Antibody Pharmacokinetics and Pharmacodynamics

• Published in: Journal of pharmaceutical sciences Vol. 93; no. 11; pp. 2645 - 2668
• Main Authors: Lobo, Evelyn D., Hansen, Ryan J., Balthasar, Joseph P.
• Format: Journal Article
• Language: English
• Published: Hoboken Elsevier Inc 01.11.2004; Wiley Subscription Services, Inc., A Wiley Company; Wiley; American Pharmaceutical Association
• Subjects: Animals; Antibodies - chemistry; Antibodies - metabolism; Antibodies - pharmacology; Binding Sites, Antibody - drug effects; Binding Sites, Antibody - physiology; Biological and medical sciences; General pharmacology; Humans; Immunoglobulin Fragments - chemistry; Immunoglobulin Fragments - metabolism; Immunoglobulin Fragments - pharmacology; Medical sciences; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - metabolism; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Pharmacokinetic pharmacodynamic relationship; Antibody; Pharmaceutical technology

The U.S. Food and Drug administration (FDA) has approved several polyclonal antibody preparations and at least 18 monoclonal antibody preparations (antibodies, antibody fragments, antibody fusion proteins, etc.). These drugs, which may be considered as a diverse group of therapeutic proteins, are as...