Safety of dietary supplementation with arginine in adult humans
Previous studies with animals and humans have shown beneficial effects of dietary supplementation with l -arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a rando...
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| Published in | Amino acids Vol. 50; no. 9; pp. 1215 - 1229 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Vienna
Springer Vienna
01.09.2018
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0939-4451 1438-2199 1438-2199 |
| DOI | 10.1007/s00726-018-2594-7 |
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| Abstract | Previous studies with animals and humans have shown beneficial effects of dietary supplementation with
l
-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m
2
. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (
P
< 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (
P
< 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans. |
|---|---|
| AbstractList | Previous studies with animals and humans have shown beneficial effects of dietary supplementation with L-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m
. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (P < 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (P < 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans. Previous studies with animals and humans have shown beneficial effects of dietary supplementation with l-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m2. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (P < 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (P < 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans. Previous studies with animals and humans have shown beneficial effects of dietary supplementation with L-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m². A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (P < 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (P < 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans. Previous studies with animals and humans have shown beneficial effects of dietary supplementation with l -arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m 2 . A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased ( P < 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced ( P < 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans. Previous studies with animals and humans have shown beneficial effects of dietary supplementation with L-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m2. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (P < 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (P < 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans.Previous studies with animals and humans have shown beneficial effects of dietary supplementation with L-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m2. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (P < 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (P < 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans. |
| Author | Wilborn, Colin D. McNeal, Catherine J. Meininger, Cynthia J. Tekwe, Carmen D. Wu, Guoyao |
| Author_xml | – sequence: 1 givenname: Catherine J. surname: McNeal fullname: McNeal, Catherine J. organization: Department of Internal Medicine, Baylor Scott & White Health – sequence: 2 givenname: Cynthia J. surname: Meininger fullname: Meininger, Cynthia J. organization: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center – sequence: 3 givenname: Colin D. surname: Wilborn fullname: Wilborn, Colin D. organization: Department of Exercise and Sport Science, University of Mary Hardin-Baylor – sequence: 4 givenname: Carmen D. surname: Tekwe fullname: Tekwe, Carmen D. organization: Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M Health Science Center – sequence: 5 givenname: Guoyao surname: Wu fullname: Wu, Guoyao email: g-wu@tamu.edu organization: Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Department of Animal Science and Faculty of Nutrition, Texas A&M University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29858688$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0378-4347(00)00328-5 10.1152/ajpendo.00284.2012 10.1038/oby.2000.32 10.1016/j.yrtph.2008.01.004 10.1183/09031936.04.00086104 10.1152/ajpendo.00002.2006 10.1007/s00726-016-2256-6 10.1042/cs0960199 10.1093/jn/137.12.2680 10.1007/s00726-015-1921-5 10.1007/s00726-015-2012-3 10.1007/s00726-009-0334-8 10.1038/sj.jhh.1002016 10.2741/3792 10.1007/s00726-015-2031-0 10.1001/jama.295.1.58 10.1152/ajpendo.1995.269.5.E884 10.1177/1535370215587913 10.1093/jn/138.5.867 10.1111/j.1432-1033.1985.tb08824.x 10.1172/JCI115987 10.1093/jn/135.4.714 10.1007/s00726-015-1962-9 10.3390/nu8060320 10.1016/S0076-6879(07)00810-5 10.1201/b14661 10.1093/jn/137.6.1646S 10.1007/s00726-015-2022-1 10.1007/s00726-015-2145-4 10.1007/s00726-015-2055-5 10.3945/an.116.012971 10.1007/s00726-017-2399-0 10.3945/jn.116.234740 10.1177/0148607186010002227 10.1042/bj3120717 10.1055/s-2007-971137 10.1007/s00726-010-0598-z 10.1093/oxfordjournals.aje.a115835 10.1007/s00726-017-2420-7 10.1038/ejcn.2016.266 10.1007/s00726-015-2017-y 10.1186/s12933-017-0656-x 10.1146/annurev.pharmtox.41.1.79 10.1093/jn/134.10.2880S 10.1146/annurev.nutr.27.061406.093621 10.1093/jn/134.10.2752S 10.1016/S1095-6433(00)00196-3 10.3945/jn.108.096362 10.1007/s00726-008-0155-1 10.1016/j.jnutbio.2004.03.005 10.2741/4610 10.1093/jn/134.10.2888S 10.1007/s00726-015-1960-y 10.1007/s00726-015-1993-2 10.1016/j.appet.2017.02.025 10.1007/s00726-009-0246-7 10.1097/00005344-199607000-00023 10.1007/s00726-016-2245-9 10.1093/jn/137.6.1673S 10.1007/s00125-005-0066-6 10.1016/S2213-8587(13)70062-7 10.1093/jn/137.6.1693S 10.1016/S0753-3322(02)00273-1 10.1007/s00726-008-0210-y 10.1016/j.jnutbio.2011.06.012 10.1172/JCI118632 10.1093/jn/130.11.2626 10.1093/jn/133.6.2021S 10.1042/bj3360001 10.1093/jn/137.6.1602S 10.3390/nu8070430 10.1007/s00125-015-3844-9 10.1152/ajpendo.1993.265.4.E532 10.1080/10915810490435622 10.1007/s00726-016-2251-y 10.1007/s00726-017-2409-2 10.1016/0167-4889(89)90042-6 10.3945/an.115.010850 10.3109/19390211.2013.859216 10.1016/S0002-8223(21)00707-0 |
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| PublicationDate | 20180900 2018-9-00 2018-Sep 20180901 |
| PublicationDateYYYYMMDD | 2018-09-01 |
| PublicationDate_xml | – month: 9 year: 2018 text: 20180900 |
| PublicationDecade | 2010 |
| PublicationPlace | Vienna |
| PublicationPlace_xml | – name: Vienna – name: Austria |
| PublicationSubtitle | The Forum for Amino Acid, Peptide and Protein Research |
| PublicationTitle | Amino acids |
| PublicationTitleAbbrev | Amino Acids |
| PublicationTitleAlternate | Amino Acids |
| PublicationYear | 2018 |
| Publisher | Springer Vienna Springer Nature B.V |
| Publisher_xml | – name: Springer Vienna – name: Springer Nature B.V |
| References | Buchman, O’Brien, Ou, Rognerud, Alvarez, Dennis, Ahn (CR9) 1999; 20 Grimble (CR23) 2007; 137 Jobgen, Meininger, Jobgen, Li, Lee, Smith, Spencer, Fried, Wu (CR36) 2009; 139 Meijer, Lof, Ramos, Verhoeven (CR52) 1985; 148 Ma, Han, Li, Hu, Gilbreath, Bazer, Wu (CR46) 2017; 49 Pahlavani, Entezari, Nasiri, Miri, Rezaie, Bagheri-Bidakhavidi, Sadeghi (CR57) 2017; 71 Li, Meininger, Wu (CR41) 2000; 746 Luiking, Ten Have, Wolfe, Deutz (CR45) 2012; 303 Shao, Hathcock (CR63) 2008; 50 Jani, Bulpitt, Rajkumar (CR35) 2006; 20 Hu, Li, Rezaei, Meininger, McNeal, Wu (CR33) 2015; 47 Stefan, Häring, Hu, Schulze (CR65) 2013; 1 Barbul (CR1) 1986; 10 Yang, Wu, Jia, Dahanayaka, Feng, Meininger, McNeal, Wu (CR84) 2015; 47 Hou, Hu, Jia, Nawaratna, Che, Wang, Bazer, Wu (CR32) 2016; 48 Li, Meininger, Bazer, Wu (CR42) 2016; 48 Blachier, Davila, Benamouzig, Tome (CR5) 2011; 16 Flynn, Meininger, Haynes, Wu (CR19) 2002; 56 Hou, Yao, Yin, Wu (CR31) 2016; 7 Wu, Collins, Perkins-Veazie, Siddiq, Dolan, Kelly, Heaps, Meininger (CR81) 2007; 137 Block, Thompson, Hartman, Larkin, Guire (CR6) 1992; 92 Wu, Bazer, Cudd, Jobgen, Kim, Lassala, Li, Matis, Meininger, Spencer (CR80) 2007; 137 Haghikia, Yanchev, Kayacelebi, Hanff, Bledau, Widera, Sonnenschein, Haghikia, Weissenborn, Bauersachs, Bavendiek, Tsikas (CR24) 2017; 49 Hou, Wu (CR28) 2017; 8 Wu, Bazer, Davis, Kim, Li, Rhoads, Satterfield, Smith, Spencer, Yin (CR82) 2009; 37 Tsikas, Bollenbach, Hanff, Kayacelebi (CR71) 2018; 17 Sidney, Jacobs, Haskell, Armstrong, Dimicco, Oberman, Savage, Slattery, Sternfeld, Van Horn (CR64) 1991; 133 McCreight, Bailey, Pearson (CR48) 2016; 59 Stockebrand, Hornig, Neu, Atzler, Cordts, Böger, Isbrandt, Schwedhelm, Choe (CR66) 2015; 47 Schneider, Rothmann, Schröder, Langen, Lücke, Mariotti, Huneau, Frölich, Tsikas (CR61) 2015; 47 Tsikas, Wu (CR70) 2015; 47 Brosnan, Brosnan (CR8) 2007; 27 Kong, Tan, Yin, Gao, Li, Jaeger, Bazer, Wu (CR40) 2012; 23 Kayacelebi, Langen, Weigt-Usinger, Chobanyan-Jürgens, Mariotti, Schneider, Rothmann, Frölich, Atzler, Choe, Schwedhelm, Huneau, Lücke, Tsikas (CR38) 2015; 47 Wu (CR74) 1995; 312 Paddon-Jones, Borsheim, Wolfe (CR56) 2004; 134 Wu, Haynes, Li, Meininger (CR79) 2000; 126 Fu, Haynes, Kohli, Hu, Shi, Spencer, Carroll, Meininger, Wu (CR20) 2005; 135 Urbina, Roberts, Kephart, Villa, Santos, Olivencia, Bennett, Lara, Foster, Purpura, Jäger, Taylor, Wilborn (CR73) 2017; 113 Morris (CR54) 2007; 137 Hou, Jia, Nawaratna, Hu, Dahanayaka, Bazer, Wu (CR30) 2015; 47 Muñoz-Garach, Cornejo-Pareja, Tinahones (CR55) 2017; 8 McKnight, Satterfield, Jobgen, Smith, Spencer, Meininger, McNeal, Wu (CR49) 2010; 39 Lucotti, Setola, Monti, Galluccio, Costa, Sandoli, Fermo, Rabaiotti, Gatti, Piatti (CR44) 2006; 291 Wu, Meininger (CR77) 2008; 440 Clarkson, Adams, Powe, Donald, McCredie, Robinson, McCarthy, Keech, Celermajer, Deanfiled (CR12) 1996; 97 McNeal, Meininger, Reddy, Wilborn, Wu (CR51) 2016; 146 Sase, Nawaratna, Hu, Wu, Lubec (CR60) 2016; 48 Schulman, Becker, Kass, Champion, Terrin, Forman, Ernst, Kelemen, Townsend, Capriotti, Hare, Gernstenblith (CR62) 2006; 295 Papageorgiou, Androulakis, Papaioannou, Antoniades, Tousoulis (CR58) 2015; 47 Gornik, Creager (CR21) 2004; 134 Chin-Dusting, Alexander, Arnold, Hodgson, Lux, Jennings (CR11) 1996; 28 (CR27) 2006 Beaumier, Castillo, Ajami, Young (CR2) 1995; 269 Wu, Morris (CR78) 1998; 336 McNeal, Wu, Vasquez, Wilson, Satterfield, McKnight, Malbari, Bagchi (CR50) 2010 Bernstein, Jäger, Dobrowolny, Steiner, Keilhoff, Bogerts, Laube (CR3) 2015; 47 Tsubuku, Hatayama, Mawatari, Smriga, Kimura (CR72) 2004; 23 Wu, Meininger (CR76) 2000; 130 Marliss, Chevalier, Gougeon, Morais, Lamarche, Adegoke, Wu (CR47) 2006; 49 Hurt, Ebbert, Schroeder, Croghan, Bauer, McClave, Miles, McClain (CR34) 2014; 11 Jobgen, Fu, Gao, Li, Meininger, Smith, Spencer, Wu (CR37) 2009; 37 Evans, Fernstrom, Thompson, Morris, Kuller (CR17) 2004; 15 Colgan (CR14) 1993 Cynober (CR16) 2007; 137 Zheng, Liu, Wang, Zhou, Liu, Pan, Zhang, Zhu (CR86) 2016; 8 Grasemann, Grasemann, Kurtz, Tietze-Schillings, Vester, Ratjen (CR22) 2005; 25 Creager, Gallagher, Girerd, Coleman, Dzau, Cooke (CR15) 1992; 90 CR25 Mertens, Van Gaal (CR53) 2000; 8 Tan, Li, Kong, Huang, Ruan, Yao, Deng, Xie, Shinzato, Yin, Wu (CR67) 2009; 37 Wu, Hou, Hu, Bazer, Meininger, McNeal, Wu (CR83) 2016; 48 Hou, Yin, Wu (CR29) 2015; 240 Pilz, Meinitzer, Gaksch, Grübler, Verheyen, Drechsler, Hartaigh, Lang, Alesutan, Voelkl, März, Tomaschitz (CR59) 2015; 47 Tanghao, Chalon, Moreno, Hoffman, Blaschke (CR69) 1999; 96 Liao, Regmi, Wu (CR43) 2018; 23 Boger, Bode-Boger (CR7) 2001; 41 Castillo, Chapman, Yu, Ajami, Burke, Young (CR10) 1993; 265 Wu (CR75) 2013 Tan, Yin, Kong, Li, Li, Gao, Li, Huang, Wu (CR68) 2010; 38 Blachier, Leclercq-Meyer, Marchand, Woussen-Colle, Mathias, Sener, Malaisse (CR4) 1989; 1013 Hayashi (CR26) 2003; 133 Closs, Simon, Vékony, Rotmann (CR13) 2004; 134 Yao, Yin, Chu, Liu, Deng, Li, Huang, Zhang, Tan, Wang, Wu (CR85) 2008; 138 (CR18) 2006 Kayacelebi, Minović, Hanff, Frenay, de Borst, Feelisch, van Goor, Bakker, Tsikas (CR39) 2017; 49 X Ma (2594_CR46) 2017; 49 P Lucotti (2594_CR44) 2006; 291 WJ Jobgen (2594_CR36) 2009; 139 D Tsikas (2594_CR70) 2015; 47 B Jani (2594_CR35) 2006; 20 S Sidney (2594_CR64) 1991; 133 A Barbul (2594_CR1) 1986; 10 BE Tan (2594_CR67) 2009; 37 AJ Meijer (2594_CR52) 1985; 148 C McNeal (2594_CR50) 2010 JR McKnight (2594_CR49) 2010; 39 EB Marliss (2594_CR47) 2006; 49 M Stockebrand (2594_CR66) 2015; 47 Health Canada (2594_CR27) 2006 G Wu (2594_CR79) 2000; 126 Y Hayashi (2594_CR26) 2003; 133 A Muñoz-Garach (2594_CR55) 2017; 8 AA Kayacelebi (2594_CR39) 2017; 49 YQ Hou (2594_CR29) 2015; 240 K Yao (2594_CR85) 2008; 138 IL Mertens (2594_CR53) 2000; 8 O Tanghao (2594_CR69) 1999; 96 2594_CR25 AL Buchman (2594_CR9) 1999; 20 G Wu (2594_CR74) 1995; 312 G Wu (2594_CR78) 1998; 336 P Clarkson (2594_CR12) 1996; 97 L Cynober (2594_CR16) 2007; 137 N Papageorgiou (2594_CR58) 2015; 47 YC Luiking (2594_CR45) 2012; 303 G Wu (2594_CR82) 2009; 37 A Shao (2594_CR63) 2008; 50 HG Bernstein (2594_CR3) 2015; 47 LJ McCreight (2594_CR48) 2016; 59 SM Morris Jr (2594_CR54) 2007; 137 RH Boger (2594_CR7) 2001; 41 MA Creager (2594_CR15) 1992; 90 FAO/WHO (Food and Agriculture Organization/World Health Organization) (2594_CR18) 2006 A Haghikia (2594_CR24) 2017; 49 H Li (2594_CR41) 2000; 746 G Wu (2594_CR75) 2013 WJ Fu (2594_CR20) 2005; 135 YQ Hou (2594_CR28) 2017; 8 SL Urbina (2594_CR73) 2017; 113 AA Kayacelebi (2594_CR38) 2015; 47 BE Tan (2594_CR68) 2010; 38 JT Brosnan (2594_CR8) 2007; 27 L Castillo (2594_CR10) 1993; 265 M Colgan (2594_CR14) 1993 N Pahlavani (2594_CR57) 2017; 71 SD Hu (2594_CR33) 2015; 47 A Sase (2594_CR60) 2016; 48 S Pilz (2594_CR59) 2015; 47 CJ McNeal (2594_CR51) 2016; 146 W Jobgen (2594_CR37) 2009; 37 SP Schulman (2594_CR62) 2006; 295 F Blachier (2594_CR4) 1989; 1013 Y Yang (2594_CR84) 2015; 47 R Zheng (2594_CR86) 2016; 8 G Block (2594_CR6) 1992; 92 X Kong (2594_CR40) 2012; 23 H Li (2594_CR42) 2016; 48 D Tsikas (2594_CR71) 2018; 17 RW Evans (2594_CR17) 2004; 15 G Wu (2594_CR80) 2007; 137 JP Chin-Dusting (2594_CR11) 1996; 28 Y Hou (2594_CR32) 2016; 48 RT Hurt (2594_CR34) 2014; 11 HL Gornik (2594_CR21) 2004; 134 GK Grimble (2594_CR23) 2007; 137 YQ Hou (2594_CR31) 2016; 7 G Wu (2594_CR77) 2008; 440 NE Flynn (2594_CR19) 2002; 56 H Grasemann (2594_CR22) 2005; 25 G Wu (2594_CR81) 2007; 137 Y Hou (2594_CR30) 2015; 47 S Tsubuku (2594_CR72) 2004; 23 L Beaumier (2594_CR2) 1995; 269 F Blachier (2594_CR5) 2011; 16 N Stefan (2594_CR65) 2013; 1 G Wu (2594_CR76) 2000; 130 EI Closs (2594_CR13) 2004; 134 JY Schneider (2594_CR61) 2015; 47 SF Liao (2594_CR43) 2018; 23 D Paddon-Jones (2594_CR56) 2004; 134 ZL Wu (2594_CR83) 2016; 48 |
| References_xml | – year: 2006 ident: CR18 publication-title: A model for establishing upper levels of intake for nutrients and related substances – volume: 746 start-page: 199 year: 2000 end-page: 207 ident: CR41 article-title: Rapid determination of nitrite by reversed-phase high-performance liquid chromatography with fluorescence detection publication-title: J Chromatogr B doi: 10.1016/S0378-4347(00)00328-5 – volume: 303 start-page: E1177 year: 2012 end-page: E1189 ident: CR45 article-title: Arginine de novo and nitric oxide production in disease states publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00284.2012 – volume: 8 start-page: 270 year: 2000 end-page: 278 ident: CR53 article-title: Overweight, obesity, and blood pressure: the effects of modest weight reduction publication-title: Obes Res doi: 10.1038/oby.2000.32 – volume: 50 start-page: 376 year: 2008 end-page: 399 ident: CR63 article-title: Risk assessment for the amino acids taurine, -glutamine and -arginine publication-title: Regul Toxicol Pharmacol doi: 10.1016/j.yrtph.2008.01.004 – volume: 25 start-page: 62 year: 2005 end-page: 68 ident: CR22 article-title: Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study publication-title: Eur Respir J doi: 10.1183/09031936.04.00086104 – volume: 291 start-page: E906 year: 2006 end-page: E912 ident: CR44 article-title: Beneficial effect of a long-term oral -arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00002.2006 – volume: 48 start-page: 2401 year: 2016 end-page: 2410 ident: CR42 article-title: Intracellular sources of ornithine for polyamine synthesis in endothelial cells publication-title: Amino Acids doi: 10.1007/s00726-016-2256-6 – volume: 96 start-page: 199 year: 1999 end-page: 207 ident: CR69 article-title: Pharmacokinetics of -arginine during chronic administration to patients with hypercholesterolaemia publication-title: Clin Sci (Lond) doi: 10.1042/cs0960199 – volume: 137 start-page: 2680 year: 2007 end-page: 2685 ident: CR81 article-title: Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats publication-title: J Nutr doi: 10.1093/jn/137.12.2680 – volume: 47 start-page: 925 year: 2015 end-page: 936 ident: CR33 article-title: Safety of long-term dietary supplementation with -arginine in pigs publication-title: Amino Acids doi: 10.1007/s00726-015-1921-5 – volume: 47 start-page: 1893 year: 2015 end-page: 1908 ident: CR38 article-title: Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free -arginine in humans publication-title: Amino Acids doi: 10.1007/s00726-015-2012-3 – volume: 38 start-page: 1227 year: 2010 end-page: 1235 ident: CR68 article-title: -Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells publication-title: Amino Acids doi: 10.1007/s00726-009-0334-8 – ident: CR25 – volume: 20 start-page: 543 year: 2006 end-page: 545 ident: CR35 article-title: Blood pressure measurement in patients with rate controlled atrial fibrillation using mercury sphygmomanometer and Omron HEM-750CP deice in the clinic setting publication-title: J Hum Hypert doi: 10.1038/sj.jhh.1002016 – volume: 16 start-page: 1331 year: 2011 end-page: 1343 ident: CR5 article-title: Channelling of arginine in NO and polyamine pathways in colonocytes and consequences publication-title: Front Biosci doi: 10.2741/3792 – volume: 47 start-page: 1961 year: 2015 end-page: 1974 ident: CR61 article-title: Effects of chronic oral -arginine administration on the -arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: -Arginine prevents renal loss of nitrite, the major NO reservoir publication-title: Amino Acids doi: 10.1007/s00726-015-2031-0 – year: 1993 ident: CR14 publication-title: Optimum sports nutrition: your competitive edge – volume: 295 start-page: 58 year: 2006 end-page: 64 ident: CR62 article-title: L-Arginine therapy in acute myocardial infarction: the vascular interaction with age in myocardial infarction (VINTAGE) randomized clinical trial publication-title: JAMA doi: 10.1001/jama.295.1.58 – volume: 269 start-page: E884 year: 1995 end-page: E896 ident: CR2 article-title: Urea cycle intermediate kinetics and nitrate excretion at normal and “therapeutic” intakes of arginine in humans publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.1995.269.5.E884 – volume: 240 start-page: 997 year: 2015 end-page: 1007 ident: CR29 article-title: Dietary essentiality of “nutritionally nonessential amino acids” for animals and humans publication-title: Exp Biol Med doi: 10.1177/1535370215587913 – volume: 138 start-page: 867 year: 2008 end-page: 872 ident: CR85 article-title: Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs publication-title: J Nutr doi: 10.1093/jn/138.5.867 – volume: 148 start-page: 189 year: 1985 end-page: 196 ident: CR52 article-title: Control of ureogenesis publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1985.tb08824.x – volume: 90 start-page: 1248 year: 1992 end-page: 1253 ident: CR15 article-title: -Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans publication-title: J Clin Invest doi: 10.1172/JCI115987 – volume: 135 start-page: 714 year: 2005 end-page: 721 ident: CR20 article-title: Dietary -arginine supplementation reduces fat mass in Zucker diabetic fatty rats publication-title: J Nutr doi: 10.1093/jn/135.4.714 – volume: 47 start-page: 2005 year: 2015 end-page: 2014 ident: CR30 article-title: Analysis of -homoarginine in biological samples by HPLC involving precolumn derivatization with -phthalaldehyde and -acetyl- -cysteine publication-title: Amino Acids doi: 10.1007/s00726-015-1962-9 – volume: 8 start-page: 320 year: 2017 ident: CR55 article-title: Does metabolically healthy obesity exist? publication-title: Nutrients doi: 10.3390/nu8060320 – volume: 440 start-page: 177 year: 2008 end-page: 189 ident: CR77 article-title: Analysis of citrulline, arginine, and methylarginines using high-performance liquid chromatography publication-title: Methods Enzymol doi: 10.1016/S0076-6879(07)00810-5 – year: 2006 ident: CR27 publication-title: Canadian adverse drug reaction monitoring program – year: 2013 ident: CR75 publication-title: Amino acids: biochemistry and nutrition doi: 10.1201/b14661 – volume: 137 start-page: 1646S year: 2007 end-page: 1649S ident: CR16 article-title: Pharmacokinetics of arginine and related amino acids publication-title: J Nutr doi: 10.1093/jn/137.6.1646S – volume: 47 start-page: 1921 year: 2015 end-page: 1929 ident: CR66 article-title: Homoarginine supplementation improves blood glucose in diet-induced obese mice publication-title: Amino Acids doi: 10.1007/s00726-015-2022-1 – volume: 48 start-page: 993 year: 2016 end-page: 1001 ident: CR32 article-title: Whole-body synthesis of L-homoarginine in pigs and rats supplemented with -arginine publication-title: Amino Acids doi: 10.1007/s00726-015-2145-4 – volume: 47 start-page: 1697 year: 2015 end-page: 1702 ident: CR70 article-title: Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology publication-title: Amino Acids doi: 10.1007/s00726-015-2055-5 – volume: 8 start-page: 137 year: 2017 end-page: 139 ident: CR28 article-title: Nutritionally nonessential amino acids: a misnomer in nutritional sciences publication-title: Adv Nutr doi: 10.3945/an.116.012971 – volume: 49 start-page: 957 year: 2017 end-page: 964 ident: CR46 article-title: -Arginine promotes protein synthesis and cell growth in brown adipocyte precursor cells via the mTOR signal pathway publication-title: Amino Acids doi: 10.1007/s00726-017-2399-0 – volume: 146 start-page: 2587S year: 2016 end-page: 2593S ident: CR51 article-title: Safety and effectiveness of arginine in adults publication-title: J Nutr doi: 10.3945/jn.116.234740 – volume: 10 start-page: 227 year: 1986 end-page: 238 ident: CR1 article-title: Arginine: biochemistry, physiology, and therapeutic implications publication-title: J Parenter Enteral Nutr doi: 10.1177/0148607186010002227 – volume: 312 start-page: 717 year: 1995 end-page: 723 ident: CR74 article-title: Urea synthesis in enterocytes of developing pigs publication-title: Biochem J doi: 10.1042/bj3120717 – volume: 20 start-page: 315 year: 1999 end-page: 321 ident: CR9 article-title: The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run publication-title: Int J Sports Med doi: 10.1055/s-2007-971137 – volume: 39 start-page: 349 year: 2010 end-page: 357 ident: CR49 article-title: Beneficial effects of -arginine on reducing obesity: potential mechanisms and important implications for human health publication-title: Amino Acids doi: 10.1007/s00726-010-0598-z – volume: 133 start-page: 1231 year: 1991 end-page: 1245 ident: CR64 article-title: Comparison of two methods of assessing physical activity in the coronary artery risk development in young adults (CARDIA) Study publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a115835 – volume: 49 start-page: 1193 year: 2017 end-page: 1202 ident: CR39 article-title: Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients publication-title: Amino Acids doi: 10.1007/s00726-017-2420-7 – volume: 71 start-page: 544 year: 2017 end-page: 548 ident: CR57 article-title: The effect of -arginine supplementation on body composition and performance in male athletes: a double-blinded randomized clinical trial publication-title: Eur J Clin Nutr doi: 10.1038/ejcn.2016.266 – volume: 47 start-page: 1741 year: 2015 end-page: 1750 ident: CR58 article-title: Homoarginine in the shadow of asymmetric dimethylarginine: from nitric oxide to cardiovascular disease publication-title: Amino Acids doi: 10.1007/s00726-015-2017-y – volume: 47 start-page: 1907 year: 2015 end-page: 1920 ident: CR84 article-title: Safety of long-term dietary supplementation with -arginine in rats publication-title: Amino Acids – volume: 17 start-page: 1 issue: 1 year: 2018 ident: CR71 article-title: Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0656-x – volume: 41 start-page: 79 year: 2001 end-page: 99 ident: CR7 article-title: The clinical pharmacology of -arginine publication-title: Annu Rev Pharmacol Toxicol doi: 10.1146/annurev.pharmtox.41.1.79 – volume: 134 start-page: 2880S year: 2004 end-page: 2887S ident: CR21 article-title: Arginine and endothelial and vascular health publication-title: J Nutr doi: 10.1093/jn/134.10.2880S – volume: 27 start-page: 241 year: 2007 end-page: 261 ident: CR8 article-title: Creatine: endogenous metabolite, dietary, and therapeutic supplement publication-title: Annu Rev Nutr doi: 10.1146/annurev.nutr.27.061406.093621 – volume: 134 start-page: 2752S year: 2004 end-page: 2759S ident: CR13 article-title: Plasma membrane transporters for arginine publication-title: J Nutr doi: 10.1093/jn/134.10.2752S – volume: 126 start-page: 115 year: 2000 end-page: 123 ident: CR79 article-title: Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase publication-title: Comp Biochem Physiol A doi: 10.1016/S1095-6433(00)00196-3 – volume: 139 start-page: 230 year: 2009 end-page: 237 ident: CR36 article-title: Dietary -arginine supplementation reduces white-fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats publication-title: J Nutr doi: 10.3945/jn.108.096362 – volume: 37 start-page: 323 year: 2009 end-page: 331 ident: CR67 article-title: Dietary -arginine supplementation enhances the immune status in early-weaned piglets publication-title: Amino Acids doi: 10.1007/s00726-008-0155-1 – volume: 15 start-page: 534 year: 2004 end-page: 539 ident: CR17 article-title: Biochemical responses of healthy subjects during dietary supplementation with -arginine publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2004.03.005 – volume: 23 start-page: 640 year: 2018 end-page: 655 ident: CR43 article-title: Homeostatic regulation of plasma amino acid concentrations publication-title: Front Biosci doi: 10.2741/4610 – volume: 134 start-page: 2888S year: 2004 end-page: 2894S ident: CR56 article-title: Potential ergogenic effects of arginine and creatine supplementation publication-title: J Nutr doi: 10.1093/jn/134.10.2888S – volume: 47 start-page: 1729 year: 2015 end-page: 1740 ident: CR3 article-title: Possible sources and functions of -homoarginine in the brain: review of the literature and own findings publication-title: Amino Acids doi: 10.1007/s00726-015-1960-y – volume: 47 start-page: 1703 year: 2015 end-page: 1713 ident: CR59 article-title: Homoarginine in the renal and cardiovascular systems publication-title: Amino Acids doi: 10.1007/s00726-015-1993-2 – volume: 113 start-page: 264 year: 2017 end-page: 273 ident: CR73 article-title: Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals publication-title: Appetite doi: 10.1016/j.appet.2017.02.025 – volume: 37 start-page: 187 year: 2009 end-page: 198 ident: CR37 article-title: High fat feeding and dietary -arginine supplementation differentially regulate gene expression in rat white adipose tissue publication-title: Amino Acids doi: 10.1007/s00726-009-0246-7 – volume: 28 start-page: 158 year: 1996 end-page: 166 ident: CR11 article-title: Effects of in vivo and in vitro -arginine supplementation on healthy human vessels publication-title: J Cardiovasc Pharmacol doi: 10.1097/00005344-199607000-00023 – volume: 48 start-page: 1541 year: 2016 end-page: 1552 ident: CR83 article-title: Catabolism and safety of supplemental -arginine in animals publication-title: Amino Acids doi: 10.1007/s00726-016-2245-9 – volume: 137 start-page: 1673S year: 2007 end-page: 1680S ident: CR80 article-title: Pharmacokinetics and safety of arginine supplementation in animals publication-title: J Nutr doi: 10.1093/jn/137.6.1673S – volume: 49 start-page: 351 year: 2006 end-page: 359 ident: CR47 article-title: Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover publication-title: Diabetologia doi: 10.1007/s00125-005-0066-6 – start-page: 433 year: 2010 end-page: 442 ident: CR50 article-title: The role of arginine for treating obese youth publication-title: Global perspectives on childhood obesity – volume: 1 start-page: 152 year: 2013 end-page: 162 ident: CR65 article-title: Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(13)70062-7 – volume: 137 start-page: 1693S year: 2007 end-page: 1701S ident: CR23 article-title: Advanced gastrointestinal effects of arginine and related amino acids publication-title: J Nutr doi: 10.1093/jn/137.6.1693S – volume: 56 start-page: 427 year: 2002 end-page: 438 ident: CR19 article-title: The metabolic basis of arginine nutrition and pharmacotherapy publication-title: Biomed Pharmacother doi: 10.1016/S0753-3322(02)00273-1 – volume: 37 start-page: 153 year: 2009 end-page: 168 ident: CR82 article-title: Arginine metabolism and nutrition in growth, health and disease publication-title: Amino Acids doi: 10.1007/s00726-008-0210-y – volume: 23 start-page: 1178 year: 2012 end-page: 1183 ident: CR40 article-title: -Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2011.06.012 – volume: 97 start-page: 1989 year: 1996 end-page: 1994 ident: CR12 article-title: Oral -arginine improves endothelium-dependent dilation in hypercholesterolemic young adults publication-title: J Clin Invest doi: 10.1172/JCI118632 – volume: 130 start-page: 2626 year: 2000 end-page: 2629 ident: CR76 article-title: Arginine nutrition and cardiovascular function publication-title: J Nutr doi: 10.1093/jn/130.11.2626 – volume: 133 start-page: 2021S year: 2003 end-page: 2024S ident: CR26 article-title: Application of the concept of risk assessment to the study of amino acid supplements publication-title: J Nutr doi: 10.1093/jn/133.6.2021S – volume: 336 start-page: 1 year: 1998 end-page: 17 ident: CR78 article-title: Arginine metabolism: nitric oxide and beyond publication-title: Biochem J doi: 10.1042/bj3360001 – volume: 137 start-page: 1602S year: 2007 end-page: 1609S ident: CR54 article-title: Arginine metabolism: boundaries of our knowledge publication-title: J Nutr doi: 10.1093/jn/137.6.1602S – volume: 8 start-page: 430 year: 2016 ident: CR86 article-title: Natural course of metabolically healthy overweight/obese subjects and the impact of weight change publication-title: Nutrients doi: 10.3390/nu8070430 – volume: 59 start-page: 426 year: 2016 end-page: 435 ident: CR48 article-title: Metformin and the gastrointestinal tract publication-title: Diabetologia doi: 10.1007/s00125-015-3844-9 – volume: 265 start-page: E532 year: 1993 end-page: E539 ident: CR10 article-title: Dietary arginine uptake by the splanchnic region in adult humans publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.1993.265.4.E532 – volume: 23 start-page: 101 year: 2004 end-page: 105 ident: CR72 article-title: Thirteen-week oral toxicity study of -arginine in rats publication-title: Int J Toxicol doi: 10.1080/10915810490435622 – volume: 48 start-page: 2197 year: 2016 end-page: 2204 ident: CR60 article-title: Decreased hippocampal homoarginine and increased nitric oxide and nitric oxide synthase levels in rats parallel training in a radial arm maze publication-title: Amino Acids doi: 10.1007/s00726-016-2251-y – volume: 92 start-page: 686 year: 1992 end-page: 693 ident: CR6 article-title: Comparison of two dietary questionnaires validated against multiple dietary records collected during a 1-year period publication-title: J Am Diet Assoc – volume: 49 start-page: 1111 year: 2017 end-page: 1121 ident: CR24 article-title: The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients publication-title: Amino Acids doi: 10.1007/s00726-017-2409-2 – volume: 1013 start-page: 144 year: 1989 end-page: 151 ident: CR4 article-title: Stimulus-secretion coupling of arginine-induced insulin release. Functional response of islets to -arginine and L-ornithine publication-title: Biochim Biophys Acta doi: 10.1016/0167-4889(89)90042-6 – volume: 7 start-page: 331 year: 2016 end-page: 342 ident: CR31 article-title: Endogenous synthesis of amino acids limits growth, lactation and reproduction of animals publication-title: Adv Nutr doi: 10.3945/an.115.010850 – volume: 11 start-page: 40 year: 2014 end-page: 52 ident: CR34 article-title: -arginine for the treatment of centrally obese subjects: a pilot study publication-title: J Diet Suppl doi: 10.3109/19390211.2013.859216 – volume: 295 start-page: 58 year: 2006 ident: 2594_CR62 publication-title: JAMA doi: 10.1001/jama.295.1.58 – volume: 49 start-page: 1111 year: 2017 ident: 2594_CR24 publication-title: Amino Acids doi: 10.1007/s00726-017-2409-2 – volume: 113 start-page: 264 year: 2017 ident: 2594_CR73 publication-title: Appetite doi: 10.1016/j.appet.2017.02.025 – volume: 38 start-page: 1227 year: 2010 ident: 2594_CR68 publication-title: Amino Acids doi: 10.1007/s00726-009-0334-8 – volume: 47 start-page: 1893 year: 2015 ident: 2594_CR38 publication-title: Amino Acids doi: 10.1007/s00726-015-2012-3 – volume: 48 start-page: 1541 year: 2016 ident: 2594_CR83 publication-title: Amino Acids doi: 10.1007/s00726-016-2245-9 – volume: 23 start-page: 101 year: 2004 ident: 2594_CR72 publication-title: Int J Toxicol doi: 10.1080/10915810490435622 – volume: 1 start-page: 152 year: 2013 ident: 2594_CR65 publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(13)70062-7 – volume-title: Optimum sports nutrition: your competitive edge year: 1993 ident: 2594_CR14 – volume: 134 start-page: 2752S year: 2004 ident: 2594_CR13 publication-title: J Nutr doi: 10.1093/jn/134.10.2752S – volume: 48 start-page: 2401 year: 2016 ident: 2594_CR42 publication-title: Amino Acids doi: 10.1007/s00726-016-2256-6 – volume: 133 start-page: 2021S year: 2003 ident: 2594_CR26 publication-title: J Nutr doi: 10.1093/jn/133.6.2021S – start-page: 433 volume-title: Global perspectives on childhood obesity year: 2010 ident: 2594_CR50 – volume: 291 start-page: E906 year: 2006 ident: 2594_CR44 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00002.2006 – volume: 137 start-page: 1673S year: 2007 ident: 2594_CR80 publication-title: J Nutr doi: 10.1093/jn/137.6.1673S – volume: 269 start-page: E884 year: 1995 ident: 2594_CR2 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.1995.269.5.E884 – volume: 20 start-page: 315 year: 1999 ident: 2594_CR9 publication-title: Int J Sports Med doi: 10.1055/s-2007-971137 – volume: 139 start-page: 230 year: 2009 ident: 2594_CR36 publication-title: J Nutr doi: 10.3945/jn.108.096362 – volume: 8 start-page: 270 year: 2000 ident: 2594_CR53 publication-title: Obes Res doi: 10.1038/oby.2000.32 – volume: 48 start-page: 2197 year: 2016 ident: 2594_CR60 publication-title: Amino Acids doi: 10.1007/s00726-016-2251-y – volume: 10 start-page: 227 year: 1986 ident: 2594_CR1 publication-title: J Parenter Enteral Nutr doi: 10.1177/0148607186010002227 – volume: 47 start-page: 1697 year: 2015 ident: 2594_CR70 publication-title: Amino Acids doi: 10.1007/s00726-015-2055-5 – volume: 37 start-page: 187 year: 2009 ident: 2594_CR37 publication-title: Amino Acids doi: 10.1007/s00726-009-0246-7 – volume: 97 start-page: 1989 year: 1996 ident: 2594_CR12 publication-title: J Clin Invest doi: 10.1172/JCI118632 – volume-title: Canadian adverse drug reaction monitoring program year: 2006 ident: 2594_CR27 – volume: 49 start-page: 351 year: 2006 ident: 2594_CR47 publication-title: Diabetologia doi: 10.1007/s00125-005-0066-6 – volume: 59 start-page: 426 year: 2016 ident: 2594_CR48 publication-title: Diabetologia doi: 10.1007/s00125-015-3844-9 – volume: 41 start-page: 79 year: 2001 ident: 2594_CR7 publication-title: Annu Rev Pharmacol Toxicol doi: 10.1146/annurev.pharmtox.41.1.79 – volume: 27 start-page: 241 year: 2007 ident: 2594_CR8 publication-title: Annu Rev Nutr doi: 10.1146/annurev.nutr.27.061406.093621 – volume: 17 start-page: 1 issue: 1 year: 2018 ident: 2594_CR71 publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-017-0656-x – volume-title: A model for establishing upper levels of intake for nutrients and related substances year: 2006 ident: 2594_CR18 – volume: 23 start-page: 1178 year: 2012 ident: 2594_CR40 publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2011.06.012 – volume: 126 start-page: 115 year: 2000 ident: 2594_CR79 publication-title: Comp Biochem Physiol A doi: 10.1016/S1095-6433(00)00196-3 – volume: 25 start-page: 62 year: 2005 ident: 2594_CR22 publication-title: Eur Respir J doi: 10.1183/09031936.04.00086104 – volume: 8 start-page: 320 year: 2017 ident: 2594_CR55 publication-title: Nutrients doi: 10.3390/nu8060320 – volume: 303 start-page: E1177 year: 2012 ident: 2594_CR45 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00284.2012 – volume: 1013 start-page: 144 year: 1989 ident: 2594_CR4 publication-title: Biochim Biophys Acta doi: 10.1016/0167-4889(89)90042-6 – volume: 148 start-page: 189 year: 1985 ident: 2594_CR52 publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1985.tb08824.x – volume: 746 start-page: 199 year: 2000 ident: 2594_CR41 publication-title: J Chromatogr B doi: 10.1016/S0378-4347(00)00328-5 – volume: 39 start-page: 349 year: 2010 ident: 2594_CR49 publication-title: Amino Acids doi: 10.1007/s00726-010-0598-z – volume: 71 start-page: 544 year: 2017 ident: 2594_CR57 publication-title: Eur J Clin Nutr doi: 10.1038/ejcn.2016.266 – volume: 240 start-page: 997 year: 2015 ident: 2594_CR29 publication-title: Exp Biol Med doi: 10.1177/1535370215587913 – volume: 96 start-page: 199 year: 1999 ident: 2594_CR69 publication-title: Clin Sci (Lond) doi: 10.1042/cs0960199 – volume: 137 start-page: 1646S year: 2007 ident: 2594_CR16 publication-title: J Nutr doi: 10.1093/jn/137.6.1646S – volume: 49 start-page: 1193 year: 2017 ident: 2594_CR39 publication-title: Amino Acids doi: 10.1007/s00726-017-2420-7 – volume: 49 start-page: 957 year: 2017 ident: 2594_CR46 publication-title: Amino Acids doi: 10.1007/s00726-017-2399-0 – volume: 130 start-page: 2626 year: 2000 ident: 2594_CR76 publication-title: J Nutr doi: 10.1093/jn/130.11.2626 – volume: 47 start-page: 1907 year: 2015 ident: 2594_CR84 publication-title: Amino Acids – volume: 92 start-page: 686 year: 1992 ident: 2594_CR6 publication-title: J Am Diet Assoc doi: 10.1016/S0002-8223(21)00707-0 – volume: 11 start-page: 40 year: 2014 ident: 2594_CR34 publication-title: J Diet Suppl doi: 10.3109/19390211.2013.859216 – volume: 138 start-page: 867 year: 2008 ident: 2594_CR85 publication-title: J Nutr doi: 10.1093/jn/138.5.867 – volume: 47 start-page: 1741 year: 2015 ident: 2594_CR58 publication-title: Amino Acids doi: 10.1007/s00726-015-2017-y – volume: 135 start-page: 714 year: 2005 ident: 2594_CR20 publication-title: J Nutr doi: 10.1093/jn/135.4.714 – volume: 265 start-page: E532 year: 1993 ident: 2594_CR10 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.1993.265.4.E532 – ident: 2594_CR25 – volume: 8 start-page: 137 year: 2017 ident: 2594_CR28 publication-title: Adv Nutr doi: 10.3945/an.116.012971 – volume: 90 start-page: 1248 year: 1992 ident: 2594_CR15 publication-title: J Clin Invest doi: 10.1172/JCI115987 – volume: 47 start-page: 2005 year: 2015 ident: 2594_CR30 publication-title: Amino Acids doi: 10.1007/s00726-015-1962-9 – volume: 47 start-page: 925 year: 2015 ident: 2594_CR33 publication-title: Amino Acids doi: 10.1007/s00726-015-1921-5 – volume: 37 start-page: 323 year: 2009 ident: 2594_CR67 publication-title: Amino Acids doi: 10.1007/s00726-008-0155-1 – volume: 47 start-page: 1961 year: 2015 ident: 2594_CR61 publication-title: Amino Acids doi: 10.1007/s00726-015-2031-0 – volume: 50 start-page: 376 year: 2008 ident: 2594_CR63 publication-title: Regul Toxicol Pharmacol doi: 10.1016/j.yrtph.2008.01.004 – volume: 16 start-page: 1331 year: 2011 ident: 2594_CR5 publication-title: Front Biosci doi: 10.2741/3792 – volume: 56 start-page: 427 year: 2002 ident: 2594_CR19 publication-title: Biomed Pharmacother doi: 10.1016/S0753-3322(02)00273-1 – volume: 8 start-page: 430 year: 2016 ident: 2594_CR86 publication-title: Nutrients doi: 10.3390/nu8070430 – volume: 7 start-page: 331 year: 2016 ident: 2594_CR31 publication-title: Adv Nutr doi: 10.3945/an.115.010850 – volume: 134 start-page: 2880S year: 2004 ident: 2594_CR21 publication-title: J Nutr doi: 10.1093/jn/134.10.2880S – volume: 134 start-page: 2888S year: 2004 ident: 2594_CR56 publication-title: J Nutr doi: 10.1093/jn/134.10.2888S – volume: 23 start-page: 640 year: 2018 ident: 2594_CR43 publication-title: Front Biosci doi: 10.2741/4610 – volume: 47 start-page: 1703 year: 2015 ident: 2594_CR59 publication-title: Amino Acids doi: 10.1007/s00726-015-1993-2 – volume: 28 start-page: 158 year: 1996 ident: 2594_CR11 publication-title: J Cardiovasc Pharmacol doi: 10.1097/00005344-199607000-00023 – volume: 312 start-page: 717 year: 1995 ident: 2594_CR74 publication-title: Biochem J doi: 10.1042/bj3120717 – volume: 133 start-page: 1231 year: 1991 ident: 2594_CR64 publication-title: Am J Epidemiol doi: 10.1093/oxfordjournals.aje.a115835 – volume: 37 start-page: 153 year: 2009 ident: 2594_CR82 publication-title: Amino Acids doi: 10.1007/s00726-008-0210-y – volume: 137 start-page: 1693S year: 2007 ident: 2594_CR23 publication-title: J Nutr doi: 10.1093/jn/137.6.1693S – volume: 47 start-page: 1921 year: 2015 ident: 2594_CR66 publication-title: Amino Acids doi: 10.1007/s00726-015-2022-1 – volume: 48 start-page: 993 year: 2016 ident: 2594_CR32 publication-title: Amino Acids doi: 10.1007/s00726-015-2145-4 – volume: 20 start-page: 543 year: 2006 ident: 2594_CR35 publication-title: J Hum Hypert doi: 10.1038/sj.jhh.1002016 – volume-title: Amino acids: biochemistry and nutrition year: 2013 ident: 2594_CR75 doi: 10.1201/b14661 – volume: 146 start-page: 2587S year: 2016 ident: 2594_CR51 publication-title: J Nutr doi: 10.3945/jn.116.234740 – volume: 15 start-page: 534 year: 2004 ident: 2594_CR17 publication-title: J Nutr Biochem doi: 10.1016/j.jnutbio.2004.03.005 – volume: 47 start-page: 1729 year: 2015 ident: 2594_CR3 publication-title: Amino Acids doi: 10.1007/s00726-015-1960-y – volume: 137 start-page: 1602S year: 2007 ident: 2594_CR54 publication-title: J Nutr doi: 10.1093/jn/137.6.1602S – volume: 137 start-page: 2680 year: 2007 ident: 2594_CR81 publication-title: J Nutr doi: 10.1093/jn/137.12.2680 – volume: 440 start-page: 177 year: 2008 ident: 2594_CR77 publication-title: Methods Enzymol doi: 10.1016/S0076-6879(07)00810-5 – volume: 336 start-page: 1 year: 1998 ident: 2594_CR78 publication-title: Biochem J doi: 10.1042/bj3360001 |
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-arginine (Arg) on reducing white fat and improving... Previous studies with animals and humans have shown beneficial effects of dietary supplementation with L-arginine (Arg) on reducing white fat and improving... Previous studies with animals and humans have shown beneficial effects of dietary supplementation with l-arginine (Arg) on reducing white fat and improving... |
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| Title | Safety of dietary supplementation with arginine in adult humans |
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