Cyclic biaxial strain affects U937 macrophage-like morphology and enzymatic activities

• Published in: Journal of biomedical materials research. Part A Vol. 76A; no. 1; pp. 52 - 62
• Main Authors: Matheson, Loren A., Maksym, Geoffrey N., Santerre, J. Paul, Labow, Rosalind S.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2006
• Subjects: Alkaline Phosphatase - metabolism; biaxial strain; Biocompatible Materials; Biodegradation, Environmental; Cell Differentiation; Cell Movement; Cell Shape; esterases; Esterases - metabolism; Foreign-Body Reaction; Humans; macrophages; Macrophages - cytology; Macrophages - enzymology; Macrophages - physiology; Materials Testing; Mechanotransduction, Cellular; Microscopy, Electron, Scanning; Phenotype; siloxane; Stress, Mechanical; U937 Cells

As monocytes migrate to the site of a foreign body and differentiate into mature monocyte‐derived macrophages (MDMs), the cells undergo a morphological transformation that involves mechanical stimulation via membrane stretch. Because the site of many cardiovascular implant devices includes substrate...