Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in nutmeg‐based plant food supplements

• Published in: Journal of applied toxicology Vol. 37; no. 10; pp. 1254 - 1264
• Main Authors: Al‐Malahmeh, Amer J., Alajlouni, Abdalmajeed M., Ning, Jia, Wesseling, Sebastiaan, Vervoort, Jacques, Rietjens, Ivonne M. C. M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.10.2017
• Subjects: Alkenylbenzenes; Benzene - toxicity; Body weight; Carcinogens; Carcinogens - toxicity; Combined risk assessment; Dietary Supplements; Dioxins; DNA Damage - drug effects; Dose-Response Relationship, Drug; Equivalence; Exposure; Food Contamination - analysis; Genotoxicity; Humans; margin of exposure (MOE); Markets; Myristica fragrans - chemistry; Nutmeg; Nutmeg-based PFS; plant food supplement (PFS); Risk Assessment; Risk management; Safrole; toxic equivalency factors (TEFs); combined risk assessment; nutmeg-based PFS; plant food supplement (PFS); alkenylbenzenes; margin of exposure (MOE); toxic equivalency factors (TEFs)

A risk assessment of nutmeg‐based plant food supplements (PFS) containing different alkenylbenzenes was performed based on the alkenylbenzene levels quantified in a series of PFS collected via the online market. The estimated daily intake (EDI) of the alkenylbenzenes amounted to 0.3 to 312 μg kg−1 b...