E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas

• Published in: The FASEB journal Vol. 37; no. 7; p. e23058
• Main Authors: Lin, Kuan-Hung, Lee, Sue Chin, Dacheux, Mélanie A, Norman, Derek D, Balogh, Andrea, Bavaria, Mitul, Lee, Hsinyu, Tigyi, Gabor
• Format: Journal Article
• Language: English
• Published: United States 01.07.2023
• Subjects: Animals; Chromosomes; E2F7 Transcription Factor - genetics; E2F7 Transcription Factor - metabolism; Fibroblasts - metabolism; Gene Expression Regulation; Humans; Lysophospholipids - metabolism; Mice; Phosphoric Diester Hydrolases - genetics; Phosphoric Diester Hydrolases - metabolism; Signal Transduction; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism

Dysregulation of the autotaxin (ATX, Enpp2)-lysophosphatidic acid (LPA) signaling in cancerous cells contributes to tumorigenesis and therapy resistance. We previously found that ATX activity was elevated in p53-KO mice compared to wild-type (WT) mice. Here, we report that ATX expression was upregul...