HLA-A-B-C-DRB1-DQB1 phased haplotypes in 124 Nigerian families indicate extreme HLA diversity and low linkage disequilibrium in Central-West Africa

• Published in: Tissue antigens Vol. 86; no. 4; pp. 285 - 292
• Main Authors: Testi, M., Battarra, M., Lucarelli, G., Isgro, A., Morrone, A., Akinyanju, O., Wakama, T., Nunes, J. M., Andreani, M., Sanchez-Mazas, A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2015
• Subjects: African peopling history; Alleles; anthropology; Family; family data; Gene Expression; Gene Frequency; Genetic Variation; Genetics, Population; Haplotypes; Histocompatibility Testing; HLA haplotypes; HLA-A Antigens - genetics; HLA-A Antigens - immunology; HLA-B Antigens - genetics; HLA-B Antigens - immunology; HLA-C Antigens - genetics; HLA-C Antigens - immunology; HLA-DQ beta-Chains - genetics; HLA-DQ beta-Chains - immunology; HLA-DRB1 Chains - genetics; HLA-DRB1 Chains - immunology; Humans; Linkage Disequilibrium; malaria resistance; Nigeria; Nigerian population; Pedigree; population genetics; Nigeria; African peopling history; population genetics; anthropology; Nigerian population; HLA haplotypes; family data; malaria resistance; linkage disequilibrium

The simultaneous typing of five‐HLA loci at high resolution and the availability of pedigree data allowed us to characterize extended five‐locus phased haplotypes in 124 Nigerian families and to compare the observed frequencies with those expected by an expectation–maximization algorithm for unphase...