Adenocarcinoma of the anal canal - a systematic review

Aim The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma. Method A systematic review of the literature was performed for studies in the English language publishe...

Full description

Saved in:
Bibliographic Details
Published inColorectal disease Vol. 15; no. 12; pp. 1481 - 1488
Main Authors Anwar, S., Welbourn, H., Hill, J., Sebag-Montefiore, D.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.12.2013
Subjects
abdominoperineal resection
adenocarcinoma
Adenocarcinoma - therapy
Anal
Anal Canal - surgery
Anus Neoplasms - therapy
chemo radiotherapy
Chemoradiotherapy, Adjuvant - methods
Chemotherapy, Adjuvant
Humans
Neoadjuvant Therapy - methods
Neoplasm Recurrence, Local
Prognosis
Radiotherapy, Adjuvant
Treatment Outcome
adenocarcinoma
chemo radiotherapy
abdominoperineal resection
Anal
Online AccessGet full text

Cover

Abstract Aim The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma. Method A systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion. Results Sixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy. Conclusion The prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre‐ or postoperative chemoradiotherapy offers the best chance of survival.
AbstractList The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma. A systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion. Sixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy. The prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre- or postoperative chemoradiotherapy offers the best chance of survival.
AIMThe prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma.METHODA systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion.RESULTSSixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy.CONCLUSIONThe prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre- or postoperative chemoradiotherapy offers the best chance of survival.
Aim The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma. Method A systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion. Results Sixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy. Conclusion The prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre‐ or postoperative chemoradiotherapy offers the best chance of survival.
Abstract Aim The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the management of anal adenocarcinoma. Method A systematic review of the literature was performed for studies in the English language published between 1950 and 2011. All those that focused on the management of anal adenocarcinoma were considered for inclusion. Results Sixteen retrospective observational studies were identified; no randomized trials were found. Most of the studies contained small numbers of patients due to the rarity of anal adenocarcinoma. Treatment included local excision), radiotherapy, chemotherapy, chemoradiotherapy and abdominoperineal excision. Most studies concluded that a multimodality approach, combining radical surgical resection with neoadjuvant/adjuvant chemoradiotherapy was the optimal management strategy. Conclusion The prognosis of anal adenocarcinoma is poor, and there is little information on the optimal management. The relevant studies indicate that a combination of radical surgical resection and pre‐ or postoperative chemoradiotherapy offers the best chance of survival.
Author Anwar, S.
Sebag-Montefiore, D.
Hill, J.
Welbourn, H.
Author_xml – sequence: 1
  givenname: S.
  surname: Anwar
  fullname: Anwar, S.
  email: : Mr S. Anwar, Consultant General Surgeon, Calderdale and Huddersfield NHS Trust, Huddersfield Royal Infirmary, Lindley, Huddersfield HD3 3EA, UK., suanwar@btinternet.com
  organization: Department of Colorectal Surgery, Calderdale and Huddersfield NHS Trust, Huddersfield, UK
– sequence: 2
  givenname: H.
  surname: Welbourn
  fullname: Welbourn, H.
  organization: Department of Colorectal Surgery, Calderdale and Huddersfield NHS Trust, Huddersfield, UK
– sequence: 3
  givenname: J.
  surname: Hill
  fullname: Hill, J.
  organization: Department of Colorectal Surgery, Central Manchester University Hospitals, Manchester, UK
– sequence: 4
  givenname: D.
  surname: Sebag-Montefiore
  fullname: Sebag-Montefiore, D.
  organization: Department of Oncology, St James's Institute of Oncology, Leeds Teaching Hospitals, Leeds, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23809885$$D View this record in MEDLINE/PubMed
BookMark eNp9kE9PwjAYhxuDEVAvfgCzozEZru26dUcCgiREYoJ6bNruXazuD7ZD5Ns7GHC0h7aH5_d78z591CmrEhC6wcEAN-dBV6kZYEIJO0M9HEbUxxTzzv5PfJ7goIv6zn0GAY5izC9Ql1AeJJyzHoqGKZSVllabsiqkV2Ve_QGeLGXu6f3te9JzW1dDIWujPQs_BjZX6DyTuYPrw3uJXiePy9GTP19MZ6Ph3NchpczncaRJGkGkFVFhCqFu5magAqKIVDRhYSK5YjjLYkiimDCmJMeU4SCUVKWMXqK7tndlq-81uFoUxmnIc1lCtXai2RBTmsQ8adD7FtW2cs5CJlbWFNJuBQ7EzpPYeRJ7Tw18e-hdqwLSE3oU0wC4BTYmh-0_VWK0GM-OpX6bMY2t31NG2i8RxTRm4v15KsLxZPkSkzfB6B8vC4HB
CitedBy_id crossref_primary_10_1136_bmjgast_2021_000661
crossref_primary_10_17235_reed_2018_5657_2018
crossref_primary_10_1016_j_ctrc_2015_10_003
crossref_primary_10_1245_s10434_019_07202_4
crossref_primary_10_12998_wjcc_v10_i3_1122
crossref_primary_10_1155_2020_5139236
crossref_primary_10_1007_s00384_022_04211_w
crossref_primary_10_1080_03007995_2018_1441817
crossref_primary_10_1016_j_ijrobp_2019_06_2544
crossref_primary_10_1097_DCR_0000000000001506
crossref_primary_10_1155_2018_4017043
crossref_primary_10_1016_j_suc_2020_02_007
crossref_primary_10_1097_MD_0000000000013877
crossref_primary_10_1186_s13000_015_0379_9
crossref_primary_10_3390_cancers14153738
crossref_primary_10_1038_s41416_018_0049_2
crossref_primary_10_1007_s12328_016_0688_x
crossref_primary_10_2147_IMCRJ_S350999
crossref_primary_10_1097_DCR_0000000000001874
crossref_primary_10_1016_j_jcol_2018_08_001
crossref_primary_10_1111_1346_8138_13633
crossref_primary_10_1093_jscr_rjad334
crossref_primary_10_1158_1055_9965_EPI_15_0044
crossref_primary_10_1371_journal_pone_0219937
crossref_primary_10_1016_j_clcc_2020_04_001
crossref_primary_10_1093_ecco_jcc_jjx035
crossref_primary_10_1245_s10434_019_07466_w
crossref_primary_10_1111_codi_17054
crossref_primary_10_1016_j_lpm_2018_05_009
crossref_primary_10_1016_j_ejcskn_2023_100002
crossref_primary_10_1016_j_ijscr_2019_03_019
crossref_primary_10_1007_s10863_019_09792_w
crossref_primary_10_1016_j_suronc_2021_101551
crossref_primary_10_1093_ije_dyw276
crossref_primary_10_17235_reed_2023_9791_2023
crossref_primary_10_1007_s13126_017_0375_5
Cites_doi 10.1007/BF02554358
10.1177/000313480306900218
10.1007/BF02053944
10.1002/(SICI)1097-0142(19970815)80:4<805::AID-CNCR20>3.0.CO;2-W
10.1016/S0002-9610(99)80143-3
10.1016/S0360-3016(99)00267-9
10.1002/ibd.21228
10.1111/j.1463-1318.2005.00934.x
10.1002/jso.2930230407
10.1001/archsurg.1957.01280150042005
10.1016/S0360-3016(02)04118-4
10.1016/S0360-3016(00)01540-6
10.1007/DCR.0b013e318197d0ad
10.1001/archsurg.1964.01320060057011
10.1177/014107688808100411
10.1136/gut.35.3.347
10.1007/s10350-004-6740-9
10.1136/jcp.49.12.1009
10.1016/S0360-3016(03)00277-3
10.1007/s11605-009-1061-x
10.1002/(SICI)1097-0142(19990415)85:8<1686::AID-CNCR7>3.0.CO;2-7
10.1097/PAT.0b013e328340e4d6
10.1007/DCR.0b013e3181a79589
10.1002/cncr.20364
10.1007/BF02237388
10.1002/(SICI)1096-9098(199703)64:3<218::AID-JSO8>3.0.CO;2-D
ContentType Journal Article
Copyright 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
Copyright_xml – notice: 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland
– notice: 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
DBID BSCLL
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1111/codi.12325
DatabaseName Istex
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic

CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1463-1318
EndPage 1488
ExternalDocumentID 10_1111_codi_12325
23809885
CODI12325
ark_67375_WNG_4DFTQ72V_5
Genre reviewArticle
Journal Article
Review
GroupedDBID ---
.3N
.GA
.Y3
05W
0R~
10A
1OC
29F
31~
33P
36B
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5GY
5HH
5LA
5VS
66C
6J9
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHHS
AANLZ
AAONW
AASGY
AAXRX
AAZKR
ABCQN
ABCUV
ABEML
ABJNI
ABPVW
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFO
ACGFS
ACGOF
ACMXC
ACPOU
ACPRK
ACSCC
ACXBN
ACXQS
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADOZA
ADXAS
ADZMN
ADZOD
AEEZP
AEGXH
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFEBI
AFFPM
AFGKR
AFPWT
AFRAH
AFZJQ
AHBTC
AIACR
AIAGR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BSCLL
BY8
C45
CAG
COF
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
EBS
EJD
ESX
EX3
F00
F01
F04
F5P
FEDTE
FUBAC
G-S
G.N
GODZA
H.X
HF~
HGLYW
HVGLF
HZI
HZ~
IHE
IX1
J0M
KBYEO
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
O66
O9-
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
Q.N
Q11
QB0
R.K
ROL
RX1
SUPJJ
TEORI
UB1
V8K
V9Y
W8V
W99
WBKPD
WHWMO
WIH
WIJ
WIK
WOHZO
WOW
WQJ
WRC
WVDHM
WXI
WXSBR
XG1
YFH
YUY
ZZTAW
~IA
~WT
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c4335-876c2d6e6cb2b4de4c809feb02b2ab39549a8b51ff7e967255ba8135104a3bd53
IEDL.DBID DR2
ISSN 1462-8910
IngestDate Fri Aug 16 23:50:41 EDT 2024
Fri Aug 23 00:39:41 EDT 2024
Tue Aug 27 13:50:53 EDT 2024
Sat Aug 24 01:15:49 EDT 2024
Wed Oct 30 09:53:29 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords adenocarcinoma
chemo radiotherapy
abdominoperineal resection
Anal
Language English
License 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4335-876c2d6e6cb2b4de4c809feb02b2ab39549a8b51ff7e967255ba8135104a3bd53
Notes ArticleID:CODI12325
ark:/67375/WNG-4DFTQ72V-5
istex:D81E249750E1D001E2A3FC1D65327FF3C5547E5C
SourceType-Scholarly Journals-1
ObjectType-Feature-4
ObjectType-Undefined-1
content type line 23
ObjectType-Review-2
ObjectType-Article-3
PMID 23809885
PQID 1461339789
PQPubID 23479
PageCount 8
ParticipantIDs proquest_miscellaneous_1461339789
crossref_primary_10_1111_codi_12325
pubmed_primary_23809885
wiley_primary_10_1111_codi_12325_CODI12325
istex_primary_ark_67375_WNG_4DFTQ72V_5
PublicationCentury 2000
PublicationDate December 2013
PublicationDateYYYYMMDD 2013-12-01
PublicationDate_xml – month: 12
  year: 2013
  text: December 2013
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Colorectal disease
PublicationTitleAlternate Colorectal Dis
PublicationYear 2013
Publisher Blackwell Publishing Ltd
Publisher_xml – name: Blackwell Publishing Ltd
References Neilson OV, Koch F. Carcinomas of the anorectal region of extramucosal origin with special reference to the anal ducts. Acta Chir Scand 1973; 139: 299-305.
Beal KP, Wong D, Guillem JG et al. Primary adenocarcinoma of the anus treated with combined modality therapy. Dis Colon Rectum 2003; 46: 1320-4.
Klas JV, Rothenberger DA, Wong WD, Madoff RD. Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes. Cancer 1999; 85: 1686-93.
Devon KM, Brown CJ, Burnstein M, McLeod RS. Cancer of the anus complicating perianal Crohn's disease. Dis Colon Rectum 2009; 52: 211-6.
Thomas M, Bienkowski R, Vandermeer TJ, Trostle D, Cagir B. Malignant transformation in perianal fistulas of Crohn's disease: a systematic review of the literature. J Gastrointest Surg 2010; 14: 66-73.
Wong MTC, Lim JF, Eu KW. Anal canal malignancies: a review in an Asian population. SMJ 2011; 52: 9-14.
Schaffzin DM, Stahl TJ, Smith LE. Perianal mucinous adenocarcinoma: unusual case presentations and review of the literature. Am Surg 2003 Feb; 69: 166-9.
Myerson RJ, Karnell LH, Menck HR. The National Cancer Data Base report on carcinoma of the anus. Cancer 1997; 80: 805-15.
Ball CS, Wujanto R, Haboubi NY, Schofield PF. Carcinoma in anal Crohn's disease: discussion paper. J R Soc Med 1988; 81: 217-9.
Sengul N, Wexner SD, Woodhouse S et al. Effects of radiotherapy on different histopathological types of rectal carcinoma. Colorectal Dis 2006; 8: 283-8.
Wolff P, Peiffert D. In regard to Joon et al. IJROBP 1999;45:1199-1205. Int J Radiat Oncol Biol Phys 2001; 49: 1517.
Buckwalter JA, Jurayj MN. Relationship of anorectal disease to carcinoma. Arch Surg 1957; 75: 352-61.
Abel ME, Chiu YSY, Russell TR, Volpe PA. Adenocarcinoma of the anal glands: results of a survey. Dis Colon Rectum 1993; 36: 383-7.
Nishigami T, Kataoka TR, Ikeuchi H et al. Adenocarcinomas associated with perineal fistulae in Crohn's disease have a rectal, not an anal, immunophenotype. Pathology 2011; 43: 36-9.
Jensen SL, Shokouh-Amiri MH, Hagen K, Harling H, Nielsen OV. Adenocarcinoma of the anal ducts. A series of 21 cases. Dis Colon Rectum 1988; 31: 268-72.
Li LR, Wan DS, Pan ZZ et al. Clinical features and treatment of 49 patients with anal canal adenocarcinoma. Chin J Gastrointest Surg 2006; 9: 402-4.
Berg HK. Adenocarcinoma of the anal canal. Md Med J 1990; 39: 675-8.
Belkacemi Y, Berger C, Poortmans P et al. Management of primary anal canal adenocarcinoma: a large retrospective study from the Rare Cancer Network. Int J Radiat Oncol Biol Phys 2003; 56: 1274-83.
Basik M, Rodriguez-Bigas MA, Penetrante R, Petrelli NJ. Prognosis and recurrence patterns of anal adenocarcinoma. Am J Surg 1995; 169: 233-7.
Chang GJ, Gonzalez RJ, Skibber JM, Eng C, Das P, Rodriguez-Bigas MA. A twenty-year experience with adenocarcinoma of the anal canal. Dis Colon Rectum 2009; 52: 1375-80.
Bosset JF, Calais G, Mineur L et al. Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results-EORTC 22921. Colorectal Dis 2006; 8: 283-8.
Connell WR, Sheffield JP, Kamm MA, Ritchie JK, Hawley PR, Lennard-Jones JE. Lower gastrointestinal malignancy in Crohn's disease. Gut 1994; 35: 347-52.
Behan WMH, Burnett RA. Adenocarcinoma of the anal glands. J Clin Pathol 1996; 49: 1009-11.
Kline RJ, Spencer RJ, Harrison RG. Carcinoma associated with fistula in ano. Arch Surg 1964; 89: 989-94.
Papagikos M, Crane CH, Skibber J et al. Chemoradiation for adenocarcinoma of the anus. Int J Radiat Oncol Biol Phys 2003; 55: 669-78.
Iesalnieks I, Gaertner WB, Glass H, Strauch U, Hipp M, Schlitt HJ. Fistula-associated anal adenocarcinoma in Crohn's disease. Inflamm Bowel Dis 2010; 16: 1643-8.
Anthony T, Simmang C, Lee EL, Turnage RH. Perinal mucinous adenocarcinoma. J Surg Oncol 1997; 64: 218-21.
Longo WE, Vernava AM, Wade TP, Coplin MA, Virgo KS, Johnson FE. Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment. Am Surg 1995; 61: 495-500.
Joon DL, Chao MWT, Ngan SYK, Joon ML, Guiney MJ. Primary adenocarcinoma of the anus: a retrospective analysis. Int J Radiat Oncol Biol Phys 1999; 45: 1199-205.
Zaren HA, Delone FX, Lerner HJ. Carcinoma of the anal gland: case report and review of the literature. J Surg Oncol 1983; 23: 250-4.
Johnson LG, Madeleine MM, Newcomer LM, Schwartz SM, Daling JR. Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973-2000. Cancer 2004; 101: 281-8.
Ky A, Sohn N, Weinstein MA, Korelitz BI. Carcinoma arising in anorectal fistulas of Crohn's disease. Dis Colon Rectum 1998; 41: 992-6.
2004; 101
1997; 80
1957; 75
2010; 16
2010; 14
1990; 39
1997; 64
2006; 9
1999; 45
2011; 52
2006; 8
2001; 49
1999; 85
1964; 89
1988; 31
1998; 41
2003; 55
2003; 56
1993; 36
1995; 61
2009; 52
1973; 139
2003; 46
2003; 69
1994; 35
2011; 43
1995; 169
1988; 81
1996; 49
1983; 23
e_1_2_7_6_1
e_1_2_7_5_1
e_1_2_7_3_1
Berg HK (e_1_2_7_4_1) 1990; 39
e_1_2_7_9_1
Schaffzin DM (e_1_2_7_33_1) 2003; 69
e_1_2_7_8_1
e_1_2_7_7_1
Neilson OV (e_1_2_7_12_1) 1973; 139
e_1_2_7_19_1
e_1_2_7_18_1
e_1_2_7_17_1
e_1_2_7_16_1
e_1_2_7_2_1
e_1_2_7_15_1
e_1_2_7_14_1
e_1_2_7_13_1
e_1_2_7_11_1
e_1_2_7_10_1
e_1_2_7_26_1
e_1_2_7_27_1
Longo WE (e_1_2_7_23_1) 1995; 61
Wong MTC (e_1_2_7_29_1) 2011; 52
e_1_2_7_30_1
e_1_2_7_25_1
e_1_2_7_24_1
e_1_2_7_32_1
e_1_2_7_22_1
e_1_2_7_21_1
e_1_2_7_20_1
Bosset JF (e_1_2_7_31_1) 2006; 8
Li LR (e_1_2_7_28_1) 2006; 9
References_xml – volume: 52
  start-page: 211
  year: 2009
  end-page: 6
  article-title: Cancer of the anus complicating perianal Crohn's disease
  publication-title: Dis Colon Rectum
– volume: 49
  start-page: 1517
  year: 2001
  article-title: In regard to Joon et al. IJROBP 1999;45:1199–1205
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 36
  start-page: 383
  year: 1993
  end-page: 7
  article-title: Adenocarcinoma of the anal glands: results of a survey
  publication-title: Dis Colon Rectum
– volume: 35
  start-page: 347
  year: 1994
  end-page: 52
  article-title: Lower gastrointestinal malignancy in Crohn's disease
  publication-title: Gut
– volume: 89
  start-page: 989
  year: 1964
  end-page: 94
  article-title: Carcinoma associated with fistula in ano
  publication-title: Arch Surg
– volume: 56
  start-page: 1274
  year: 2003
  end-page: 83
  article-title: Management of primary anal canal adenocarcinoma: a large retrospective study from the Rare Cancer Network
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 80
  start-page: 805
  year: 1997
  end-page: 15
  article-title: The National Cancer Data Base report on carcinoma of the anus
  publication-title: Cancer
– volume: 9
  start-page: 402
  year: 2006
  end-page: 4
  article-title: Clinical features and treatment of 49 patients with anal canal adenocarcinoma
  publication-title: Chin J Gastrointest Surg
– volume: 85
  start-page: 1686
  year: 1999
  end-page: 93
  article-title: Malignant tumors of the anal canal: the spectrum of disease, treatment, and outcomes
  publication-title: Cancer
– volume: 52
  start-page: 1375
  year: 2009
  end-page: 80
  article-title: A twenty‐year experience with adenocarcinoma of the anal canal
  publication-title: Dis Colon Rectum
– volume: 75
  start-page: 352
  year: 1957
  end-page: 61
  article-title: Relationship of anorectal disease to carcinoma
  publication-title: Arch Surg
– volume: 81
  start-page: 217
  year: 1988
  end-page: 9
  article-title: Carcinoma in anal Crohn's disease: discussion paper
  publication-title: J R Soc Med
– volume: 52
  start-page: 9
  year: 2011
  end-page: 14
  article-title: Anal canal malignancies: a review in an Asian population
  publication-title: SMJ
– volume: 41
  start-page: 992
  year: 1998
  end-page: 6
  article-title: Carcinoma arising in anorectal fistulas of Crohn's disease
  publication-title: Dis Colon Rectum
– volume: 39
  start-page: 675
  year: 1990
  end-page: 8
  article-title: Adenocarcinoma of the anal canal
  publication-title: Md Med J
– volume: 169
  start-page: 233
  year: 1995
  end-page: 7
  article-title: Prognosis and recurrence patterns of anal adenocarcinoma
  publication-title: Am J Surg
– volume: 23
  start-page: 250
  year: 1983
  end-page: 4
  article-title: Carcinoma of the anal gland: case report and review of the literature
  publication-title: J Surg Oncol
– volume: 14
  start-page: 66
  year: 2010
  end-page: 73
  article-title: Malignant transformation in perianal fistulas of Crohn's disease: a systematic review of the literature
  publication-title: J Gastrointest Surg
– volume: 101
  start-page: 281
  year: 2004
  end-page: 8
  article-title: Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973‐2000
  publication-title: Cancer
– volume: 55
  start-page: 669
  year: 2003
  end-page: 78
  article-title: Chemoradiation for adenocarcinoma of the anus
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 8
  start-page: 283
  year: 2006
  end-page: 8
  article-title: Effects of radiotherapy on different histopathological types of rectal carcinoma
  publication-title: Colorectal Dis
– volume: 31
  start-page: 268
  year: 1988
  end-page: 72
  article-title: Adenocarcinoma of the anal ducts. A series of 21 cases
  publication-title: Dis Colon Rectum
– volume: 8
  start-page: 283
  year: 2006
  end-page: 8
  article-title: Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results–EORTC 22921
  publication-title: Colorectal Dis
– volume: 69
  start-page: 166
  year: 2003
  end-page: 9
  article-title: Perianal mucinous adenocarcinoma: unusual case presentations and review of the literature
  publication-title: Am Surg
– volume: 45
  start-page: 1199
  year: 1999
  end-page: 205
  article-title: Primary adenocarcinoma of the anus: a retrospective analysis
  publication-title: Int J Radiat Oncol Biol Phys
– volume: 46
  start-page: 1320
  year: 2003
  end-page: 4
  article-title: Primary adenocarcinoma of the anus treated with combined modality therapy
  publication-title: Dis Colon Rectum
– volume: 64
  start-page: 218
  year: 1997
  end-page: 21
  article-title: Perinal mucinous adenocarcinoma
  publication-title: J Surg Oncol
– volume: 43
  start-page: 36
  year: 2011
  end-page: 9
  article-title: Adenocarcinomas associated with perineal fistulae in Crohn's disease have a rectal, not an anal, immunophenotype
  publication-title: Pathology
– volume: 139
  start-page: 299
  year: 1973
  end-page: 305
  article-title: Carcinomas of the anorectal region of extramucosal origin with special reference to the anal ducts
  publication-title: Acta Chir Scand
– volume: 61
  start-page: 495
  year: 1995
  end-page: 500
  article-title: Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment
  publication-title: Am Surg
– volume: 16
  start-page: 1643
  year: 2010
  end-page: 8
  article-title: Fistula‐associated anal adenocarcinoma in Crohn's disease
  publication-title: Inflamm Bowel Dis
– volume: 49
  start-page: 1009
  year: 1996
  end-page: 11
  article-title: Adenocarcinoma of the anal glands
  publication-title: J Clin Pathol
– ident: e_1_2_7_19_1
  doi: 10.1007/BF02554358
– volume: 69
  start-page: 166
  year: 2003
  ident: e_1_2_7_33_1
  article-title: Perianal mucinous adenocarcinoma: unusual case presentations and review of the literature
  publication-title: Am Surg
  doi: 10.1177/000313480306900218
  contributor:
    fullname: Schaffzin DM
– ident: e_1_2_7_16_1
  doi: 10.1007/BF02053944
– volume: 52
  start-page: 9
  year: 2011
  ident: e_1_2_7_29_1
  article-title: Anal canal malignancies: a review in an Asian population
  publication-title: SMJ
  contributor:
    fullname: Wong MTC
– ident: e_1_2_7_17_1
  doi: 10.1002/(SICI)1097-0142(19970815)80:4<805::AID-CNCR20>3.0.CO;2-W
– ident: e_1_2_7_3_1
  doi: 10.1016/S0002-9610(99)80143-3
– ident: e_1_2_7_21_1
  doi: 10.1016/S0360-3016(99)00267-9
– ident: e_1_2_7_13_1
  doi: 10.1002/ibd.21228
– volume: 8
  start-page: 283
  year: 2006
  ident: e_1_2_7_31_1
  article-title: Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results–EORTC 22921
  publication-title: Colorectal Dis
  contributor:
    fullname: Bosset JF
– ident: e_1_2_7_32_1
  doi: 10.1111/j.1463-1318.2005.00934.x
– ident: e_1_2_7_7_1
  doi: 10.1002/jso.2930230407
– volume: 139
  start-page: 299
  year: 1973
  ident: e_1_2_7_12_1
  article-title: Carcinomas of the anorectal region of extramucosal origin with special reference to the anal ducts
  publication-title: Acta Chir Scand
  contributor:
    fullname: Neilson OV
– ident: e_1_2_7_5_1
  doi: 10.1001/archsurg.1957.01280150042005
– ident: e_1_2_7_2_1
  doi: 10.1016/S0360-3016(02)04118-4
– ident: e_1_2_7_22_1
  doi: 10.1016/S0360-3016(00)01540-6
– ident: e_1_2_7_30_1
  doi: 10.1007/DCR.0b013e318197d0ad
– ident: e_1_2_7_6_1
  doi: 10.1001/archsurg.1964.01320060057011
– volume: 61
  start-page: 495
  year: 1995
  ident: e_1_2_7_23_1
  article-title: Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment
  publication-title: Am Surg
  contributor:
    fullname: Longo WE
– ident: e_1_2_7_8_1
  doi: 10.1177/014107688808100411
– ident: e_1_2_7_10_1
  doi: 10.1136/gut.35.3.347
– ident: e_1_2_7_26_1
  doi: 10.1007/s10350-004-6740-9
– ident: e_1_2_7_18_1
  doi: 10.1136/jcp.49.12.1009
– ident: e_1_2_7_20_1
  doi: 10.1016/S0360-3016(03)00277-3
– volume: 9
  start-page: 402
  year: 2006
  ident: e_1_2_7_28_1
  article-title: Clinical features and treatment of 49 patients with anal canal adenocarcinoma
  publication-title: Chin J Gastrointest Surg
  contributor:
    fullname: Li LR
– ident: e_1_2_7_14_1
  doi: 10.1007/s11605-009-1061-x
– ident: e_1_2_7_25_1
  doi: 10.1002/(SICI)1097-0142(19990415)85:8<1686::AID-CNCR7>3.0.CO;2-7
– ident: e_1_2_7_15_1
  doi: 10.1097/PAT.0b013e328340e4d6
– ident: e_1_2_7_27_1
  doi: 10.1007/DCR.0b013e3181a79589
– ident: e_1_2_7_11_1
  doi: 10.1002/cncr.20364
– ident: e_1_2_7_9_1
  doi: 10.1007/BF02237388
– volume: 39
  start-page: 675
  year: 1990
  ident: e_1_2_7_4_1
  article-title: Adenocarcinoma of the anal canal
  publication-title: Md Med J
  contributor:
    fullname: Berg HK
– ident: e_1_2_7_24_1
  doi: 10.1002/(SICI)1096-9098(199703)64:3<218::AID-JSO8>3.0.CO;2-D
SSID ssj0016718
Score 2.2807438
SecondaryResourceType review_article
Snippet Aim The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in...
The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in the...
Abstract Aim The prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current...
AIMThe prognosis of anal adenocarcinoma is poor and the management remains controversial. We carried out a literature review to identify current practice in...
SourceID proquest
crossref
pubmed
wiley
istex
SourceType Aggregation Database
Index Database
Publisher
StartPage 1481
SubjectTerms abdominoperineal resection
adenocarcinoma
Adenocarcinoma - therapy
Anal
Anal Canal - surgery
Anus Neoplasms - therapy
chemo radiotherapy
Chemoradiotherapy, Adjuvant - methods
Chemotherapy, Adjuvant
Humans
Neoadjuvant Therapy - methods
Neoplasm Recurrence, Local
Prognosis
Radiotherapy, Adjuvant
Treatment Outcome
Title Adenocarcinoma of the anal canal - a systematic review
URI https://api.istex.fr/ark:/67375/WNG-4DFTQ72V-5/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcodi.12325
https://www.ncbi.nlm.nih.gov/pubmed/23809885
https://search.proquest.com/docview/1461339789
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwEA-iIL74_TG_qCg-CB1tk7Yp-DKccwpOlE33IiVJU5DhKvsA8cn_wf_Qv8S7dJ1ORNCX0tJLSe9yubvk7hdCDigiovAktSNJmc2Y59rS1cpWyuVCaN9NTXn0ZSOot9hF229PkeOiFibHhxgvuKFmmPkaFVzI_hclV1nyUEaHACvMXRpiPlf1Zowd5QahWdyDmQBUHoziCJsU03g-m05Yoxlk7PNPruak52pMT22B3BedzjNOOuXhQJbVyzc8x__-1SKZH_mkViUfREtkSneXyezlaNd9hfAKTE5g83rwmD0KK0stcBstgY2Uub6_vlnC-kSFtvKKmFXSqp02T-r26MQFWzFKfZwalZcEOlDSkyzRTHEnSrV0POkJSXFLUHAJAkxDHQUhhCNScDzjz2GCysSna2S6m3X1BrESxLpLwPxHAl4KjJScgGsKZBGLmFsi-wXn46ccWCMuAhJkQmyYUCKHRihjEtHrYCpa6Md3jbOYVWvN69C7jYFwr5BaDAqCux6iq7NhH2MbiMMhWI5KZD0X5_hr4K84EefQ-sgI5ZeexCdX1XNzt_kX4i0y5-EBGiYBZptMD3pDvQNuzEDumuH6AfAW6pc
link.rule.ids 315,783,787,1378,27936,27937,46306,46730
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fb9MwELdYK7G9DAaDlQELAvEwKVUSO4nzWLWUdrRFoBb6ZtmOI03Vkql_pGlPfAe-IZ9kd07aUoSQ2EuUKOcoucv9s8-_I-QdRUQUnmZuoihzGQt8V_lGu1r7XEoT-pndHj0cRb0Ju5iG06o2B_fClPgQmwk31Axrr1HBcUL6Ny3XRXrZxIgg3CN10HeKnRs6XzfoUX4U2-k9sAWg9OAWK3RSLOTZjt3xR3Vk7c3fgs3d2NU6n-6jssPqwmIWYs3JrLlaqqa-_QPR8d7f9ZgcVmGp0yr_oyPywORPyMNhtfD-lPAW2Cdwe3O4LK6kU2QORI6OxEHaHn_9-OlIZwsM7ZSbYo7JpPth3O65VdMFVzNKQ7SOOkgjE2kVKJYaprmXZEZ5gQqkorgqKLkCGWaxSaIYMhIlObb585ikKg3pM1LLi9ycECdFuLsUIoBEwk2JyZIXcUOBLGEJ8xvk7Zr14rrE1hDrnASZICwTGuS9lcqGRM5nWI0Wh-L76KNgne74Sxx8E0D4Zi02ATqCCx8yN8VqgekNpOKQLycN8ryU5-ZpELJ4Cecw-txK5R9vItqfO3179uJ_iM_Ifm88HIhBf_TplBwE2E_D1sO8JLXlfGVeQVSzVK_tv3sHmbPurw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fa9swED-yBMpeunbt1uxP57LRh4GD_8i2DHsJSdN0XdOttGtfhpBkGUpoHLIESp_2HfYN-0l2J8fJUsZgezE2Phn5Tnf3O-l0AngXUkUUnuVuqkLmMhb4rvKNdrX2uZQm8nO7PfpkEPcv2Mer6KoGH6q9MGV9iMWEG2mGtdek4OMs_03JdZFdtwgQRI-gwWKEvgSJzhbFo_w4sbN7aApQ59ErzouTUh7Psu2KO2oQZ2__hDVXoav1Pb0n8K3qdZlyMmzNpqql7x4UdPzf39qA9TkoddrlKNqEmhk9hbWT-bL7FvA2Wid0ehN8LG6kU-QO4kZHUiNtr_c_fjrSWZaFdsotMdtw0Ts47_Td-ZELrmZhGJFt1EEWm1irQLHMMM29NDfKC1QgVUhrgpIrlGCemDROMB5RktMhfx6Tocqi8BnUR8XI7ICTUbG7DP1_KvGlpFDJi7kJkSxlKfOb8LbivBiXlTVEFZEQE4RlQhP2rVAWJHIypFy0JBKXg0PBur3zL0nwVSDhXiU1gRpCyx5yZIrZdwpuMBDHaDltwvNSnIuvIWDxUs6x9XsrlL_0RHROu0f27sW_EL-Btc_dnvh0NDh-CY8DOkzDJsO8gvp0MjOvEdJM1a4dub8A2uPtXg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Adenocarcinoma+of+the+anal+canal+-+a+systematic+review&rft.jtitle=Colorectal+disease&rft.au=Anwar%2C+S&rft.au=Welbourn%2C+H&rft.au=Hill%2C+J&rft.au=Sebag-Montefiore%2C+D&rft.date=2013-12-01&rft.eissn=1463-1318&rft.volume=15&rft.issue=12&rft.spage=1481&rft.epage=1488&rft_id=info:doi/10.1111%2Fcodi.12325&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1462-8910&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1462-8910&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1462-8910&client=summon