Synthesis of cellular fibronectin by rat liver fat-storing (Ito) cells: regulation by cytokines

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 103; no. 4; p. 1313
• Main Authors: Ramadori, G, Knittel, T, Odenthal, M, Schwögler, S, Neubauer, K, Meyer zum Büschenfelde, K H
• Format: Journal Article
• Language: English
• Published: United States 01.10.1992
• Subjects: Animals; Cells, Cultured; Female; Fibronectins - analysis; Fibronectins - biosynthesis; Interferon-gamma - pharmacology; Liver - cytology; Liver - metabolism; Rats; Rats, Inbred Strains; Transforming Growth Factor beta - pharmacology

Fibronectins are multifunctional extracellular matrix glycoproteins that seem to play a pacemaker role in liver fibrogenesis. The expression of cellular fibronectin by rat liver fat-storing cells in primary culture and their modulation by cytokines was studied. Cellular fibronectin was localized in...