Immunohistochemical detection for nuclear β-catenin in sporadic basal cell carcinoma

• Published in: British journal of dermatology (1951) Vol. 145; no. 5; pp. 771 - 777
• Main Authors: Yamazaki, F., Aragane, Y., Kawada, A., Tezuka, T.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.11.2001; Blackwell
• Subjects: basal cell carcinoma; beta Catenin; Biological and medical sciences; Carcinoma, Basal Cell - chemistry; Carcinoma, Squamous Cell - chemistry; Cell Membrane - chemistry; Cell Nucleus - chemistry; Cytoskeletal Proteins - analysis; Dermatitis, Atopic - metabolism; Dermatology; Fluorescent Antibody Technique; Humans; Medical sciences; Neoplasm Proteins - analysis; nuclear localization; Psoriasis - metabolism; Skin - chemistry; Skin Neoplasms - chemistry; Trans-Activators; tumorigenesis; Tumors of the skin and soft tissue. Premalignant lesions; β-catenin; Human; Immunohistochemistry; Pathology; Skin disease; Basal cell carcinoma; Pathogenesis; Cell nucleus; Malignant tumor; Detection; Carcinogenesis; Catenin

Background Despite the increasing incidence of basal cell carcinoma (BCC), its pathogenesis has remained largely unknown. Recently, it was reported that genes involved in tissue morphogenesis, such as sonic hedgehog or patched, were found to be mutated in BCC, suggesting the involvement of those mol...