Physicochemical studies of a newly synthesized molecule, 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione (JSH18) for topical formulations - Kim, Sujin; Jung, Sang-Hun; Cho, Cheong-Weon (Archives of pharmacal research, 2008)
Keywords: Administration, Topical; Animals; Calorimetry, Differential Scanning; Cell Survival - drug effects; cell viability; cells; Chemistry, Pharmaceutical; Chemistry, Physical; cytotoxicity; Dermatologic Agents - chemistry; Dermatologic Agents - metabolism; Dermatologic Agents - pharmacology; differential scanning calorimetry; formulations; grinding; humans; In Vitro Techniques; isopropyl alcohol; keratinocytes; Keratinocytes - drug effects; Keratinocytes - metabolism; Male; Medicine; melanin; melanins; Mice; Microscopy, Electron, Scanning; Octanols - chemistry; Pharmacology/Toxicology; Pharmacy; physicochemical properties; pyrrolidones; Quinazolines - chemistry; Quinazolines - metabolism; Quinazolines - pharmacology; Rats; Rats, Sprague-Dawley; Research Article; scanning electron microscopy; Skin - metabolism; Solubility; solubilization; viability; Water - chemistry; 약학; Melanin synthesis inhibitor; Cell viability; Topical formulations; 6-Methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione; Preformulation; Solubility