Use of Cytomegalovirus Immune Globulin to Prevent Cytomegalovirus Disease in Renal-Transplant Recipients

• Published in: The New England journal of medicine Vol. 317; no. 17; pp. 1049 - 1054
• Main Authors: Snydman, David R, Werner, Barbara G, Heinze-Lacey, Beverly, Berardi, Victor P, Tilney, Nicholas L, Kirkman, Robert L, Milford, Edgar L, Cho, Sang I, Bush, Harry L, Levey, Andrew S, Levey, Raphael H, Strom, Terry B, Carpenter, Charles B, Harmon, William E, Zimmerman, Clarence E, Shapiro, Michael E, Steinman, Theodore, LoGerfo, Frank, Idelson, Beldon, Schröter, Gerhard P.J, Levin, Myron J, McIver, James, Leszczynski, Jeanne, Grady, George F
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 22.10.1987
• Subjects: Adult; Biological and medical sciences; Clinical Trials as Topic; Cytomegalovirus; Cytomegalovirus - immunology; Cytomegalovirus Infections - prevention & control; Female; Humans; Immunization, Passive - adverse effects; Immunization, Passive - methods; Immunoglobulins - administration & dosage; Infections; Investigations; Kidney Transplantation; Laboratories; Male; Medical sciences; Mycoses - prevention & control; Parasitic Diseases - prevention & control; Postoperative Complications - prevention & control; Prospective Studies; Random Allocation; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Transplants & implants; Virus; Human; Infection; Prevention; Cytomegalovirus; Urinary system disease; Herpesviridae; Surgery; Immunotherapy; Homotransplantation; Betaherpesvirinae; Kidney

We undertook a prospective randomized trial to examine whether an intravenous cytomegalovirus (CMV) immune globulin would prevent primary CMV disease in renal-transplant recipients. Fifty-nine CMV-seronegative patients who received kidneys from donors who had antibodies against CMV were assigned to...