Fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris
To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The fore...
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| Published in | Journal of dermatology Vol. 41; no. 12; pp. 1069 - 1076 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.12.2014
Wiley Subscription Services, Inc |
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| Abstract | To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a Japanese population. There were significant differences in the amounts of sebum, TG and cutaneous superficial P. acnes, as well as the fatty acid compositions of TG and FFA between acne patients and healthy subjects in females. Their fatty acid compositions were correlated with the amount of TG with or without acne. It was clarified that the fatty acid compositions of TG and FFA depended on the amount of TG, and there were no differences in the fatty acid composition in the presence and absence of acne. |
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| AbstractList | To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a Japanese population. There were significant differences in the amounts of sebum, TG and cutaneous superficial P. acnes, as well as the fatty acid compositions of TG and FFA between acne patients and healthy subjects in females. Their fatty acid compositions were correlated with the amount of TG with or without acne. It was clarified that the fatty acid compositions of TG and FFA depended on the amount of TG, and there were no differences in the fatty acid composition in the presence and absence of acne. To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a Japanese population. There were significant differences in the amounts of sebum, TG and cutaneous superficial P. acnes, as well as the fatty acid compositions of TG and FFA between acne patients and healthy subjects in females. Their fatty acid compositions were correlated with the amount of TG with or without acne. It was clarified that the fatty acid compositions of TG and FFA depended on the amount of TG, and there were no differences in the fatty acid composition in the presence and absence of acne.To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a Japanese population. There were significant differences in the amounts of sebum, TG and cutaneous superficial P. acnes, as well as the fatty acid compositions of TG and FFA between acne patients and healthy subjects in females. Their fatty acid compositions were correlated with the amount of TG with or without acne. It was clarified that the fatty acid compositions of TG and FFA depended on the amount of TG, and there were no differences in the fatty acid composition in the presence and absence of acne. To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides ( TG ) and free fatty acids ( FFA ), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a Japanese population. There were significant differences in the amounts of sebum, TG and cutaneous superficial P. acnes , as well as the fatty acid compositions of TG and FFA between acne patients and healthy subjects in females. Their fatty acid compositions were correlated with the amount of TG with or without acne. It was clarified that the fatty acid compositions of TG and FFA depended on the amount of TG , and there were no differences in the fatty acid composition in the presence and absence of acne. To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a Japanese population. There were significant differences in the amounts of sebum, TG and cutaneous superficial P. acnes, as well as the fatty acid compositions of TG and FFA between acne patients and healthy subjects in females. Their fatty acid compositions were correlated with the amount of TG with or without acne. It was clarified that the fatty acid compositions of TG and FFA depended on the amount of TG, and there were no differences in the fatty acid composition in the presence and absence of acne. |
| Author | Akaza, Narifumi Miyawaki, Masaaki Nakata, Satoru Numata, Shigeki Matsusue, Miyuki Yagami, Akiko Matsunaga, Kayoko Mashima, Yasuo Yamada, Shunji Akamatsu, Hirohiko |
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| Cites_doi | 10.1111/j.1365-2133.2005.06794.x 10.1080/13693780802398026 10.1111/j.1346-8138.1991.tb03122.x 10.1111/j.1346-8138.1991.tb03105.x 10.1126/science.186.4158.19 10.1016/0190-9622(95)90243-0 10.2336/nishinihonhifu.47.1080 10.1128/jcm.28.5.941-943.1990 10.1016/j.chroma.2011.10.095 10.1111/j.1346-8138.2007.00403.x-i1 10.1111/1523-1747.ep12461009 10.1038/jid.1969.157 10.1159/000356777 10.4161/derm.1.2.7811 10.1111/1523-1747.ep12607634 10.1139/m84-096 10.1002/ddr.430130208 10.1194/jlr.R700016-JLR200 10.4049/jimmunol.169.3.1535 10.1038/jid.2009.384 10.1111/j.0022-202X.2005.23705.x 10.1016/j.jdermsci.2007.11.005 10.1159/000069757 10.1128/JCM.40.1.198-204.2002 10.4161/derm.1.3.8473 10.1128/jcm.12.5.672-675.1980 10.1111/j.0022-202X.2005.23682.x |
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| Copyright | 2014 Japanese Dermatological Association 2014 Japanese Dermatological Association. Copyright © 2014 Japanese Dermatological Association |
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| Keywords | triglyceride acne vulgaris sebum Propionibacterium acnes free fatty acid |
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Skin surface lipids and serum lipids in acne vulgaris: a comparative study of young women with and without acne. Nishinihon J Dermatol 1985; 47: 1080-1087. (In Japanese.) Pochi PE. Acne: androgens and microbiology. Drug Dev Res 1988; 13: 157-168. Hayashi N, Akamatsu H, Kawashima M. Establishment of grading criteria for acne severity. J Dermatol 2008; 35: 255-260. Nakatsuji T, Kao MC, Zhang L, Zouboulis CC, Gallo RL, Huang CM. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol 2010; 130: 985-994. Numata S, Akamatsu H, Akaza N, Yagami A, Nakata S, Matsunaga K. Analysis of facial skin-resident microbiota in Japanese acne patients. Dermatology 2014; 228: 86-92. Kim J, Ochoa M-T, Krutzik SR et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002; 168: 1535-1541. Webster G. Inflammation in acne vulgaris. J Am Acad Dermatol 1995; 32: 247-253. 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Destaillats F, Guitard M, Cruz-Hernandez C. Identification of Δ6-monounsaturated fatty acids in human hair and nail samples by gas-chromatography-mass-spectrometry using ionic-liquid coated capillary column. J Chromatogr A 2011; 1218: 9384-9389. Katsuta Y, Iida T, Inomata S, Denda M. Unsaturated fatty acids induce calcium influx into keratinocytes and cause abnormal differentiation of epidermis. J Invest Dermatol 2005; 124: 1008-1013. Papas A, Johnsen S, Liu J-C, Eisinger M. Sebum analysis of individuals with and without acne. Dermatoendocrinology 2009; 1: 157-161. McGinley KJ, Webster GF, Ruggieri MR, Leyden JJ. Regional variations in density of cutaneous propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. J Clin Microbiol 1980; 12: 672-675. Wille JJ, Kydonieus A. Palmitoleic acid isomer (C16:1 delta6) in human skin sebum is effective against gram-positive bacteria. Skin Pharmacol Appl Skin Physiol 2003; 16: 176-187. Drake DR, Brogden KA, Dawson DV, Wertz PW. Thematic review series: skin lipids. Antimicrobial lipid at the skin surface. J Lipid Res 2008; 49: 4-11. Maeda T. Electrons microscopic study of experimentally induced comedo effects of vitamin A acid on comedo formation. J Dermatol 1991; 18: 397-407. Yamamoto A, Serizawa S, Ito M, Sato Y. Effect of aging on sebaceous gland activity and on the fatty acid composition of wax esters. J Invest Dermatol 1987; 89: 507-512. Papas A. Epidermal surface lipids. Dermatoendocrinology 2009; 1: 72-76. 2014; 228 1991; 18 1984; 30 2009; 47 1987; 89 2005; 153 1990; 28 2005; 124 2002; 40 2002; 168 1980; 12 2008; 49 1995; 32 1969; 53 2010; 130 1988; 13 2003; 16 2008; 35 2011; 1218 1975; 65 2008; 50 1974; 186 2009; 1 1985; 47 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_27_1 e_1_2_7_28_1 e_1_2_7_25_1 e_1_2_7_24_1 e_1_2_7_23_1 e_1_2_7_21_1 e_1_2_7_20_1 Downing DT (e_1_2_7_8_1) 1969; 53 Keyworth N (e_1_2_7_22_1) 1990; 28 |
| References_xml | – reference: Hayashi N, Akamatsu H, Kawashima M. Establishment of grading criteria for acne severity. J Dermatol 2008; 35: 255-260. – reference: Ushijima T, Takahashi M, Ozaki Y. Acetic, propionic, and oleic acid as the possible factors influencing the predominant residence of some species of Propionibacterium and coagulase-negative Staphylococcus on normal human skin. Can J Microbiol 1984; 30: 647-652. – reference: Webster G. Inflammation in acne vulgaris. J Am Acad Dermatol 1995; 32: 247-253. – reference: Gollnick HP, Zouboulis CC, Akamatsu H, Kurokawa I, Schulte A. Pathogenesis and pathogenesis related treatment of acne. J Dermatol 1991; 18: 489-499. – reference: Papas A, Johnsen S, Liu J-C, Eisinger M. Sebum analysis of individuals with and without acne. Dermatoendocrinology 2009; 1: 157-161. – reference: Leyden JJ, McGinley KJ, Mills OH, Kligman AM. Propionibacterium levels in patients with and without acne vulgalis. J Invest Dermatol 1975; 65: 382-384. – reference: Kim J, Ochoa M-T, Krutzik SR et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002; 168: 1535-1541. – reference: Nakatsuji T, Kao MC, Zhang L, Zouboulis CC, Gallo RL, Huang CM. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol 2010; 130: 985-994. – reference: Maeda T. Electrons microscopic study of experimentally induced comedo effects of vitamin A acid on comedo formation. J Dermatol 1991; 18: 397-407. – reference: Nicolaides N. Skin lipids: their biochemical uniqueness. Science 1974; 186: 19-26. – reference: Smith RN, Braue A, Varigos GA, Mann NJ. The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides. J Dermatol Sci 2008; 50: 41-52. – reference: Youn SW, Park ES, Lee DH, Huh CH, Park KC. 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| Snippet | To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG)... To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides ( TG... |
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| SubjectTerms | acne vulgaris Acne Vulgaris - metabolism Acne Vulgaris - microbiology Adolescent Adult Case-Control Studies Cross-Sectional Studies Fatty Acids - metabolism Female free fatty acid Humans Male Propionibacterium acnes Propionibacterium acnes - isolation & purification sebum Sebum - metabolism triglyceride Triglycerides - metabolism Young Adult |
| Title | Fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris |
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