Progressive selection for neurovirulent genotypes in the brain of SIV-infected macaques

• Published in: AIDS (London) Vol. 20; no. 2; pp. 197 - 205
• Main Authors: BABAS, Tahar, DEWITT, Jesse B, MANKOWSKI, Joseph L, TARWATER, Patrick M, CLEMENTS, Janice E, ZINK, M. Christine
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 09.01.2006
• Subjects: Acute Disease; AIDS/HIV; Animals; Biological and medical sciences; Brain - virology; DNA, Viral - analysis; Encephalitis, Viral - pathology; Encephalitis, Viral - virology; Genotype; Human viral diseases; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Leukocytes, Mononuclear - virology; Macaca; Macaca nemestrina; Medical sciences; RNA, Viral - analysis; RNA, Viral - blood; Selection, Genetic; Simian Acquired Immunodeficiency Syndrome - pathology; Simian Acquired Immunodeficiency Syndrome - virology; Simian immunodeficiency virus; Simian Immunodeficiency Virus - genetics; Simian Immunodeficiency Virus - isolation & purification; Simian Immunodeficiency Virus - pathogenicity; Simian Immunodeficiency Virus - physiology; Time Factors; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virulence - genetics; Virus Replication; Brain; SIV; Microbiological investigation; Primates; Immunopathology; Encephalitis; Nervous system diseases; Typing; Retroviridae; Genotype; AIDS; Immune deficiency; Lentivirus; Cerebral disorder; Virus; Infection; Progressive; Vertebrata; envelope; Mammalia; HIV; Viral disease; Central nervous system disease; Simian immunodeficiency virus; neurovirulent; Macrophage

To compare the viral genotypes present in RNA from brain and peripheral blood mononuclear cells (PBMC) and DNA from brain during acute, asymptomatic and late stages of SIV infection of macaques. Eighteen pigtailed macaques were intravenously inoculated with SIV. At 10, 21 and 56 days postinoculation...