Efficacy of Oral Appliance Therapy as a First-Line Treatment for Moderate or Severe Obstructive Sleep Apnea: A Korean Prospective Multicenter Observational Study
Responses to oral appliances (OAs) in obstructive sleep apnea (OSA) vary, and have not been fully evaluated in Korean patients. In this study we aimed to determine the efficacy of OAs for the first-line treatment of Korean patients with moderate or severe OSA. This multicenter prospective observatio...
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| Published in | Journal of clinical neurology (Seoul, Korea) Vol. 16; no. 2; pp. 215 - 221 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Neurological Association
01.04.2020
대한신경과학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1738-6586 2005-5013 |
| DOI | 10.3988/jcn.2020.16.2.215 |
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| Abstract | Responses to oral appliances (OAs) in obstructive sleep apnea (OSA) vary, and have not been fully evaluated in Korean patients. In this study we aimed to determine the efficacy of OAs for the first-line treatment of Korean patients with moderate or severe OSA.
This multicenter prospective observational study included 45 patients with moderate or severe OSA that had been newly diagnosed between March 2017 and May 2018 and who underwent OA treatment for 1 month. Questionnaires were completed and polysomnography (PSG) was performed before and after OA treatment. The primary outcome measures were improvement in the absolute apnea-hypopnea index (AHI) and the percentage reduction in the AHI. The secondary outcomes were improvements in the questionnaire scores related to sleep-associated symptoms and PSG parameters.
The patients were aged 47.4±12.1 years (mean±SD), only two of them were female, and their AHI at baseline was 29.7±10.9/h. After OA treatment the AHI had reduced by 63.9±25.8%, with the reduction was similar between the patients with moderate OSA and those with severe OSA. Overall 31.1% of the patients achieved a normal AHI (<5/h), and 64.4% had an AHI of ≤10/h after the treatment. The body mass index (BMI) was the most reliable factor for predicting the percentage reduction in the AHI. The OAs also improved the sleep architecture and subjective sleep-related symptoms.
The OAs were effective in patients with moderate or severe OSA. The OAs reduced the mean AHI to 63.9% of the baseline value, and this reduction was influenced by the BMI. |
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| AbstractList | Responses to oral appliances (OAs) in obstructive sleep apnea (OSA) vary, and have not been fully evaluated in Korean patients. In this study we aimed to determine the efficacy of OAs for the first-line treatment of Korean patients with moderate or severe OSA.
This multicenter prospective observational study included 45 patients with moderate or severe OSA that had been newly diagnosed between March 2017 and May 2018 and who underwent OA treatment for 1 month. Questionnaires were completed and polysomnography (PSG) was performed before and after OA treatment. The primary outcome measures were improvement in the absolute apnea-hypopnea index (AHI) and the percentage reduction in the AHI. The secondary outcomes were improvements in the questionnaire scores related to sleep-associated symptoms and PSG parameters.
The patients were aged 47.4±12.1 years (mean±SD), only two of them were female, and their AHI at baseline was 29.7±10.9/h. After OA treatment the AHI had reduced by 63.9±25.8%, with the reduction was similar between the patients with moderate OSA and those with severe OSA. Overall 31.1% of the patients achieved a normal AHI (<5/h), and 64.4% had an AHI of ≤10/h after the treatment. The body mass index (BMI) was the most reliable factor for predicting the percentage reduction in the AHI. The OAs also improved the sleep architecture and subjective sleep-related symptoms.
The OAs were effective in patients with moderate or severe OSA. The OAs reduced the mean AHI to 63.9% of the baseline value, and this reduction was influenced by the BMI. Responses to oral appliances (OAs) in obstructive sleep apnea (OSA) vary, and have not been fully evaluated in Korean patients. In this study we aimed to determine the efficacy of OAs for the first-line treatment of Korean patients with moderate or severe OSA.BACKGROUND AND PURPOSEResponses to oral appliances (OAs) in obstructive sleep apnea (OSA) vary, and have not been fully evaluated in Korean patients. In this study we aimed to determine the efficacy of OAs for the first-line treatment of Korean patients with moderate or severe OSA.This multicenter prospective observational study included 45 patients with moderate or severe OSA that had been newly diagnosed between March 2017 and May 2018 and who underwent OA treatment for 1 month. Questionnaires were completed and polysomnography (PSG) was performed before and after OA treatment. The primary outcome measures were improvement in the absolute apnea-hypopnea index (AHI) and the percentage reduction in the AHI. The secondary outcomes were improvements in the questionnaire scores related to sleep-associated symptoms and PSG parameters.METHODSThis multicenter prospective observational study included 45 patients with moderate or severe OSA that had been newly diagnosed between March 2017 and May 2018 and who underwent OA treatment for 1 month. Questionnaires were completed and polysomnography (PSG) was performed before and after OA treatment. The primary outcome measures were improvement in the absolute apnea-hypopnea index (AHI) and the percentage reduction in the AHI. The secondary outcomes were improvements in the questionnaire scores related to sleep-associated symptoms and PSG parameters.The patients were aged 47.4±12.1 years (mean±SD), only two of them were female, and their AHI at baseline was 29.7±10.9/h. After OA treatment the AHI had reduced by 63.9±25.8%, with the reduction was similar between the patients with moderate OSA and those with severe OSA. Overall 31.1% of the patients achieved a normal AHI (<5/h), and 64.4% had an AHI of ≤10/h after the treatment. The body mass index (BMI) was the most reliable factor for predicting the percentage reduction in the AHI. The OAs also improved the sleep architecture and subjective sleep-related symptoms.RESULTSThe patients were aged 47.4±12.1 years (mean±SD), only two of them were female, and their AHI at baseline was 29.7±10.9/h. After OA treatment the AHI had reduced by 63.9±25.8%, with the reduction was similar between the patients with moderate OSA and those with severe OSA. Overall 31.1% of the patients achieved a normal AHI (<5/h), and 64.4% had an AHI of ≤10/h after the treatment. The body mass index (BMI) was the most reliable factor for predicting the percentage reduction in the AHI. The OAs also improved the sleep architecture and subjective sleep-related symptoms.The OAs were effective in patients with moderate or severe OSA. The OAs reduced the mean AHI to 63.9% of the baseline value, and this reduction was influenced by the BMI.CONCLUSIONSThe OAs were effective in patients with moderate or severe OSA. The OAs reduced the mean AHI to 63.9% of the baseline value, and this reduction was influenced by the BMI. Background and Purpose Responses to oral appliances (OAs) in obstructive sleep apnea (OSA) vary, and have not been fully evaluated in Korean patients. In this study we aimed to determine the efficacy of OAs for the first-line treatment of Korean patients with moderate or severe OSA. Methods This multicenter prospective observational study included 45 patients with moderate or severe OSA that had been newly diagnosed between March 2017 and May 2018 and who underwent OA treatment for 1 month. Questionnaires were completed and polysomnography (PSG) was performed before and after OA treatment. The primary outcome measures were improvement in the absolute apnea-hypopnea index (AHI) and the percentage reduction in the AHI. The secondary outcomes were improvements in the questionnaire scores related to sleep-associated symptoms and PSG parameters. Results The patients were aged 47.4±12.1 years (mean±SD), only two of them were female, and their AHI at baseline was 29.7±10.9/h. After OA treatment the AHI had reduced by 63.9± 25.8%, with the reduction was similar between the patients with moderate OSA and those with severe OSA. Overall 31.1% of the patients achieved a normal AHI (<5/h), and 64.4% had an AHI of ≤10/h after the treatment. The body mass index (BMI) was the most reliable factor for predicting the percentage reduction in the AHI. The OAs also improved the sleep architecture and subjective sleep-related symptoms. Conclusions The OAs were effective in patients with moderate or severe OSA. The OAs reduced the mean AHI to 63.9% of the baseline value, and this reduction was influenced by the BMI. KCI Citation Count: 0 |
| Author | Yang, Kwang Ik Cistulli, Peter A. Kim, Dongha Shin, Won Chul Byun, Jung-Ick Cho, Yong Won Ahn, Su-Jin |
| AuthorAffiliation | c Department of Biomaterials & Prosthodontics, Kyung Hee University Hospital at Gangdong, School of Dentistry, Kyung Hee University, Seoul, Korea d Sleep Disorders Center, Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea e Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea f Charles Perkins Centre, School of Medicine, University of Sydney, Sydney, Australia a Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea g Centre for Sleep, Department of Respiratory & Sleep Medicine, Royal North Shore Hospital, Sydney, Australia b Department of Neurology, School of Medicine, Kyunghee University, Seoul, Korea |
| AuthorAffiliation_xml | – name: b Department of Neurology, School of Medicine, Kyunghee University, Seoul, Korea – name: e Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea – name: f Charles Perkins Centre, School of Medicine, University of Sydney, Sydney, Australia – name: d Sleep Disorders Center, Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea – name: g Centre for Sleep, Department of Respiratory & Sleep Medicine, Royal North Shore Hospital, Sydney, Australia – name: c Department of Biomaterials & Prosthodontics, Kyung Hee University Hospital at Gangdong, School of Dentistry, Kyung Hee University, Seoul, Korea – name: a Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Jung-Ick orcidid: 0000-0002-6224-4575 surname: Byun fullname: Byun, Jung-Ick organization: Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea., Department of Neurology, School of Medicine, Kyunghee University, Seoul, Korea – sequence: 2 givenname: Dongha orcidid: 0000-0003-1879-9976 surname: Kim fullname: Kim, Dongha organization: Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea – sequence: 3 givenname: Su-Jin orcidid: 0000-0003-2128-1561 surname: Ahn fullname: Ahn, Su-Jin organization: Department of Biomaterials & Prosthodontics, Kyung Hee University Hospital at Gangdong, School of Dentistry, Kyung Hee University, Seoul, Korea – sequence: 4 givenname: Kwang Ik orcidid: 0000-0001-6343-6520 surname: Yang fullname: Yang, Kwang Ik organization: Sleep Disorders Center, Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea – sequence: 5 givenname: Yong Won orcidid: 0000-0002-6127-1045 surname: Cho fullname: Cho, Yong Won organization: Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea – sequence: 6 givenname: Peter A. orcidid: 0000-0002-7920-4924 surname: Cistulli fullname: Cistulli, Peter A. organization: Charles Perkins Centre, School of Medicine, University of Sydney, Sydney, Australia., Centre for Sleep, Department of Respiratory & Sleep Medicine, Royal North Shore Hospital, Sydney, Australia – sequence: 7 givenname: Won Chul orcidid: 0000-0003-3044-9397 surname: Shin fullname: Shin, Won Chul organization: Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea., Department of Neurology, School of Medicine, Kyunghee University, Seoul, Korea |
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| Title | Efficacy of Oral Appliance Therapy as a First-Line Treatment for Moderate or Severe Obstructive Sleep Apnea: A Korean Prospective Multicenter Observational Study |
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| ispartofPNX | Journal of Clinical Neurology, 2020, 16(2), , pp.215-221 |
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