Dendritic cells: Understanding immunogenicity

• Published in: European journal of immunology Vol. 37; no. S1; pp. 53 - 60
• Main Author: Steinman, Ralph M
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag 01.11.2007; WILEY‐VCH Verlag
• Subjects: Adjuvants; Animals; Antigen presentation; Antigen Presentation - immunology; Dendritic cells; Dendritic Cells - immunology; Humans; Immune Tolerance; Immunogenicity; Langerhans cells

The impetus for the discovery of dendritic cells in 1972 was to understand immunogenicity, the capacity of an antigenic substance to provoke immunity. During experiments to characterize "accessory" cells that enhanced immunity, we spotted unusual stellate cells in mouse spleen. They had a...