COVID-19 Patients Upregulate Toll-like Receptor 4-mediated Inflammatory Signaling That Mimics Bacterial Sepsis

• Published in: Journal of Korean medical science Vol. 35; no. 38; pp. e343 - 17
• Main Authors: Sohn, Kyung Mok, Lee, Sung-Gwon, Kim, Hyeon Ji, Cheon, Shinhyea, Jeong, Hyeongseok, Lee, Jooyeon, Kim, In Soo, Silwal, Prashanta, Kim, Young Jae, Paik, Seungwha, Chung, Chaeuk, Park, Chungoo, Kim, Yeon-Sook, Jo, Eun-Kyeong
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 28.09.2020; 대한의학회
• Subjects: Adult; Aged; Aged, 80 and over; Bacteremia - etiology; Betacoronavirus; Coronavirus Infections - immunology; COVID-19; Diagnosis, Differential; Female; Humans; Inflammation - etiology; Male; Middle Aged; Original; Pandemics; Pneumonia, Viral - immunology; SARS-CoV-2; Sepsis - etiology; Signal Transduction - physiology; Toll-Like Receptor 4 - physiology; Up-Regulation; 의학일반; SARS-CoV-2; Inflammation; Cytokines; S100A9

Observational studies of the ongoing coronavirus disease 2019 (COVID-19) outbreak suggest that a 'cytokine storm' is involved in the pathogenesis of severe illness. However, the molecular mechanisms underlying the altered pathological inflammation in COVID-19 are largely unknown. We report...