Interferons, interferon-like cytokines, and their receptors

• Published in: Immunological reviews Vol. 202; no. 1; pp. 8 - 32
• Main Authors: Pestka, Sidney, Krause, Christopher D., Walter, Mark R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK; Malden, USA Munksgaard International Publishers 01.12.2004
• Subjects: Animals; Evolution, Molecular; Hepatitis, Viral, Human - drug therapy; Humans; Interferon Type I - physiology; Interferon-alpha - physiology; Interferon-gamma - physiology; Interferons - genetics; Interferons - isolation & purification; Interferons - physiology; Interferons - therapeutic use; Molecular Structure; Multiple Sclerosis, Relapsing-Remitting - drug therapy; Protein Structure, Tertiary; Receptors, Interferon - physiology; Signal Transduction - physiology

Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of many other cytokines and growth factors. Nevertheless, understanding the functions of the multitude of human IFNs and IFN‐l...