Regulation of Diabetes: a Therapeutic Strategy for Alzheimer's Disease?

• Published in: Journal of Korean medical science Vol. 34; no. 46; p. e297
• Main Authors: Ahn, Kee Chan, Learman, Cameron R, Baker, Glen B, Weaver, Charles L, Chung, Phil Sang, Kim, Hyung Gun, Song, Mee Sook
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 02.12.2019; 대한의학회
• Subjects: Alzheimer Disease - complications; Alzheimer Disease - drug therapy; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Astrocytes - cytology; Astrocytes - metabolism; Brain - metabolism; Cerebrovascular Disorders - complications; Cerebrovascular Disorders - pathology; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - pathology; Humans; Hypoglycemic Agents - therapeutic use; Lithium Chloride - therapeutic use; Pioglitazone - therapeutic use; Review; 의학일반; Insulin Signaling; Diabetes; Oxidative Stress; Alzheimer's Disease; Blood Brain Barrier; Brain Inflammation

Accumulated evidence suggests that sporadic cases of Alzheimer's disease (AD) make up more than 95% of total AD patients, and diabetes has been implicated as a strong risk factor for the development of AD. Diabetes shares pathological features of AD, such as impaired insulin signaling, increase...