Interleukin-1β-induced anorexia is reversed by ghrelin

• Published in: Peptides (New York, N.Y. : 1980) Vol. 27; no. 12; pp. 3220 - 3225
• Main Authors: Gonzalez, Patricia Verónica, Cragnolini, Andrea Beatriz, Schiöth, Helgi Birgir, Scimonelli, Teresa Nieves
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2006; Elsevier Science
• Subjects: Animals; Anorexia - etiology; Anorexia - prevention & control; Biological and medical sciences; Central nervous system; Food intake; Fundamental and applied biological sciences. Psychology; Ghrelin; Ghrelin - physiology; IL-1β; Injections, Intraventricular; Interleukin-1beta - administration & dosage; Interleukin-1beta - physiology; Male; MEDICIN; MEDICINE; Rats; Rats, Wistar; Vertebrates: endocrinology; IL-1β; Ghrelin; Food intake; Central nervous system; Interleukin; Cytokine; Feeding

Interleukins, in particular interleukin-1β (IL-1β), reduce food intake after peripheral and central administration, which suggests that they contribute to anorexia during various infectious, neoplastic, and autoimmune diseases. On the other hand, ghrelin stimulates food intake by acting on the centr...