Noninvasive Imaging of Ethanol-Induced Developmental Defects in Zebrafish Embryos Using Optical Coherence Tomography
In this article, we report the use of optical coherence tomography for noninvasive cross‐sectional real‐time imaging of ethanol‐induced developmental defects in zebrafish embryos larvae. For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), mal...
Saved in:
| Published in | Birth defects research. Part B. Developmental and reproductive toxicology Vol. 95; no. 1; pp. 7 - 11 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.02.2012
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | In this article, we report the use of optical coherence tomography for noninvasive cross‐sectional real‐time imaging of ethanol‐induced developmental defects in zebrafish embryos larvae. For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), malformation of the notochord and ataxia arising due to the toxic effects of ethanol were observed in OCT images from 3 days post fertilization onwards. The results suggest that OCT could be a valuable tool for noninvasive assessment of birth defects in small animal systems. |
|---|---|
| AbstractList | In this article, we report the use of optical coherence tomography for noninvasive cross-sectional real-time imaging of ethanol-induced developmental defects in zebrafish embryos larvae. For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), malformation of the notochord and ataxia arising due to the toxic effects of ethanol were observed in OCT images from 3 days post fertilization onwards. The results suggest that OCT could be a valuable tool for noninvasive assessment of birth defects in small animal systems. Abstract In this article, we report the use of optical coherence tomography for noninvasive cross‐sectional real‐time imaging of ethanol‐induced developmental defects in zebrafish embryos larvae. For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), malformation of the notochord and ataxia arising due to the toxic effects of ethanol were observed in OCT images from 3 days post fertilization onwards. The results suggest that OCT could be a valuable tool for noninvasive assessment of birth defects in small animal systems. |
| Author | Divakar Rao, K. Gupta, P. K. Upadhyaya, Piyush Sharma, Mrinalini |
| Author_xml | – sequence: 1 givenname: K. surname: Divakar Rao fullname: Divakar Rao, K. email: kdivakar@rrcat.gov.in organization: Laser Biomedical Applications & Instrumentation Division, Raja Ramanna Centre for Advanced Technology, Indore, India – sequence: 2 givenname: Piyush surname: Upadhyaya fullname: Upadhyaya, Piyush – sequence: 3 givenname: Mrinalini surname: Sharma fullname: Sharma, Mrinalini – sequence: 4 givenname: P. K. surname: Gupta fullname: Gupta, P. K. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21922639$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kMtu2zAQRYkiQfNoN_2AQsuigBK-JJrLxnYdB0ECFC4SdEOQ1MhmK5EKKbv130eOEy-7mhng3APMPUNHPnhA6BPBFwRjemmqaC4oZoy-Q6ek4DSXgpOjw87YCTpL6ffAMiFG79EJJZLSkslT1N8F7_xGJ7eBbN7qpfPLLNTZtF9pH5p87qu1hSqbwAaa0LXge90MVw22T5nz2S8wUdcurbJpa-I2pOxn2jnuu97ZAR2HFUTwFrJFaMMy6m61_YCOa90k-Pg6z9Hi-3Qxvs5v72fz8bfb3PLhmVwXAFxUXFID2FCqeVUYURtRVgRLg2U1qgsraSG1BlpxYQtOaklsacp6RNk5-rLXdjE8rSH1qnXJQtNoD2GdFOEUl5gTRgb06x61MaQUoVZddK2OW0Ww2pWsdiWrl5IH-POrd21aqA7oW6sDQPbAX9fA9j8qdTX5cfUmzfcZl3r4d8jo-EeVgolCPdzN1OPNRM6ub4Si7BlWh5lb |
| CitedBy_id | crossref_primary_10_1002_jbio_201200069 crossref_primary_10_1038_s41598_022_19483_z crossref_primary_10_1089_zeb_2017_1447 crossref_primary_10_1364_BOE_6_000297 crossref_primary_10_1364_BOE_390410 crossref_primary_10_1002_jbio_202200098 crossref_primary_10_3390_ijms24129833 crossref_primary_10_1007_s40010_015_0251_z crossref_primary_10_1117_1_JBO_21_5_050902 crossref_primary_10_1364_BOE_8_002359 crossref_primary_10_1364_BOE_455876 |
| Cites_doi | 10.1371/journal.pone.0009318 10.1006/dbio.1995.1265 10.1016/S0892-0362(02)00319-7 10.1016/j.ntt.2004.06.016 10.1167/iovs.05-0971 10.1364/OPEX.14.000736 10.1016/j.semcdb.2009.08.003 10.1364/OE.11.001650 10.1016/j.ntt.2006.02.001 10.1016/j.exer.2007.02.015 10.1002/bdra.20564 10.1002/jez.1401770107 10.1017/S0952523807070423 10.1016/j.ntt.2006.05.007 10.1242/dev.022426 10.1016/0892-0362(90)90094-S 10.1186/1741-7007-5-34 10.1016/j.mod.2003.07.005 10.1016/j.zemedi.2009.11.002 10.1002/jbio.200910032 10.1167/iovs.05-1611 10.1242/dev.01812 10.1037/0033-2909.90.3.564 10.1016/j.ntt.2004.06.011 10.1016/j.taap.2006.04.014 |
| ContentType | Journal Article |
| Copyright | 2011 Wiley‐Liss, Inc. 2011 Wiley-Liss, Inc. |
| Copyright_xml | – notice: 2011 Wiley‐Liss, Inc. – notice: 2011 Wiley-Liss, Inc. |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1002/bdrb.20332 |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health |
| EISSN | 1542-9741 |
| EndPage | 11 |
| ExternalDocumentID | 10_1002_bdrb_20332 21922639 BDRB20332 ark_67375_WNG_XJD9GHJ7_2 |
| Genre | article Journal Article |
| GroupedDBID | .GA .Y3 05W 10A 1L6 1OC 23N 31~ 4.4 51W 51X 52N 52O 52P 52S 52T 52W 52X 53G 5GY 5VS 6J9 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAEVG AAHHS AANLZ AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACPOU ACPRK ACSCC ACXBN ACXQS ADEOM ADIZJ ADMGS ADOZA ADZOD AEEZP AEIGN AEIMD AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AITYG AIURR AIWBW AJBDE ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZFZN BDRZF BRXPI BSCLL BY8 CO8 CS3 D-E D-F DCZOG DPXWK DR2 DRFUL DRSTM EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE G-S GNP GODZA HBH HF~ HGLYW HHY HHZ HVGLF IX1 KQQ LATKE LAW LEEKS LH4 LOXES LP6 LP7 LUTES LYRES MEWTI MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM OIG P2W P4D PQQKQ Q11 QB0 QRW ROL RWI RYL SUPJJ SV3 UB1 V2E W99 WIH WJL WQJ WRC WXSBR WYUIH XG1 XPP XV2 ZZTAW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c4332-a5ee47d492be0b22a4d5b7fb76d109b09d8f5c9259aae2d47c541f91c6b6f823 |
| IEDL.DBID | DR2 |
| ISSN | 1542-9733 |
| IngestDate | Fri Aug 16 22:57:33 EDT 2024 Fri Aug 23 01:33:44 EDT 2024 Sat Sep 28 08:01:51 EDT 2024 Sat Aug 24 00:59:44 EDT 2024 Wed Oct 30 09:52:22 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | developmental defects ethanol toxicity embryo/fetal physiology optical coherence tomography |
| Language | English |
| License | 2011 Wiley-Liss, Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4332-a5ee47d492be0b22a4d5b7fb76d109b09d8f5c9259aae2d47c541f91c6b6f823 |
| Notes | istex:EB6AA841FA47C48A1C5E4FE4E5459F369F21D1F9 ArticleID:BDRB20332 ark:/67375/WNG-XJD9GHJ7-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 21922639 |
| PQID | 1420604131 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_1420604131 crossref_primary_10_1002_bdrb_20332 pubmed_primary_21922639 wiley_primary_10_1002_bdrb_20332_BDRB20332 istex_primary_ark_67375_WNG_XJD9GHJ7_2 |
| PublicationCentury | 2000 |
| PublicationDate | February 2012 |
| PublicationDateYYYYMMDD | 2012-02-01 |
| PublicationDate_xml | – month: 02 year: 2012 text: February 2012 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Birth defects research. Part B. Developmental and reproductive toxicology |
| PublicationTitleAlternate | Birth Defects Res B |
| PublicationYear | 2012 |
| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
| References | Bilotta J, Barnetta JA, Hancocka L, Saszik S. 2004. Ethanol exposure alters zebrafish development: a novel model of fetal alcohol syndrome. Neurotoxicol Teratol 26:737-743. Clarke J. 2009. Live imaging of development in fish embryos. Semin Cell Dev Biol 20:942-946. Dahm R, Schonthaler HB, Soehn AS, et al. 2007. Development and adult morphology of the eye lens in the zebrafish. Exp Eye Res 85:74-89. Arenzana FJ, CarvanIII MJ, Aijón J, et al. 2006. Teratogenic effects of ethanol exposure on zebrafish visual system development. Neurotoxicol Teratol 28:342-348. Loucks EJ, Ahlgren SC. 2009. Deciphering the role of Shh signaling in axial defects produced by ethanol exposure. Birth Defects Res A Clin Mol Teratol 85:556-567. Zhao XC, Yee RW, Norcom E, et al. 2006. The zebrafish cornea: structure and development. Invest Ophthalmol Vis Sci 47:4341-4348. Driscoll CD, Streissguth AP, Riley EP. 1990. Prenatal alcohol exposure: comparability of effects in humans and animal models. Neurotoxicol Teratol 12:231-237. Kagemann L, Ishikawa H, Zou J, et al. 2008. Repeated, noninvasive, high resolution spectral domain optical coherence tomography imaging of zebrafish embryos. Mol Vis 14:2157-2170. Megason SG, Fraser SE. 2003. Digitizing life at the level of the cell: high-performance laser-scanning microscopy and image analysis for in toto imaging of development. Mech Dev 120:1407-1420. Tilton F, Du JKL, Vue M, Alzarban N, Tanguay RL. 2006. Dithiocarbamates have a common toxic effect on zebrafish body axis formation. Toxicol Appl Pharmacol 216:55-68 Amsterdam A, Lin S, Hopkins N. 1995. The Aequorea victoria green fluorescent protein can be used as a reporter in live zebrafish embryos. Dev Biol 171:123-129. Rao KD, Alex A, Verma Y, et al. 2009. Real-time in vivo imaging of adult Zebrafish brain using optical coherence tomography. J Biophotonics 2:288-291. Reimers MJ, Du JKL, Periera CB, et al. 2006. Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants. Neurotoxicol Teratol 28:497-508. Kasyap B, Frederickson LC, Stenkamp DL. 2007. Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos. Vis Neurosci 24:409-421. Rao KD, Verma Y, Patel HS, Gupta PK. 2006. Noninvasive ophthalmic imaging of adult zebrafish eye using optical coherence tomography. Current Sci 90:1506-1510. Bilotta J, Saszik S, Givin CM, et al. 2002. Effects of embryonic exposure to ethanol on zebrafish visual function. Neurotoxicol Teratol 24:759-766. Jenkins MW, Rothenberg F, Roy D, et al. 2006. 4D embryonic cardiography using gated optical coherence tomography. Opt Express 14:736-748. Laale HW. 1971. Ethanol induced notochord and spinal cord duplications in the embryo of the zebrafish Brachydanio rerio. J Exp Zool 177:51-64. Yang VXD, Gordon M, Sung-Yue E, et al. 2003. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): imaging in vivo cardiac dynamics of Xenopus laevis. Opt Express 11:1650-1658. Carvan III MJ, Loucks E, Weber DN, Williams FE. 2004. Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis. Neurotoxicol Teratol 26:757-768. Matsui JI, Egana AL, Sponholtz TR, Adolph AR, Dowling JE. 2006. Effects of ethanol on photoreceptors and visual function in developing zebrafish. Invest Ophthalmol Vis Sci 47:4589-4597. Huisken J, Stainier DYR. 2009. Selective plane illumination microscopy techniques in developmental biology. Development 136:1963-1975. Chen H, Yuh C, Wu KK. 2010. Nestin is essential for zebrafish brain and eye development through control of progenitor cell apoptosis. PLoS ONE 5:e9318. Abel EL. 1981.Behavioral teratology of alcohol. Psychol Bull 90:564-581. Stratton K, Howe C, Battaglia F. 1996. Fetal alcohol syndrome: diagnosis, epidemiology, prevention, and treatment. Washington, DC: National Academy Press. Stemple DL. 2005. Structure and function of the notochord: an essential organ for chordate development. Development 132:2503-2512. Bryson-Richardson RJ, Berger S, Schilling TF, et al. 2007. FishNet: an online database of zebrafish anatomy. BMC Biol 5:34. Fercher AF. 2010. Optical coherence tomography-development,principles, applications. Z Med Phys 20:251-276. 2006; 90 1981; 90 2009; 85 1990; 12 2009; 20 2005; 132 2004; 26 2006; 14 2008; 14 1996 2000; 1 2006; 216 1995; 171 2009; 136 2003; 11 2010; 20 2006; 28 2002; 24 2006; 47 2007; 5 1971; 177 2007; 85 2009; 2 2010; 5 2007; 24 2003; 120 e_1_2_6_10_1 Kasyap B (e_1_2_6_18_1) 2007; 24 e_1_2_6_30_1 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_15_1 e_1_2_6_16_1 e_1_2_6_21_1 e_1_2_6_20_1 Rao KD (e_1_2_6_23_1) 2006; 90 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_6_1 Kagemann L (e_1_2_6_17_1) 2008; 14 Boppart SA (e_1_2_6_7_1) 2000 e_1_2_6_25_1 Stratton K (e_1_2_6_27_1) 1996 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_29_1 e_1_2_6_28_1 e_1_2_6_26_1 |
| References_xml | – volume: 12 start-page: 231 year: 1990 end-page: 237 article-title: Prenatal alcohol exposure: comparability of effects in humans and animal models publication-title: Neurotoxicol Teratol – volume: 132 start-page: 2503 year: 2005 end-page: 2512 article-title: Structure and function of the notochord: an essential organ for chordate development publication-title: Development – volume: 14 start-page: 736 year: 2006 end-page: 748 article-title: 4D embryonic cardiography using gated optical coherence tomography publication-title: Opt Express – volume: 5 start-page: e9318 year: 2010 article-title: Nestin is essential for zebrafish brain and eye development through control of progenitor cell apoptosis publication-title: PLoS ONE – volume: 1 start-page: 217 year: 2000 end-page: 233 – volume: 216 start-page: 55 year: 2006 end-page: 68 article-title: Dithiocarbamates have a common toxic effect on zebrafish body axis formation publication-title: Toxicol Appl Pharmacol – volume: 47 start-page: 4341 year: 2006 end-page: 4348 article-title: The zebrafish cornea: structure and development publication-title: Invest Ophthalmol Vis Sci – volume: 136 start-page: 1963 year: 2009 end-page: 1975 article-title: Selective plane illumination microscopy techniques in developmental biology publication-title: Development – year: 1996 – volume: 26 start-page: 757 year: 2004 end-page: 768 article-title: Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis publication-title: Neurotoxicol Teratol – volume: 14 start-page: 2157 year: 2008 end-page: 2170 article-title: Repeated, noninvasive, high resolution spectral domain optical coherence tomography imaging of zebrafish embryos publication-title: Mol Vis – volume: 177 start-page: 51 year: 1971 end-page: 64 article-title: Ethanol induced notochord and spinal cord duplications in the embryo of the zebrafish publication-title: J Exp Zool – volume: 26 start-page: 737 year: 2004 end-page: 743 article-title: Ethanol exposure alters zebrafish development: a novel model of fetal alcohol syndrome publication-title: Neurotoxicol Teratol – volume: 90 start-page: 1506 year: 2006 end-page: 1510 article-title: Noninvasive ophthalmic imaging of adult zebrafish eye using optical coherence tomography publication-title: Current Sci – volume: 5 start-page: 34 year: 2007 article-title: FishNet: an online database of zebrafish anatomy publication-title: BMC Biol – volume: 85 start-page: 74 year: 2007 end-page: 89 article-title: Development and adult morphology of the eye lens in the zebrafish publication-title: Exp Eye Res – volume: 20 start-page: 942 year: 2009 end-page: 946 article-title: Live imaging of development in fish embryos publication-title: Semin Cell Dev Biol – volume: 171 start-page: 123 year: 1995 end-page: 129 article-title: The green fluorescent protein can be used as a reporter in live zebrafish embryos publication-title: Dev Biol – volume: 28 start-page: 497 year: 2006 end-page: 508 article-title: Ethanol‐dependent toxicity in zebrafish is partially attenuated by antioxidants publication-title: Neurotoxicol Teratol – volume: 28 start-page: 342 year: 2006 end-page: 348 article-title: Teratogenic effects of ethanol exposure on zebrafish visual system development publication-title: Neurotoxicol Teratol – volume: 20 start-page: 251 year: 2010 end-page: 276 article-title: Optical coherence tomography–development,principles, applications publication-title: Z Med Phys – volume: 24 start-page: 409 year: 2007 end-page: 421 article-title: Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos publication-title: Vis Neurosci – volume: 120 start-page: 1407 year: 2003 end-page: 1420 article-title: Digitizing life at the level of the cell: high‐performance laser‐scanning microscopy and image analysis for in toto imaging of development publication-title: Mech Dev – volume: 85 start-page: 556 year: 2009 end-page: 567 article-title: Deciphering the role of Shh signaling in axial defects produced by ethanol exposure publication-title: Birth Defects Res A Clin Mol Teratol – volume: 24 start-page: 759 year: 2002 end-page: 766 article-title: Effects of embryonic exposure to ethanol on zebrafish visual function publication-title: Neurotoxicol Teratol – volume: 90 start-page: 564 year: 1981 end-page: 581 article-title: Behavioral teratology of alcohol publication-title: Psychol Bull – volume: 47 start-page: 4589 year: 2006 end-page: 4597 article-title: Effects of ethanol on photoreceptors and visual function in developing zebrafish publication-title: Invest Ophthalmol Vis Sci – volume: 2 start-page: 288 year: 2009 end-page: 291 article-title: Real‐time in vivo imaging of adult Zebrafish brain using optical coherence tomography publication-title: J Biophotonics – volume: 11 start-page: 1650 year: 2003 end-page: 1658 article-title: High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): imaging in vivo cardiac dynamics of publication-title: Opt Express – volume: 90 start-page: 1506 year: 2006 ident: e_1_2_6_23_1 article-title: Noninvasive ophthalmic imaging of adult zebrafish eye using optical coherence tomography publication-title: Current Sci contributor: fullname: Rao KD – ident: e_1_2_6_10_1 doi: 10.1371/journal.pone.0009318 – ident: e_1_2_6_3_1 doi: 10.1006/dbio.1995.1265 – ident: e_1_2_6_5_1 doi: 10.1016/S0892-0362(02)00319-7 – ident: e_1_2_6_9_1 doi: 10.1016/j.ntt.2004.06.016 – ident: e_1_2_6_21_1 doi: 10.1167/iovs.05-0971 – ident: e_1_2_6_16_1 doi: 10.1364/OPEX.14.000736 – ident: e_1_2_6_11_1 doi: 10.1016/j.semcdb.2009.08.003 – ident: e_1_2_6_29_1 doi: 10.1364/OE.11.001650 – ident: e_1_2_6_4_1 doi: 10.1016/j.ntt.2006.02.001 – ident: e_1_2_6_12_1 doi: 10.1016/j.exer.2007.02.015 – ident: e_1_2_6_20_1 doi: 10.1002/bdra.20564 – start-page: 217 volume-title: Methods in molecular biology 135 developmental biology protocols year: 2000 ident: e_1_2_6_7_1 contributor: fullname: Boppart SA – ident: e_1_2_6_19_1 doi: 10.1002/jez.1401770107 – volume: 24 start-page: 409 year: 2007 ident: e_1_2_6_18_1 article-title: Mechanisms for persistent microphthalmia following ethanol exposure during retinal neurogenesis in zebrafish embryos publication-title: Vis Neurosci doi: 10.1017/S0952523807070423 contributor: fullname: Kasyap B – ident: e_1_2_6_25_1 doi: 10.1016/j.ntt.2006.05.007 – volume-title: Fetal alcohol syndrome: diagnosis, epidemiology, prevention, and treatment year: 1996 ident: e_1_2_6_27_1 contributor: fullname: Stratton K – ident: e_1_2_6_15_1 doi: 10.1242/dev.022426 – volume: 14 start-page: 2157 year: 2008 ident: e_1_2_6_17_1 article-title: Repeated, noninvasive, high resolution spectral domain optical coherence tomography imaging of zebrafish embryos publication-title: Mol Vis contributor: fullname: Kagemann L – ident: e_1_2_6_13_1 doi: 10.1016/0892-0362(90)90094-S – ident: e_1_2_6_8_1 doi: 10.1186/1741-7007-5-34 – ident: e_1_2_6_22_1 doi: 10.1016/j.mod.2003.07.005 – ident: e_1_2_6_14_1 doi: 10.1016/j.zemedi.2009.11.002 – ident: e_1_2_6_24_1 doi: 10.1002/jbio.200910032 – ident: e_1_2_6_30_1 doi: 10.1167/iovs.05-1611 – ident: e_1_2_6_26_1 doi: 10.1242/dev.01812 – ident: e_1_2_6_2_1 doi: 10.1037/0033-2909.90.3.564 – ident: e_1_2_6_6_1 doi: 10.1016/j.ntt.2004.06.011 – ident: e_1_2_6_28_1 doi: 10.1016/j.taap.2006.04.014 |
| SSID | ssj0023778 |
| Score | 2.074962 |
| Snippet | In this article, we report the use of optical coherence tomography for noninvasive cross‐sectional real‐time imaging of ethanol‐induced developmental defects... In this article, we report the use of optical coherence tomography for noninvasive cross-sectional real-time imaging of ethanol-induced developmental defects... Abstract In this article, we report the use of optical coherence tomography for noninvasive cross‐sectional real‐time imaging of ethanol‐induced developmental... |
| SourceID | proquest crossref pubmed wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 7 |
| SubjectTerms | Animals developmental defects Embryo, Nonmammalian - abnormalities Embryo, Nonmammalian - drug effects Embryo, Nonmammalian - pathology embryo/fetal physiology Embryonic Development - drug effects Ethanol - toxicity Eye - drug effects Eye - pathology Female Imaging, Three-Dimensional Male optical coherence tomography Survival Analysis Tail - abnormalities Tomography, Optical Coherence - methods Zebrafish - embryology |
| Title | Noninvasive Imaging of Ethanol-Induced Developmental Defects in Zebrafish Embryos Using Optical Coherence Tomography |
| URI | https://api.istex.fr/ark:/67375/WNG-XJD9GHJ7-2/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fbdrb.20332 https://www.ncbi.nlm.nih.gov/pubmed/21922639 https://search.proquest.com/docview/1420604131 |
| Volume | 95 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1baxQxFA6lvgji_bJeSkTxQZh2J8lMJtAX2912XXCFsuIiSMjJBUvdmbKXoj71J_gb_SXmsju1IoK-zUMmJDknJ-ecfOcLQs-LUmlqCpqVBsqMVQKyyhrIutprQCVsLkyod34zKgfv2HBSTDbQ7roWJvFDtAm3sDOivQ4bXMF854I0FMwMfHxHaTDAOeUBz9U7armjCOXRDHsXgWSCU9pyk5Kdi18vnUZXwsJ--ZOredlzjUfPwQ30cT3ohDg52V4uYFt_-43P8X9ndRNdX_mk-FVSoltow9a30bWU0MOpTukOOhuFxO2ZCnB3_HoaHzfCjcP9kHtvPv84_x5eAdHW4F9wSL7Xno2AEXxc4w_hktodzz_h_hRmX5s5joAF_PY0JtRxKBWJxYd43ExXVNp30figP94fZKtHGzIdqNAyVVjLuGGCgO0CIYqZArgDXpq8K6ArTOUKLXzUpZQlhnFdsNyJXJdQuorQe2izbmr7AGHigBEg3Md0lClRQS4cE5V2ilpvmEgHPVvLTp4mag6ZSJiJDMso4zJ20Iso1raJmp0EMBsv5PvRoZwMe-JwMOTSN3y6lrv0Wyzcm6jaNsu5j45IoBjKad5B95NCtL15g-8dWCo66GUU619GIvd6R3vx6-G_NH6ErnonjSSk-GO0uZgt7RPvCC1gKyr8T-3VBHc |
| link.rule.ids | 315,783,787,1378,27936,27937,46306,46730 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jb9QwFLZQewAJsS_DagTigJR2YjtxfKTMtNOhHaRqEKNeLK-iKpNUs1TAiZ_Ab-SX4GdPU4oQEtxycKzEb_Hz8_e-h9CLolSG2oJmpdVlxiqhs8pZnXVN0IBKuFxYqHfeH5WD92w4KSYrbA7UwiR-iDbhBpYR_TUYOCSkN89ZQ7Wd6XDAozR44PVg7xQ6N_QOWvYoQnl0xCFIIJnglLbspGTz_N0L-9E6LO3nPwWbF2PXuPlsX08dVueRsxAwJ8cby4XeMF9_Y3T87_-6ga6twlL8OunRTXTJ1bfQ1ZTTw6lU6TY6HUHu9lQB4h3vTmN_I9x43If0e_Ppx7fv0AjEOIt_gSKFWXsuYkbwUY0P4Z7aH80_4v5Uz740cxwxC_jdScypY6gWifWHeNxMV2zad9B4uz9-M8hWfRsyA2xomSqcY9wyQbTrakIUs4XmXvPS5l2hu8JWvjAiHLyUcsQybgqWe5GbUpe-IvQuWqub2t1HmHjNiCY8HOsoU6LSufBMVMYr6oJvIh30_Ex48iSxc8jEw0wkLKOMy9hBL6Nc2yFqdgx4Nl7ID6MdORn2xM5gyGUY-OxM8DJYGVydqNo1y3k4IBFgGcpp3kH3kka0swWfH2JYKjroVZTrX75EbvUOtuLTg38Z_BRdHoz39-Te7ujtQ3QlxGwkAccfobXFbOkeh7hooZ9E7f8JG-oIjw |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bixMxFD4suyCCeL_Ua0TxQZjdTpKZTMAX17bbrVplqWwRJOSKy9qZ0suiPvkT_I3-EpNMO-uKCPo2D5mQ5JycfOfknC8Aj7NcamIykuRG5QktuEoKa1TS1l4DCm5TbkK98-th3n9HB-NsvAHP1rUwNT9EE3ALOyPa67DBp8btnJKGKjNT3r8jxBvgLZp76Bsg0UFDHoUJi3bYYwSccEZIQ06Kd07_PXMcbYWV_fwnrHkWusazp3cJPqxHXaecHG8vF2pbf_2N0PF_p3UZLq5AKXpea9EV2LDlVbhQR_RQXah0DU6GIXJ7IkO-O9qfxNeNUOVQNwTfq08_vn0Pz4Boa9AviUi-146NGSPoqETvwy21O5p_RN2Jmn2p5ihmLKA30xhRR6FWJFYfolE1WXFpX4dRrzt60U9WrzYkOnChJTKzljJDOVa2rTCW1GSKOcVyk7a5anNTuExz73ZJabGhTGc0dTzVucpdgckN2Cyr0t4ChJ2iWGHmnTpCJS9Uyh3lhXaSWG-ZcAserWUnpjU3h6hZmLEIyyjiMrbgSRRr00TOjkM2G8vE4XBPjAcdvtcfMOEbPlzLXfg9Fi5OZGmr5dy7RzhwDKUkbcHNWiGa3rzF9wiW8BY8jWL9y0jEbudgN37d_pfGD-Dc205PvNofvrwD5z1gw3XW-F3YXMyW9p4HRQt1P-r-TwO0Bz4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Noninvasive+imaging+of+ethanol-induced+developmental+defects+in+zebrafish+embryos+using+optical+coherence+tomography&rft.jtitle=Birth+defects+research.+Part+B.+Developmental+and+reproductive+toxicology&rft.au=Divakar+Rao%2C+K&rft.au=Upadhyaya%2C+Piyush&rft.au=Sharma%2C+Mrinalini&rft.au=Gupta%2C+P+K&rft.date=2012-02-01&rft.eissn=1542-9741&rft.volume=95&rft.issue=1&rft.spage=7&rft.epage=11&rft_id=info:doi/10.1002%2Fbdrb.20332&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1542-9733&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1542-9733&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1542-9733&client=summon |