Effects of 3‐ and 5‐Year Treatment With Risedronate on Bone Mineralization Density Distribution in Triple Biopsies of the Iliac Crest in Postmenopausal Women

• Published in: Journal of bone and mineral research Vol. 21; no. 7; pp. 1106 - 1112
• Main Authors: Zoehrer, Ruth, Roschger, Paul, Paschalis, Eleftherios P, Hofstaetter, Jochen G, Durchschlag, Erich, Fratzl, Peter, Phipps, Roger, Klaushofer, Klaus
• Format: Journal Article
• Language: English
• Published: Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01.07.2006; American Society for Bone and Mineral Research
• Subjects: Biological and medical sciences; Biopsy; Bone Density - drug effects; Bone Density Conservation Agents - administration & dosage; bone mineralization density distribution; Calcification, Physiologic - drug effects; Etidronic Acid - administration & dosage; Etidronic Acid - analogs & derivatives; Female; Follow-Up Studies; Fractures, Bone - prevention & control; Fundamental and applied biological sciences. Psychology; Humans; long‐term risedronate treatment; Osteoporosis, Postmenopausal - drug therapy; Osteoporosis, Postmenopausal - pathology; postmenopausal osteoporosis; quantitative backscattered electron imaging; Risedronate Sodium; Risk Factors; Skeleton and joints; Time Factors; triple biopsies; Vertebrates: osteoarticular system, musculoskeletal system; Diseases of the osteoarticular system; Diphosphonic acid derivatives; Bisphosphonates; Density; Long term; postmenopausal osteoporosis; Osteoarticular system; Osteoporosis; Vertebrata; bone mineralization density distribution; Mammalia; Treatment; quantitative backscattered electron imaging; Risedronic acid; Biopsy; Mineralization; Imaging; Distribution; Postmenopause; Female; triple biopsies; Bone; Iliac crest; long-term risedronate treatment

Long‐term effects of risedronate on bone mineralization density distribution in triple transiliac crest biopsies of osteoporotic women were evaluated. In this double‐blinded study, 3‐ and 5‐year treatment with risedronate increased the degree and homogeneity of mineralization without producing hyper...