
Villar (10.1016/j.cell.2024.04.048_bib65) 2014; 15
Conant (10.1016/j.cell.2024.04.048_bib13) 2008; 9
Robinson (10.1016/j.cell.2024.04.048_bib117) 2010; 26
Tang (10.1016/j.cell.2024.04.048_bib115) 2016; 8/2
Dobin (10.1016/j.cell.2024.04.048_bib105) 2013; 29
Contrepois (10.1016/j.cell.2024.04.048_bib138) 2018; 8
Gerisch (10.1016/j.cell.2024.04.048_bib75) 2001; 1
Lechner (10.1016/j.cell.2024.04.048_bib123) 2011; 12
Laplaud (10.1016/j.cell.2024.04.048_bib89) 1988; 29
Altschul (10.1016/j.cell.2024.04.048_bib101) 1990; 215
Zullo (10.1016/j.cell.2024.04.048_bib32) 2019; 574
Church (10.1016/j.cell.2024.04.048_bib97) 2009; 7
Ichikawa (10.1016/j.cell.2024.04.048_bib98) 2017; 8
Martin (10.1016/j.cell.2024.04.048_bib19) 2017; 246
Arnegard (10.1016/j.cell.2024.04.048_bib59) 2010; 107
Gottlieb (10.1016/j.cell.2024.04.048_bib78) 1994; 137
Sela (10.1016/j.cell.2024.04.048_bib125) 2015; 43
Zhang (10.1016/j.cell.2024.04.048_bib38) 2022; 119
Otis (10.1016/j.cell.2024.04.048_bib90) 2011; 6
Sundaram (10.1016/j.cell.2024.04.048_bib69) 2020; 375
Andrew (10.1016/j.cell.2024.04.048_bib103) 2010
Zhao (10.1016/j.cell.2024.04.048_bib31) 2017; 54
Kuhn (10.1016/j.cell.2024.04.048_bib112) 2013; 14
References_xml – volume: 32
  start-page: 543
  year: 2016
  end-page: 552
  ident: bib2
  article-title: Nothobranchius furzeri: A Model for Aging Research and More
  publication-title: Trends Genet.
– volume: 7
  year: 2009
  ident: bib97
  article-title: Lineage-specific biology revealed by a finished genome assembly of the mouse
  publication-title: PLoS Biol.
– year: 2011
  ident: bib116
  article-title: DiffBind: differential binding analysis of ChIP-Seq peak data
– volume: 1507
  start-page: 59
  year: 2017
  end-page: 66
  ident: bib135
  article-title: Assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-Seq) protocol for zebrafish embryos
  publication-title: Methods Mol. Biol.
– volume: 11
  start-page: 2010
  year: 2016
  end-page: 2028
  ident: bib136
  article-title: Efficient genome engineering approaches for the short-lived African turquoise killifish
  publication-title: Nat. Protoc.
– volume: 18
  start-page: 695
  year: 2008
  end-page: 705
  ident: bib60
  article-title: Genomic evolution of the placenta using co-option and duplication and divergence
  publication-title: Genome Res.
– volume: 8
  year: 2018
  ident: bib138
  article-title: Cross-platform comparison of untargeted and targeted lipidomics approaches on aging mouse plasma
  publication-title: Sci. Rep.
– volume: 28
  start-page: R822
  year: 2018
  end-page: R824
  ident: bib3
  article-title: Extremely rapid maturation of a wild African annual fish
  publication-title: Curr. Biol.
– volume: 39
  start-page: 309
  year: 2005
  end-page: 338
  ident: bib10
  article-title: Orthologs, paralogs, and evolutionary genomics
  publication-title: Annu. Rev. Genet.
– volume: 144
  start-page: 2201
  year: 2003
  end-page: 2207
  ident: bib40
  article-title: Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
  publication-title: Endocrinology
– volume: 43
  start-page: W7
  year: 2015
  end-page: W14
  ident: bib125
  article-title: GUIDANCE2: accurate detection of unreliable alignment regions accounting for the uncertainty of multiple parameters
  publication-title: Nucleic Acids Res.
– volume: 9
  start-page: 161
  year: 2017
  end-page: 177
  ident: bib149
  article-title: Evolution and diversity of transposable elements in vertebrate genomes
  publication-title: Genome Biol. Evol.
– volume: 481
  start-page: 389
  year: 2012
  end-page: 393
  ident: bib146
  article-title: Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
  publication-title: Nature
– volume: 48
  start-page: D682
  year: 2020
  end-page: D688
  ident: bib141
  article-title: Ensembl 2020
  publication-title: Nucleic Acids Res.
– volume: 29
  start-page: 15
  year: 2013
  end-page: 21
  ident: bib105
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
– volume: 52
  start-page: 236
  year: 2020
  end-page: 250.e7
  ident: bib22
  article-title: Metabolic control over mTOR-dependent diapause-like state
  publication-title: Dev. Cell
– volume: 587
  start-page: 1863
  year: 2009
  end-page: 1870
  ident: bib79
  article-title: A role for nuclear receptors in mammalian hibernation
  publication-title: J. Physiol.
– volume: 54
  start-page: 541
  year: 2017
  end-page: 550
  ident: bib31
  article-title: Brain REST/NRSF is not only a silent repressor but also an active protector
  publication-title: Mol. Neurobiol.
– volume: 246
  year: 2017
  ident: bib20
  article-title: Annual killifishes as model systems for advancing understanding of evolution and developmental biology
  publication-title: Dev. Dyn.
– year: 2018
  ident: bib130
  article-title: A Protocol for Laboratory Housing of Turquoise killifish (Nothobranchius furzeri)
  publication-title: J. Vis. Exp.
– volume: 564
  start-page: 64
  year: 2018
  end-page: 70
  ident: bib24
  article-title: Amphioxus functional genomics and the origins of vertebrate gene regulation
  publication-title: Nature
– volume: 46
  start-page: 112
  year: 2018
  end-page: 125.e4
  ident: bib53
  article-title: A rapid method for directed gene knockout for screening in G0 zebrafish
  publication-title: Dev. Cell
– volume: 507
  start-page: 448
  year: 2014
  end-page: 454
  ident: bib30
  article-title: REST and stress resistance in ageing and Alzheimer's disease
  publication-title: Nature
– volume: 139
  start-page: 1567
  year: 1995
  end-page: 1583
  ident: bib77
  article-title: Genes that regulate both development and longevity in Caenorhabditis elegans
  publication-title: Genetics
– volume: 13
  start-page: 577
  year: 2016
  end-page: 580
  ident: bib151
  article-title: Data-driven hypothesis weighting increases detection power in genome-scale multiple testing
  publication-title: Nat. Methods
– volume: 221
  year: 2018
  ident: bib95
  article-title: Diapause-associated changes in the lipid and metabolite profiles of the Asian tiger mosquito, Aedes albopictus
  publication-title: J. Exp. Biol.
– volume: 213
  start-page: 3280
  year: 2010
  end-page: 3288
  ident: bib133
  article-title: Alternative developmental pathways associated with diapause regulated by temperature and maternal influences in embryos of the annual killifish Austrofundulus limnaeus
  publication-title: J. Exp. Biol.
– volume: 367
  start-page: 870
  year: 2020
  end-page: 874
  ident: bib6
  article-title: Vertebrate diapause preserves organisms long term through Polycomb complex members
  publication-title: Science
– volume: 45
  start-page: 115
  year: 2017
  end-page: 123
  ident: bib25
  article-title: Enhancer evolution and the origins of morphological novelty
  publication-title: Curr. Opin. Genet. Dev.
– volume: 2024
  year: 2024
  ident: bib137
  article-title: Chromatin Accessibility Profiling and Data Analysis Using ATAC-seq in Nothobranchius furzeri
  publication-title: Cold Spring Harb. Protoc.
– volume: 37
  start-page: W202
  year: 2009
  end-page: W208
  ident: bib119
  article-title: MEME SUITE: tools for motif discovery and searching
  publication-title: Nucleic Acids Res.
– volume: 24
  start-page: 1586
  year: 2007
  end-page: 1591
  ident: bib122
  article-title: PAML 4: phylogenetic analysis by maximum likelihood
  publication-title: Mol. Biol. Evol.
– volume: 107
  start-page: 22172
  year: 2010
  end-page: 22177
  ident: bib59
  article-title: Old gene duplication facilitates origin and diversification of an innovative communication system--twice
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 14
  start-page: 1655
  year: 2016
  end-page: 1661
  ident: bib93
  article-title: The gut microbiota modulates energy metabolism in the hibernating brown bear Ursus arctos
  publication-title: Cell Rep.
– volume: 160
  start-page: 554
  year: 2015
  end-page: 566
  ident: bib56
  article-title: Enhancer evolution across 20 mammalian species
  publication-title: Cell
– volume: 375
  year: 2020
  ident: bib69
  article-title: Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
– volume: 8
  year: 2017
  ident: bib98
  article-title: Centromere evolution and CpG methylation during vertebrate speciation
  publication-title: Nat. Commun.
– volume: 30
  start-page: 3610
  year: 2021
  end-page: 3623
  ident: bib14
  article-title: Ancestral transoceanic colonization and recent population reduction in a nonannual killifish from the Seychelles archipelago
  publication-title: Mol. Ecol.
– volume: 7
  year: 2016
  ident: bib148
  article-title: The contribution of transposable elements to size variations between four teleost genomes
  publication-title: Mobile DNA
– volume: 389
  start-page: 994
  year: 1997
  end-page: 999
  ident: bib86
  article-title: The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
  publication-title: Nature
– volume: 27
  start-page: 1461
  year: 2017
  end-page: 1474
  ident: bib58
  article-title: The evolution of duplicate gene expression in mammalian organs
  publication-title: Genome Res.
– volume: 16
  year: 2015
  ident: bib100
  article-title: OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy
  publication-title: Genome Biol.
– volume: 48
  start-page: 193
  year: 2018
  end-page: 200
  ident: bib41
  article-title: REST, a master transcriptional regulator in neurodegenerative disease
  publication-title: Curr. Opin. Neurobiol.
– volume: 23
  start-page: 257
  year: 2007
  end-page: 258
  ident: bib126
  article-title: Using GOstats to test gene lists for GO term association
  publication-title: Bioinformatics
– volume: 14
  start-page: 1512
  year: 2000
  end-page: 1527
  ident: bib74
  article-title: daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans
  publication-title: Genes Dev.
– volume: 62
  year: 2021
  ident: bib91
  article-title: Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos)
  publication-title: J. Lipid Res.
– volume: 74
  start-page: 186
  year: 2019
  end-page: 195
  ident: bib52
  article-title: Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease
  publication-title: Prog. Lipid Res.
– volume: 41
  year: 2013
  ident: bib106
  article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
  publication-title: Nucleic Acids Res.
– volume: 31
  start-page: 2382
  year: 2015
  end-page: 2383
  ident: bib118
  article-title: ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
  publication-title: Bioinformatics
– year: 2010
  ident: bib103
  article-title: FastQC: a Quality Control Tool for High Throughput Sequence Data
– volume: 29
  start-page: 1157
  year: 1988
  end-page: 1170
  ident: bib89
  article-title: Lipoprotein[a] is the major apoB-containing lipoprotein in the plasma of a hibernator, the hedgehog (Erinaceus europaeus)
  publication-title: J. Lipid Res.
– volume: 288
  year: 2021
  ident: bib63
  article-title: Positive selection and gene duplications in tumour suppressor genes reveal clues about how cetaceans resist cancer
  publication-title: Proc. Biol. Sci.
– volume: 8
  year: 2019
  ident: bib5
  article-title: Nothobranchius furzeri, an 'instant' fish from an ephemeral habitat
  publication-title: eLife
– volume: 14
  year: 2013
  ident: bib83
  article-title: Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes
  publication-title: BMC Genomics
– volume: 178
  start-page: 385
  year: 2019
  end-page: 399.e20
  ident: bib29
  article-title: Relaxed selection limits lifespan by increasing mutation load
  publication-title: Cell
– volume: 119
  year: 2022
  ident: bib38
  article-title: FoxO induces pupal diapause by decreasing TGFbeta signaling
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 20
  start-page: 83
  year: 2019
  end-page: 92
  ident: bib44
  article-title: Age-related changes in mitochondrial membrane composition of Nothobranchius furzeri.: comparison with a longer-living Nothobranchius species
  publication-title: Biogerontology
– volume: 20
  start-page: 126
  year: 2008
  end-page: 136
  ident: bib35
  article-title: FoxO transcription factors in the maintenance of cellular homeostasis during aging
  publication-title: Curr. Opin. Cell Biol.
– volume: 167
  start-page: 1170
  year: 2016
  end-page: 1187
  ident: bib55
  article-title: Ever-changing landscapes: transcriptional enhancers in development and evolution
  publication-title: Cell
– volume: 12
  year: 2011
  ident: bib123
  article-title: Proteinortho: detection of (co-)orthologs in large-scale analysis
  publication-title: BMC Bioinformatics
– volume: 50
  start-page: 437
  year: 2012
  end-page: 443
  ident: bib43
  article-title: FoxO1, the transcriptional chief of staff of energy metabolism
  publication-title: Bone
– volume: 111
  start-page: 6321
  year: 2011
  end-page: 6340
  ident: bib39
  article-title: PPARs and lipid ligands in inflammation and metabolism
  publication-title: Chem. Rev.
– volume: 215
  start-page: 403
  year: 1990
  end-page: 410
  ident: bib101
  article-title: Basic local alignment search tool
  publication-title: J. Mol. Biol.
– volume: 1861
  start-page: 793
  year: 2016
  end-page: 805
  ident: bib48
  article-title: Lipid droplets, lipophagy, and beyond
  publication-title: Biochim. Biophys. Acta
– volume: 32
  year: 2020
  ident: bib84
  article-title: Beaver and naked mole rat genomes reveal common paths to longevity
  publication-title: Cell Rep.
– volume: 17
  start-page: 297
  year: 2022
  end-page: 310
  ident: bib92
  article-title: Phenotypic changes in the metabolic profile and adiponectin activity during seasonal fattening and hibernation in female Daurian ground squirrels (Spermophilus dauricus)
  publication-title: Integr. Zool.
– volume: 32
  start-page: 3047
  year: 2016
  end-page: 3048
  ident: bib104
  article-title: MultiQC: summarize analysis results for multiple tools and samples in a single report
  publication-title: Bioinformatics
– volume: 91
  start-page: 511
  year: 2016
  end-page: 533
  ident: bib1
  article-title: From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology
  publication-title: Biol. Rev. Camb. Philos. Soc.
– volume: 20
  year: 2019
  ident: bib15
  article-title: OrthoFinder: phylogenetic orthology inference for comparative genomics
  publication-title: Genome Biol.
– volume: 99
  start-page: 242
  year: 2018
  end-page: 251
  ident: bib21
  article-title: The history of the discovery of embryonic diapause in mammals
  publication-title: Biol. Reprod.
– volume: 10
  year: 2021
  ident: bib42
  article-title: REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion
  publication-title: eLife
– volume: 2023
  year: 2023
  ident: bib131
  article-title: Husbandry of the African Turquoise killifish Nothobranchius furzeri
  publication-title: Cold Spring Harb. Protoc.
– volume: 246
  start-page: 838
  year: 2017
  end-page: 847
  ident: bib71
  article-title: The role of energetic reserves during embryonic development of an annual killifish
  publication-title: Dev. Dyn.
– volume: 246
  start-page: 779
  year: 2017
  end-page: 801
  ident: bib132
  article-title: Embryonic development of the annual killifish Austrofundulus limnaeus: an emerging model for ecological and evolutionary developmental biology research and instruction
  publication-title: Dev. Dyn.
– volume: 14
  start-page: 790
  year: 1997
  end-page: 799
  ident: bib17
  article-title: A molecular phylogeny for aplocheiloid fishes (Atherinomorpha, Cyprinodontiformes): the role of vicariance and the origins of annualism
  publication-title: Mol. Biol. Evol.
– volume: 10
  year: 2018
  ident: bib121
  article-title: MutationalPatterns: comprehensive genome-wide analysis of mutational processes
  publication-title: Genome Med.
– volume: 17
  start-page: 1797
  year: 2007
  end-page: 1808
  ident: bib145
  article-title: 28-way vertebrate alignment and conservation track in the UCSC Genome Browser
  publication-title: Genome Res.
– volume: 44
  start-page: W160
  year: 2016
  end-page: W165
  ident: bib109
  article-title: deepTools2: a next generation web server for deep-sequencing data analysis
  publication-title: Nucleic Acids Res.
– volume: 7
  year: 2009
  ident: bib57
  article-title: Wings, horns, and butterfly eyespots: how do complex traits evolve?
  publication-title: PLoS Biol.
– volume: 6
  year: 2011
  ident: bib90
  article-title: Cholesterol and lipoprotein dynamics in a hibernating mammal
  publication-title: PLoS One
– volume: 22
  start-page: 577
  year: 2012
  end-page: 591
  ident: bib96
  article-title: Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis
  publication-title: Genome Res.
– volume: 1079
  start-page: 155
  year: 2014
  end-page: 170
  ident: bib124
  article-title: Phylogeny-aware alignment with PRANK
  publication-title: Methods Mol. Biol.
– volume: 53
  start-page: 124
  year: 2014
  end-page: 144
  ident: bib47
  article-title: Regulation of energy metabolism by long-chain fatty acids
  publication-title: Prog. Lipid Res.
– volume: 15
  start-page: 221
  year: 2014
  end-page: 233
  ident: bib65
  article-title: Evolution of transcription factor binding in metazoans - mechanisms and functional implications
  publication-title: Nat. Rev. Genet.
– volume: 202
  start-page: 2567
  year: 1999
  end-page: 2580
  ident: bib134
  article-title: The bioenergetics of embryonic diapause in an annual killifish, austrofundulus limnaeus
  publication-title: J. Exp. Biol.
– year: 2021
  ident: bib150
  article-title: The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection
  publication-title: bioRxiv
– volume: 10
  year: 2021
  ident: bib54
  article-title: A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes
  publication-title: eLife
– volume: 584
  start-page: 2183
  year: 2010
  end-page: 2193
  ident: bib49
  article-title: Something worth dyeing for: molecular tools for the dissection of lipid metabolism in Caenorhabditis elegans
  publication-title: FEBS Lett.
– volume: 1822
  start-page: 1442
  year: 2012
  end-page: 1452
  ident: bib51
  article-title: Functions of plasmalogen lipids in health and disease
  publication-title: Biochim. Biophys. Acta
– volume: 240
  year: 2020
  ident: bib94
  article-title: Regulation of metabolism during hibernation in brown bears (Ursus arctos): involvement of cortisol, PGC-1alpha and AMPK in adipose tissue and skeletal muscle
  publication-title: Comp. Biochem. Physiol. A Mol. Integr. Physiol.
– volume: 9
  start-page: 938
  year: 2008
  end-page: 950
  ident: bib13
  article-title: Turning a hobby into a job: how duplicated genes find new functions
  publication-title: Nat. Rev. Genet.
– volume: 144
  start-page: 3199
  year: 2017
  end-page: 3210
  ident: bib7
  article-title: The enigma of embryonic diapause
  publication-title: Development
– volume: 9
  start-page: 357
  year: 2012
  end-page: 359
  ident: bib107
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
– volume: 366
  start-page: 461
  year: 1993
  end-page: 464
  ident: bib76
  article-title: A C. elegans mutant that lives twice as long as wild type
  publication-title: Nature
– volume: 6
  year: 2020
  ident: bib28
  article-title: Robust inference of positive selection on regulatory sequences in the human brain
  publication-title: Sci. Adv.
– volume: 15
  year: 2014
  ident: bib102
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
– volume: 8
  year: 2019
  ident: bib68
  article-title: Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks
  publication-title: eLife
– volume: 29
  start-page: 24
  year: 2011
  end-page: 26
  ident: bib114
  article-title: Integrative genomics viewer
  publication-title: Nat. Biotechnol.
– volume: 47
  start-page: W171
  year: 2019
  end-page: W174
  ident: bib127
  article-title: CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing
  publication-title: Nucleic Acids Res.
– volume: 1150
  start-page: 81
  year: 2014
  end-page: 95
  ident: bib143
  article-title: Use model-based analysis of ChIP-Seq (MACS) to analyze short reads generated by sequencing protein-DNA interactions in embryonic stem cells
  publication-title: Methods Mol. Biol.
– volume: 19
  year: 2018
  ident: bib9
  article-title: The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development
  publication-title: BMC Genomics
– volume: 17
  year: 2018
  ident: bib4
  article-title: The African turquoise killifish: A research organism to study vertebrate aging and diapause
  publication-title: Aging Cell
– volume: 2
  year: 2019
  ident: bib82
  article-title: Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear
  publication-title: Commun. Biol.
– volume: 484
  start-page: 55
  year: 2012
  end-page: 61
  ident: bib64
  article-title: The genomic basis of adaptive evolution in threespine sticklebacks
  publication-title: Nature
– volume: 26
  start-page: 318
  year: 1999
  end-page: 324
  ident: bib50
  article-title: The protective role of plasmalogens in iron-induced lipid peroxidation
  publication-title: Free Radic. Biol. Med.
– volume: 14
  start-page: 645
  year: 2013
  end-page: 660
  ident: bib11
  article-title: New genes as drivers of phenotypic evolution
  publication-title: Nat. Rev. Genet.
– volume: 18
  start-page: 71
  year: 2017
  end-page: 86
  ident: bib26
  article-title: Regulatory activities of transposable elements: from conflicts to benefits
  publication-title: Nat. Rev. Genet.
– volume: 18
  year: 2019
  ident: bib33
  article-title: FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
  publication-title: Lipids Health Dis.
– volume: 246
  start-page: 858
  year: 2017
  end-page: 866
  ident: bib19
  article-title: Hit pause: developmental arrest in annual killifishes and their close relatives
  publication-title: Dev. Dyn.
– volume: 574
  start-page: 359
  year: 2019
  end-page: 364
  ident: bib32
  article-title: Regulation of lifespan by neural excitation and REST
  publication-title: Nature
– volume: 102
  start-page: 4795
  year: 2005
  end-page: 4800
  ident: bib144
  article-title: An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 429
  start-page: 562
  year: 2004
  end-page: 566
  ident: bib87
  article-title: Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
  publication-title: Nature
– volume: 30
  start-page: 923
  year: 2014
  end-page: 930
  ident: bib142
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
– volume: 38
  start-page: 576
  year: 2010
  end-page: 589
  ident: bib27
  article-title: Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
  publication-title: Mol. Cell
– volume: 412
  start-page: 4089
  year: 2020
  end-page: 4099
  ident: bib45
  article-title: Optimization of mass spectrometry settings for steroidomic analysis in young and old killifish
  publication-title: Anal. Bioanal. Chem.
– volume: 583
  start-page: 425
  year: 2020
  end-page: 430
  ident: bib139
  article-title: Physiological blood-brain transport is impaired with age by a shift in transcytosis
  publication-title: Nature
– volume: 346
  start-page: 1007
  year: 2014
  end-page: 1012
  ident: bib66
  article-title: Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution
  publication-title: Science
– volume: 15
  start-page: 978
  year: 2016
  end-page: 980
  ident: bib61
  article-title: Has gene duplication impacted the evolution of Eutherian longevity?
  publication-title: Aging Cell
– volume: 2
  year: 2021
  ident: bib152
  article-title: clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
  publication-title: Innovation (Camb)
– volume: 14
  start-page: 708
  year: 2004
  end-page: 715
  ident: bib113
  article-title: Aligning multiple genomic sequences with the threaded blockset aligner
  publication-title: Genome Res.
– volume: 369
  year: 2020
  ident: bib70
  article-title: Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates
  publication-title: Science
– volume: 26
  start-page: 139
  year: 2010
  end-page: 140
  ident: bib117
  article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
  publication-title: Bioinformatics
– volume: 4
  year: 2004
  ident: bib36
  article-title: Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans
  publication-title: BMC Dev. Biol.
– year: 2013–2015
  ident: bib120
  article-title: RepeatMasker Open-4.0
– volume: 59
  start-page: 169
  year: 1968
  end-page: 187
  ident: bib12
  article-title: Evolution from fish to mammals by gene duplication
  publication-title: Hereditas
– year: 2007
  ident: bib111
  article-title: Improved Pairwise Alignment of Genomic DNA
– volume: 115
  start-page: 12763
  year: 2018
  end-page: 12768
  ident: bib73
  article-title: Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 496
  start-page: 498
  year: 2013
  end-page: 503
  ident: bib99
  article-title: The zebrafish reference genome sequence and its relationship to the human genome
  publication-title: Nature
– volume: 56
  start-page: 1417
  year: 2021
  end-page: 1429
  ident: bib72
  article-title: Lipid metabolism in adaptation to extreme nutritional challenges
  publication-title: Dev. Cell
– volume: 9
  year: 2008
  ident: bib110
  article-title: Model-based analysis of ChIP-Seq (MACS)
  publication-title: Genome Biol.
– volume: 26
  start-page: 181
  year: 2024
  end-page: 193
  ident: bib81
  article-title: FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy
  publication-title: Nat. Cell Biol.
– volume: 282
  year: 2015
  ident: bib18
  article-title: Convergent evolution of alternative developmental trajectories associated with diapause in African and South American killifish
  publication-title: Proc. Biol. Sci.
– volume: 1
  start-page: 841
  year: 2001
  end-page: 851
  ident: bib75
  article-title: A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
  publication-title: Dev. Cell
– volume: 105
  start-page: 6777
  year: 2008
  end-page: 6781
  ident: bib37
  article-title: Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 9
  year: 2020
  ident: bib34
  article-title: DAF-16/FoxO in Caenorhabditis elegans and its role in metabolic remodeling
  publication-title: Cells
– volume: 11
  start-page: 1396
  year: 2016
  end-page: 1413
  ident: bib129
  article-title: Laboratory breeding of the short-lived annual killifish Nothobranchius furzeri
  publication-title: Nat. Protoc.
– volume: 52
  start-page: 408
  year: 2020
  end-page: 422
  ident: bib46
  article-title: Metabolomics analysis of annual killifish (Austrofundulus limnaeus) embryos during aerial dehydration stress
  publication-title: Physiol. Genomics
– volume: 54
  start-page: 421
  year: 1999
  end-page: 431
  ident: bib128
  article-title: Husbandry of the annual killifish Austrofundulus limnaeus with special emphasis on the collection and rearing of embryos
  publication-title: Environmental Biology of Fishes
– volume: 10
  year: 2021
  ident: bib62
  article-title: Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk
  publication-title: eLife
– volume: 14
  start-page: 144
  year: 2013
  end-page: 161
  ident: bib112
  article-title: The UCSC genome browser and associated tools
  publication-title: Brief. Bioinform.
– volume: 164
  start-page: 45
  year: 2016
  end-page: 56
  ident: bib67
  article-title: Evolving new skeletal traits by cis-regulatory changes in bone morphogenetic proteins
  publication-title: Cell
– volume: 118
  year: 2021
  ident: bib80
  article-title: Lipid droplets in mammalian eggs are utilized during embryonic diapause
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 137
  start-page: 107
  year: 1994
  end-page: 120
  ident: bib78
  article-title: daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans
  publication-title: Genetics
– volume: 278
  start-page: 1319
  year: 1997
  end-page: 1322
  ident: bib85
  article-title: daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
  publication-title: Science
– volume: 8/2
  start-page: 474
  year: 2016
  end-page: 485
  ident: bib115
  article-title: Wenxuan ggfortify: unified Interface to Visualize Statistical Results of Popular R Packages
  publication-title: R J.
– volume: 11
  start-page: 1990
  year: 2019
  end-page: 2002
  ident: bib88
  article-title: Hepatic lipid droplet breakdown through lipolysis during hibernation in Chinese Soft-Shelled Turtle (Pelodiscus sinensis)
  publication-title: Aging (Albany, NY)
– volume: 8
  year: 2007
  ident: bib147
  article-title: Quantifying similarity between motifs
  publication-title: Genome Biol.
– volume: 163
  start-page: 1527
  year: 2015
  end-page: 1538
  ident: bib8
  article-title: Insights into sex chromosome evolution and aging from the genome of a short-lived fish
  publication-title: Cell
– volume: 10
  year: 2021
  ident: bib108
  article-title: Twelve years of SAMtools and BCFtools
  publication-title: GigaScience
– volume: 9
  start-page: 676
  year: 2012
  end-page: 682
  ident: bib140
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nat. Methods
– volume: 10
  start-page: 1213
  year: 2013
  end-page: 1218
  ident: bib23
  article-title: Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
  publication-title: Nat. Methods
– volume: 352
  start-page: 1009
  year: 2016
  end-page: 1013
  ident: bib16
  article-title: Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals
  publication-title: Science
– volume: 10
  start-page: 1213
  year: 2013
  ident: 10.1016/j.cell.2024.04.048_bib23
  article-title: Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2688
– volume: 32
  start-page: 543
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib2
  article-title: Nothobranchius furzeri: A Model for Aging Research and More
  publication-title: Trends Genet.
  doi: 10.1016/j.tig.2016.06.006
– volume: 26
  start-page: 318
  year: 1999
  ident: 10.1016/j.cell.2024.04.048_bib50
  article-title: The protective role of plasmalogens in iron-induced lipid peroxidation
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/S0891-5849(98)00221-4
– volume: 246
  start-page: 838
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib71
  article-title: The role of energetic reserves during embryonic development of an annual killifish
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.24528
– volume: 9
  start-page: 161
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib149
  article-title: Evolution and diversity of transposable elements in vertebrate genomes
  publication-title: Genome Biol. Evol.
  doi: 10.1093/gbe/evw264
– volume: 8
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib5
  article-title: Nothobranchius furzeri, an 'instant' fish from an ephemeral habitat
  publication-title: eLife
  doi: 10.7554/eLife.41548
– volume: 11
  start-page: 1396
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib129
  article-title: Laboratory breeding of the short-lived annual killifish Nothobranchius furzeri
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.080
– volume: 7
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib148
  article-title: The contribution of transposable elements to size variations between four teleost genomes
  publication-title: Mobile DNA
  doi: 10.1186/s13100-016-0059-7
– volume: 15
  start-page: 978
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib61
  article-title: Has gene duplication impacted the evolution of Eutherian longevity?
  publication-title: Aging Cell
  doi: 10.1111/acel.12503
– volume: 45
  start-page: 115
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib25
  article-title: Enhancer evolution and the origins of morphological novelty
  publication-title: Curr. Opin. Genet. Dev.
  doi: 10.1016/j.gde.2017.04.006
– volume: 115
  start-page: 12763
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib73
  article-title: Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1804590115
– volume: 1150
  start-page: 81
  year: 2014
  ident: 10.1016/j.cell.2024.04.048_bib143
  article-title: Use model-based analysis of ChIP-Seq (MACS) to analyze short reads generated by sequencing protein-DNA interactions in embryonic stem cells
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-0512-6_4
– volume: 29
  start-page: 1157
  year: 1988
  ident: 10.1016/j.cell.2024.04.048_bib89
  article-title: Lipoprotein[a] is the major apoB-containing lipoprotein in the plasma of a hibernator, the hedgehog (Erinaceus europaeus)
  publication-title: J. Lipid Res.
  doi: 10.1016/S0022-2275(20)38452-2
– volume: 31
  start-page: 2382
  year: 2015
  ident: 10.1016/j.cell.2024.04.048_bib118
  article-title: ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv145
– volume: 10
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib121
  article-title: MutationalPatterns: comprehensive genome-wide analysis of mutational processes
  publication-title: Genome Med.
  doi: 10.1186/s13073-018-0539-0
– volume: 583
  start-page: 425
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib139
  article-title: Physiological blood-brain transport is impaired with age by a shift in transcytosis
  publication-title: Nature
  doi: 10.1038/s41586-020-2453-z
– volume: 99
  start-page: 242
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib21
  article-title: The history of the discovery of embryonic diapause in mammals
  publication-title: Biol. Reprod.
  doi: 10.1093/biolre/ioy112
– volume: 62
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib91
  article-title: Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos)
  publication-title: J. Lipid Res.
  doi: 10.1016/j.jlr.2021.100065
– volume: 10
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib54
  article-title: A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes
  publication-title: eLife
  doi: 10.7554/eLife.59683
– volume: 14
  start-page: 1512
  year: 2000
  ident: 10.1016/j.cell.2024.04.048_bib74
  article-title: daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.12.1512
– volume: 6
  year: 2011
  ident: 10.1016/j.cell.2024.04.048_bib90
  article-title: Cholesterol and lipoprotein dynamics in a hibernating mammal
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0029111
– volume: 7
  year: 2009
  ident: 10.1016/j.cell.2024.04.048_bib57
  article-title: Wings, horns, and butterfly eyespots: how do complex traits evolve?
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1000037
– volume: 14
  start-page: 790
  year: 1997
  ident: 10.1016/j.cell.2024.04.048_bib17
  article-title: A molecular phylogeny for aplocheiloid fishes (Atherinomorpha, Cyprinodontiformes): the role of vicariance and the origins of annualism
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/oxfordjournals.molbev.a025819
– volume: 564
  start-page: 64
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib24
  article-title: Amphioxus functional genomics and the origins of vertebrate gene regulation
  publication-title: Nature
  doi: 10.1038/s41586-018-0734-6
– volume: 56
  start-page: 1417
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib72
  article-title: Lipid metabolism in adaptation to extreme nutritional challenges
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2021.02.024
– volume: 1822
  start-page: 1442
  year: 2012
  ident: 10.1016/j.cell.2024.04.048_bib51
  article-title: Functions of plasmalogen lipids in health and disease
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbadis.2012.05.008
– volume: 375
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib69
  article-title: Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
  doi: 10.1098/rstb.2019.0347
– volume: 48
  start-page: 193
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib41
  article-title: REST, a master transcriptional regulator in neurodegenerative disease
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2017.12.008
– volume: 2023
  year: 2023
  ident: 10.1016/j.cell.2024.04.048_bib131
  article-title: Husbandry of the African Turquoise killifish Nothobranchius furzeri
  publication-title: Cold Spring Harb. Protoc.
  doi: 10.1101/pdb.prot107738
– volume: 30
  start-page: 3610
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib14
  article-title: Ancestral transoceanic colonization and recent population reduction in a nonannual killifish from the Seychelles archipelago
  publication-title: Mol. Ecol.
  doi: 10.1111/mec.15982
– volume: 14
  start-page: 144
  year: 2013
  ident: 10.1016/j.cell.2024.04.048_bib112
  article-title: The UCSC genome browser and associated tools
  publication-title: Brief. Bioinform.
  doi: 10.1093/bib/bbs038
– volume: 11
  start-page: 2010
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib136
  article-title: Efficient genome engineering approaches for the short-lived African turquoise killifish
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.103
– volume: 111
  start-page: 6321
  year: 2011
  ident: 10.1016/j.cell.2024.04.048_bib39
  article-title: PPARs and lipid ligands in inflammation and metabolism
  publication-title: Chem. Rev.
  doi: 10.1021/cr2001355
– volume: 14
  year: 2013
  ident: 10.1016/j.cell.2024.04.048_bib83
  article-title: Molecular signatures of mammalian hibernation: comparisons with alternative phenotypes
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-567
– volume: 507
  start-page: 448
  year: 2014
  ident: 10.1016/j.cell.2024.04.048_bib30
  article-title: REST and stress resistance in ageing and Alzheimer's disease
  publication-title: Nature
  doi: 10.1038/nature13163
– volume: 26
  start-page: 181
  year: 2024
  ident: 10.1016/j.cell.2024.04.048_bib81
  article-title: FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-023-01325-3
– volume: 2
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib82
  article-title: Hibernation induces widespread transcriptional remodeling in metabolic tissues of the grizzly bear
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-019-0574-4
– volume: 9
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib34
  article-title: DAF-16/FoxO in Caenorhabditis elegans and its role in metabolic remodeling
  publication-title: Cells
  doi: 10.3390/cells9010109
– volume: 46
  start-page: 112
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib53
  article-title: A rapid method for directed gene knockout for screening in G0 zebrafish
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.06.003
– volume: 213
  start-page: 3280
  year: 2010
  ident: 10.1016/j.cell.2024.04.048_bib133
  article-title: Alternative developmental pathways associated with diapause regulated by temperature and maternal influences in embryos of the annual killifish Austrofundulus limnaeus
  publication-title: J. Exp. Biol.
  doi: 10.1242/jeb.045906
– volume: 8
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib98
  article-title: Centromere evolution and CpG methylation during vertebrate speciation
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01982-7
– year: 2007
  ident: 10.1016/j.cell.2024.04.048_bib111
– volume: 18
  start-page: 71
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib26
  article-title: Regulatory activities of transposable elements: from conflicts to benefits
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg.2016.139
– volume: 20
  start-page: 126
  year: 2008
  ident: 10.1016/j.cell.2024.04.048_bib35
  article-title: FoxO transcription factors in the maintenance of cellular homeostasis during aging
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2008.02.005
– volume: 8
  year: 2007
  ident: 10.1016/j.cell.2024.04.048_bib147
  article-title: Quantifying similarity between motifs
  publication-title: Genome Biol.
  doi: 10.1186/gb-2007-8-2-r24
– volume: 118
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib80
  article-title: Lipid droplets in mammalian eggs are utilized during embryonic diapause
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2018362118
– volume: 246
  start-page: 779
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib132
  article-title: Embryonic development of the annual killifish Austrofundulus limnaeus: an emerging model for ecological and evolutionary developmental biology research and instruction
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.24513
– volume: 246
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib20
  article-title: Annual killifishes as model systems for advancing understanding of evolution and developmental biology
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.24594
– volume: 16
  year: 2015
  ident: 10.1016/j.cell.2024.04.048_bib100
  article-title: OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy
  publication-title: Genome Biol.
  doi: 10.1186/s13059-015-0721-2
– volume: 429
  start-page: 562
  year: 2004
  ident: 10.1016/j.cell.2024.04.048_bib87
  article-title: Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
  publication-title: Nature
  doi: 10.1038/nature02549
– year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib130
  article-title: A Protocol for Laboratory Housing of Turquoise killifish (Nothobranchius furzeri)
  publication-title: J. Vis. Exp.
  doi: 10.3791/57073-v
– volume: 4
  year: 2004
  ident: 10.1016/j.cell.2024.04.048_bib36
  article-title: Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-4-11
– volume: 52
  start-page: 236
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib22
  article-title: Metabolic control over mTOR-dependent diapause-like state
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2019.12.018
– volume: 32
  start-page: 3047
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib104
  article-title: MultiQC: summarize analysis results for multiple tools and samples in a single report
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btw354
– volume: 119
  year: 2022
  ident: 10.1016/j.cell.2024.04.048_bib38
  article-title: FoxO induces pupal diapause by decreasing TGFbeta signaling
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.2210404119
– volume: 496
  start-page: 498
  year: 2013
  ident: 10.1016/j.cell.2024.04.048_bib99
  article-title: The zebrafish reference genome sequence and its relationship to the human genome
  publication-title: Nature
  doi: 10.1038/nature12111
– volume: 574
  start-page: 359
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib32
  article-title: Regulation of lifespan by neural excitation and REST
  publication-title: Nature
  doi: 10.1038/s41586-019-1647-8
– volume: 30
  start-page: 923
  year: 2014
  ident: 10.1016/j.cell.2024.04.048_bib142
  article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
– volume: 484
  start-page: 55
  year: 2012
  ident: 10.1016/j.cell.2024.04.048_bib64
  article-title: The genomic basis of adaptive evolution in threespine sticklebacks
  publication-title: Nature
  doi: 10.1038/nature10944
– volume: 11
  start-page: 1990
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib88
  article-title: Hepatic lipid droplet breakdown through lipolysis during hibernation in Chinese Soft-Shelled Turtle (Pelodiscus sinensis)
  publication-title: Aging (Albany, NY)
  doi: 10.18632/aging.101887
– volume: 6
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib28
  article-title: Robust inference of positive selection on regulatory sequences in the human brain
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abc9863
– volume: 8
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib68
  article-title: Predominance of cis-regulatory changes in parallel expression divergence of sticklebacks
  publication-title: eLife
  doi: 10.7554/eLife.43785
– volume: 26
  start-page: 139
  year: 2010
  ident: 10.1016/j.cell.2024.04.048_bib117
  article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
– volume: 107
  start-page: 22172
  year: 2010
  ident: 10.1016/j.cell.2024.04.048_bib59
  article-title: Old gene duplication facilitates origin and diversification of an innovative communication system--twice
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1011803107
– volume: 366
  start-page: 461
  year: 1993
  ident: 10.1016/j.cell.2024.04.048_bib76
  article-title: A C. elegans mutant that lives twice as long as wild type
  publication-title: Nature
  doi: 10.1038/366461a0
– volume: 178
  start-page: 385
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib29
  article-title: Relaxed selection limits lifespan by increasing mutation load
  publication-title: Cell
  doi: 10.1016/j.cell.2019.06.004
– volume: 20
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib15
  article-title: OrthoFinder: phylogenetic orthology inference for comparative genomics
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1832-y
– volume: 282
  year: 2015
  ident: 10.1016/j.cell.2024.04.048_bib18
  article-title: Convergent evolution of alternative developmental trajectories associated with diapause in African and South American killifish
  publication-title: Proc. Biol. Sci.
– volume: 139
  start-page: 1567
  year: 1995
  ident: 10.1016/j.cell.2024.04.048_bib77
  article-title: Genes that regulate both development and longevity in Caenorhabditis elegans
  publication-title: Genetics
  doi: 10.1093/genetics/139.4.1567
– volume: 10
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib108
  article-title: Twelve years of SAMtools and BCFtools
  publication-title: GigaScience
  doi: 10.1093/gigascience/giab008
– volume: 412
  start-page: 4089
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib45
  article-title: Optimization of mass spectrometry settings for steroidomic analysis in young and old killifish
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-020-02640-6
– year: 2010
  ident: 10.1016/j.cell.2024.04.048_bib103
– volume: 59
  start-page: 169
  year: 1968
  ident: 10.1016/j.cell.2024.04.048_bib12
  article-title: Evolution from fish to mammals by gene duplication
  publication-title: Hereditas
  doi: 10.1111/j.1601-5223.1968.tb02169.x
– volume: 9
  start-page: 676
  year: 2012
  ident: 10.1016/j.cell.2024.04.048_bib140
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2019
– volume: 23
  start-page: 257
  year: 2007
  ident: 10.1016/j.cell.2024.04.048_bib126
  article-title: Using GOstats to test gene lists for GO term association
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btl567
– volume: 48
  start-page: D682
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib141
  article-title: Ensembl 2020
  publication-title: Nucleic Acids Res.
– volume: 137
  start-page: 107
  year: 1994
  ident: 10.1016/j.cell.2024.04.048_bib78
  article-title: daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans
  publication-title: Genetics
  doi: 10.1093/genetics/137.1.107
– volume: 24
  start-page: 1586
  year: 2007
  ident: 10.1016/j.cell.2024.04.048_bib122
  article-title: PAML 4: phylogenetic analysis by maximum likelihood
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msm088
– volume: 47
  start-page: W171
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib127
  article-title: CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz365
– volume: 215
  start-page: 403
  year: 1990
  ident: 10.1016/j.cell.2024.04.048_bib101
  article-title: Basic local alignment search tool
  publication-title: J. Mol. Biol.
  doi: 10.1016/S0022-2836(05)80360-2
– volume: 14
  start-page: 708
  year: 2004
  ident: 10.1016/j.cell.2024.04.048_bib113
  article-title: Aligning multiple genomic sequences with the threaded blockset aligner
  publication-title: Genome Res.
  doi: 10.1101/gr.1933104
– volume: 167
  start-page: 1170
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib55
  article-title: Ever-changing landscapes: transcriptional enhancers in development and evolution
  publication-title: Cell
  doi: 10.1016/j.cell.2016.09.018
– volume: 2024
  year: 2024
  ident: 10.1016/j.cell.2024.04.048_bib137
  article-title: Chromatin Accessibility Profiling and Data Analysis Using ATAC-seq in Nothobranchius furzeri
  publication-title: Cold Spring Harb. Protoc.
  doi: 10.1101/pdb.prot107747
– volume: 18
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib33
  article-title: FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
  publication-title: Lipids Health Dis.
  doi: 10.1186/s12944-019-1132-2
– volume: 369
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib70
  article-title: Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates
  publication-title: Science
  doi: 10.1126/science.aaz3090
– volume: 105
  start-page: 6777
  year: 2008
  ident: 10.1016/j.cell.2024.04.048_bib37
  article-title: Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0802067105
– year: 2011
  ident: 10.1016/j.cell.2024.04.048_bib116
– volume: 17
  start-page: 1797
  year: 2007
  ident: 10.1016/j.cell.2024.04.048_bib145
  article-title: 28-way vertebrate alignment and conservation track in the UCSC Genome Browser
  publication-title: Genome Res.
  doi: 10.1101/gr.6761107
– volume: 240
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib94
  article-title: Regulation of metabolism during hibernation in brown bears (Ursus arctos): involvement of cortisol, PGC-1alpha and AMPK in adipose tissue and skeletal muscle
  publication-title: Comp. Biochem. Physiol. A Mol. Integr. Physiol.
  doi: 10.1016/j.cbpa.2019.110591
– volume: 246
  start-page: 858
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib19
  article-title: Hit pause: developmental arrest in annual killifishes and their close relatives
  publication-title: Dev. Dyn.
  doi: 10.1002/dvdy.24507
– volume: 39
  start-page: 309
  year: 2005
  ident: 10.1016/j.cell.2024.04.048_bib10
  article-title: Orthologs, paralogs, and evolutionary genomics
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev.genet.39.073003.114725
– volume: 352
  start-page: 1009
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib16
  article-title: Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals
  publication-title: Science
  doi: 10.1126/science.aad8411
– volume: 1861
  start-page: 793
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib48
  article-title: Lipid droplets, lipophagy, and beyond
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbalip.2015.12.010
– volume: 15
  year: 2014
  ident: 10.1016/j.cell.2024.04.048_bib102
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 2
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib152
  article-title: clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
  publication-title: Innovation (Camb)
– volume: 9
  year: 2008
  ident: 10.1016/j.cell.2024.04.048_bib110
  article-title: Model-based analysis of ChIP-Seq (MACS)
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-9-r137
– volume: 29
  start-page: 24
  year: 2011
  ident: 10.1016/j.cell.2024.04.048_bib114
  article-title: Integrative genomics viewer
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1754
– volume: 54
  start-page: 541
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib31
  article-title: Brain REST/NRSF is not only a silent repressor but also an active protector
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-015-9658-4
– volume: 52
  start-page: 408
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib46
  article-title: Metabolomics analysis of annual killifish (Austrofundulus limnaeus) embryos during aerial dehydration stress
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00072.2020
– volume: 481
  start-page: 389
  year: 2012
  ident: 10.1016/j.cell.2024.04.048_bib146
  article-title: Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
  publication-title: Nature
  doi: 10.1038/nature10730
– volume: 10
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib62
  article-title: Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk
  publication-title: eLife
  doi: 10.7554/eLife.65041
– volume: 15
  start-page: 221
  year: 2014
  ident: 10.1016/j.cell.2024.04.048_bib65
  article-title: Evolution of transcription factor binding in metazoans - mechanisms and functional implications
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3481
– volume: 164
  start-page: 45
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib67
  article-title: Evolving new skeletal traits by cis-regulatory changes in bone morphogenetic proteins
  publication-title: Cell
  doi: 10.1016/j.cell.2015.12.007
– volume: 12
  year: 2011
  ident: 10.1016/j.cell.2024.04.048_bib123
  article-title: Proteinortho: detection of (co-)orthologs in large-scale analysis
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-12-124
– volume: 367
  start-page: 870
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib6
  article-title: Vertebrate diapause preserves organisms long term through Polycomb complex members
  publication-title: Science
  doi: 10.1126/science.aaw2601
– volume: 38
  start-page: 576
  year: 2010
  ident: 10.1016/j.cell.2024.04.048_bib27
  article-title: Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2010.05.004
– volume: 28
  start-page: R822
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib3
  article-title: Extremely rapid maturation of a wild African annual fish
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2018.06.031
– volume: 278
  start-page: 1319
  year: 1997
  ident: 10.1016/j.cell.2024.04.048_bib85
  article-title: daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
  publication-title: Science
  doi: 10.1126/science.278.5341.1319
– volume: 17
  start-page: 297
  year: 2022
  ident: 10.1016/j.cell.2024.04.048_bib92
  article-title: Phenotypic changes in the metabolic profile and adiponectin activity during seasonal fattening and hibernation in female Daurian ground squirrels (Spermophilus dauricus)
  publication-title: Integr. Zool.
  doi: 10.1111/1749-4877.12504
– year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib150
  article-title: The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection
  publication-title: bioRxiv
– year: 2013
  ident: 10.1016/j.cell.2024.04.048_bib120
– volume: 74
  start-page: 186
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib52
  article-title: Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease
  publication-title: Prog. Lipid Res.
  doi: 10.1016/j.plipres.2019.04.003
– volume: 18
  start-page: 695
  year: 2008
  ident: 10.1016/j.cell.2024.04.048_bib60
  article-title: Genomic evolution of the placenta using co-option and duplication and divergence
  publication-title: Genome Res.
  doi: 10.1101/gr.071407.107
– volume: 1507
  start-page: 59
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib135
  article-title: Assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-Seq) protocol for zebrafish embryos
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-6518-2_5
– volume: 91
  start-page: 511
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib1
  article-title: From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology
  publication-title: Biol. Rev. Camb. Philos. Soc.
  doi: 10.1111/brv.12183
– volume: 17
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib4
  article-title: The African turquoise killifish: A research organism to study vertebrate aging and diapause
  publication-title: Aging Cell
  doi: 10.1111/acel.12757
– volume: 346
  start-page: 1007
  year: 2014
  ident: 10.1016/j.cell.2024.04.048_bib66
  article-title: Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution
  publication-title: Science
  doi: 10.1126/science.1246426
– volume: 9
  start-page: 938
  year: 2008
  ident: 10.1016/j.cell.2024.04.048_bib13
  article-title: Turning a hobby into a job: how duplicated genes find new functions
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2482
– volume: 32
  year: 2020
  ident: 10.1016/j.cell.2024.04.048_bib84
  article-title: Beaver and naked mole rat genomes reveal common paths to longevity
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.107949
– volume: 41
  year: 2013
  ident: 10.1016/j.cell.2024.04.048_bib106
  article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt214
– volume: 163
  start-page: 1527
  year: 2015
  ident: 10.1016/j.cell.2024.04.048_bib8
  article-title: Insights into sex chromosome evolution and aging from the genome of a short-lived fish
  publication-title: Cell
  doi: 10.1016/j.cell.2015.10.071
– volume: 27
  start-page: 1461
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib58
  article-title: The evolution of duplicate gene expression in mammalian organs
  publication-title: Genome Res.
  doi: 10.1101/gr.215566.116
– volume: 7
  year: 2009
  ident: 10.1016/j.cell.2024.04.048_bib97
  article-title: Lineage-specific biology revealed by a finished genome assembly of the mouse
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1000112
– volume: 29
  start-page: 15
  year: 2013
  ident: 10.1016/j.cell.2024.04.048_bib105
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
– volume: 8/2
  start-page: 474
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib115
  article-title: Wenxuan ggfortify: unified Interface to Visualize Statistical Results of Popular R Packages
  publication-title: R J.
  doi: 10.32614/RJ-2016-060
– volume: 43
  start-page: W7
  year: 2015
  ident: 10.1016/j.cell.2024.04.048_bib125
  article-title: GUIDANCE2: accurate detection of unreliable alignment regions accounting for the uncertainty of multiple parameters
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv318
– volume: 44
  start-page: W160
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib109
  article-title: deepTools2: a next generation web server for deep-sequencing data analysis
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw257
– volume: 202
  start-page: 2567
  year: 1999
  ident: 10.1016/j.cell.2024.04.048_bib134
  article-title: The bioenergetics of embryonic diapause in an annual killifish, austrofundulus limnaeus
  publication-title: J. Exp. Biol.
  doi: 10.1242/jeb.202.19.2567
– volume: 160
  start-page: 554
  year: 2015
  ident: 10.1016/j.cell.2024.04.048_bib56
  article-title: Enhancer evolution across 20 mammalian species
  publication-title: Cell
  doi: 10.1016/j.cell.2015.01.006
– volume: 13
  start-page: 577
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib151
  article-title: Data-driven hypothesis weighting increases detection power in genome-scale multiple testing
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3885
– volume: 1
  start-page: 841
  year: 2001
  ident: 10.1016/j.cell.2024.04.048_bib75
  article-title: A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(01)00085-5
– volume: 10
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib42
  article-title: REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion
  publication-title: eLife
  doi: 10.7554/eLife.69058
– volume: 1079
  start-page: 155
  year: 2014
  ident: 10.1016/j.cell.2024.04.048_bib124
  article-title: Phylogeny-aware alignment with PRANK
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-62703-646-7_10
– volume: 584
  start-page: 2183
  year: 2010
  ident: 10.1016/j.cell.2024.04.048_bib49
  article-title: Something worth dyeing for: molecular tools for the dissection of lipid metabolism in Caenorhabditis elegans
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2010.03.046
– volume: 50
  start-page: 437
  year: 2012
  ident: 10.1016/j.cell.2024.04.048_bib43
  article-title: FoxO1, the transcriptional chief of staff of energy metabolism
  publication-title: Bone
  doi: 10.1016/j.bone.2011.06.034
– volume: 54
  start-page: 421
  year: 1999
  ident: 10.1016/j.cell.2024.04.048_bib128
  article-title: Husbandry of the annual killifish Austrofundulus limnaeus with special emphasis on the collection and rearing of embryos
  publication-title: Environmental Biology of Fishes
  doi: 10.1023/A:1007598320759
– volume: 102
  start-page: 4795
  year: 2005
  ident: 10.1016/j.cell.2024.04.048_bib144
  article-title: An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0409882102
– volume: 22
  start-page: 577
  year: 2012
  ident: 10.1016/j.cell.2024.04.048_bib96
  article-title: Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis
  publication-title: Genome Res.
  doi: 10.1101/gr.133009.111
– volume: 288
  year: 2021
  ident: 10.1016/j.cell.2024.04.048_bib63
  article-title: Positive selection and gene duplications in tumour suppressor genes reveal clues about how cetaceans resist cancer
  publication-title: Proc. Biol. Sci.
– volume: 9
  start-page: 357
  year: 2012
  ident: 10.1016/j.cell.2024.04.048_bib107
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 144
  start-page: 3199
  year: 2017
  ident: 10.1016/j.cell.2024.04.048_bib7
  article-title: The enigma of embryonic diapause
  publication-title: Development
  doi: 10.1242/dev.148213
– volume: 20
  start-page: 83
  year: 2019
  ident: 10.1016/j.cell.2024.04.048_bib44
  article-title: Age-related changes in mitochondrial membrane composition of Nothobranchius furzeri.: comparison with a longer-living Nothobranchius species
  publication-title: Biogerontology
  doi: 10.1007/s10522-018-9778-0
– volume: 587
  start-page: 1863
  year: 2009
  ident: 10.1016/j.cell.2024.04.048_bib79
  article-title: A role for nuclear receptors in mammalian hibernation
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2008.167692
– volume: 144
  start-page: 2201
  year: 2003
  ident: 10.1016/j.cell.2024.04.048_bib40
  article-title: Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors
  publication-title: Endocrinology
  doi: 10.1210/en.2003-0288
– volume: 53
  start-page: 124
  year: 2014
  ident: 10.1016/j.cell.2024.04.048_bib47
  article-title: Regulation of energy metabolism by long-chain fatty acids
  publication-title: Prog. Lipid Res.
  doi: 10.1016/j.plipres.2013.12.001
– volume: 14
  start-page: 1655
  year: 2016
  ident: 10.1016/j.cell.2024.04.048_bib93
  article-title: The gut microbiota modulates energy metabolism in the hibernating brown bear Ursus arctos
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.01.026
– volume: 14
  start-page: 645
  year: 2013
  ident: 10.1016/j.cell.2024.04.048_bib11
  article-title: New genes as drivers of phenotypic evolution
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3521
– volume: 221
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib95
  article-title: Diapause-associated changes in the lipid and metabolite profiles of the Asian tiger mosquito, Aedes albopictus
  publication-title: J. Exp. Biol.
– volume: 389
  start-page: 994
  year: 1997
  ident: 10.1016/j.cell.2024.04.048_bib86
  article-title: The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
  publication-title: Nature
  doi: 10.1038/40194
– volume: 19
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib9
  article-title: The genome of Austrofundulus limnaeus offers insights into extreme vertebrate stress tolerance and embryonic development
  publication-title: BMC Genomics
  doi: 10.1186/s12864-018-4539-7
– volume: 37
  start-page: W202
  year: 2009
  ident: 10.1016/j.cell.2024.04.048_bib119
  article-title: MEME SUITE: tools for motif discovery and searching
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkp335
– volume: 8
  year: 2018
  ident: 10.1016/j.cell.2024.04.048_bib138
  article-title: Cross-platform comparison of untargeted and targeted lipidomics approaches on aging mouse plasma
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-35807-4
SSID ssj0008555
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Snippet Suspended animation states allow organisms to survive extreme environments. The African turquoise killifish has evolved diapause as a form of suspended...
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crossref
elsevier
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StartPage 3338
SubjectTerms aging
Animals
Biological Evolution
chromatin
comparative genomics
complex trait evolution
diapause
Diapause - genetics
drought
Embryo, Nonmammalian - metabolism
epigenetics
epigenomics
evolution
Female
Fish Proteins - genetics
Fundulidae - genetics
Fundulidae - metabolism
gene expression
Gene Expression Regulation, Developmental
genes
killifish
Killifishes - genetics
Killifishes - metabolism
lipid composition
lipid metabolism
Lipid Metabolism - genetics
lipidomics
Male
metabolomics
multiomics
species
suspended animation
Title Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape
URI https://dx.doi.org/10.1016/j.cell.2024.04.048
https://www.ncbi.nlm.nih.gov/pubmed/38810644
https://www.proquest.com/docview/3062532780
https://www.proquest.com/docview/3206185373
Volume 187
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