Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients - Pautas, E; Moreau, C; Gouin-Thibault, I; Golmard, J-L; Mahé, I; Legendre, C; Taillandier-Hériche, E; Durand-Gasselin, B; Houllier, A-M; Verrier, P; Beaune, P; Loriot, M-A; et al. (Clinical pharmacology and therapeutics, 2010)
Keywords: Age Factors; Aged; Aged, 80 and over; Aryl Hydrocarbon Hydroxylases - genetics; Cohort Studies; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System - genetics; Cytochrome P450 Family 4; Dose-Response Relationship, Drug; Epoxide Hydrolases - genetics; Female; Frail Elderly; Genetic Testing; Genetic Variation - drug effects; Genetic Variation - genetics; Hospitalization - trends; Humans; International Normalized Ratio - trends; Male; Mixed Function Oxygenases - genetics; Polymorphism, Genetic - genetics; Prospective Studies; Risk Factors; Vitamin K Epoxide Reductases; Warfarin - pharmacology