Diastolic Blood Pressure and Mortality in the Elderly With Cardiovascular Disease

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 50; no. 1; pp. 172 - 180
• Main Authors: Protogerou, Athanase D., Safar, Michel E., Iaria, Pierre, Safar, Hélène, Le Dudal, Katia, Filipovsky, Jan, Henry, Olivier, Ducimetière, Pierre, Blacher, Jacques
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.07.2007; Hagerstown, MD Lippincott
• Subjects: Aged; Aged, 80 and over; Aging; Arterial hypertension. Arterial hypotension; Arteries - physiopathology; Biological and medical sciences; Blood and lymphatic vessels; Blood Flow Velocity; Blood Pressure; Cardiology. Vascular system; Cardiovascular Diseases - mortality; Cardiovascular Diseases - physiopathology; Cause of Death; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Cohort Studies; Echocardiography; Elasticity; Female; Fundamental and applied biological sciences. Psychology; Heart - physiopathology; Hemodynamics. Rheology; Humans; Kaplan-Meier Estimate; Male; Medical sciences; Predictive Value of Tests; Proportional Hazards Models; Pulse; Vascular Resistance; Vertebrates: cardiovascular system; Human; arterial stiffness; Systolic pressure; Systolic hypertension; Diastolic pressure; Prognosis; Mortality; Cardiovascular disease; Survival; pressure wave reflections; Treatment; diastolic blood pressure; Risk factor; Antihypertensive agent; Aorta; Arterial pressure; Blood pressure; Stiffness; total peripheral resistance; Left ventricle performance; Elderly; Ultrasound

Isolated systolic hypertension is predominantly observed in the elderly because of increased arterial stiffness. Aggressive treatment leads to excessive lowering of diastolic blood pressure and favors the presence of a J-shaped curve association with mortality. We investigated whether, in the elderl...