Effects of Shock Waves on the Microcirculation in Critical Limb Ischemia (CLI) (8-Week Study)
Shock waves (SWs) are used to control and decrease pain in several clinical conditions (eg, painful elbow and shoulder, etc). This clinical effect may be due to cellular stunning of the tissues (particularly nervous components) in the area treated with SW. It may also be the consequence of unknown m...
Saved in:
Published in | Angiology Vol. 51; no. 8; pp. S69 - S78 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Thousand Oaks, CA
SAGE Publications
01.08.2000
SAGE PUBLICATIONS, INC |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Shock waves (SWs) are used to control and decrease pain in several clinical conditions (eg, painful elbow and shoulder, etc). This clinical effect may be due to cellular stunning of the tissues (particularly nervous components) in the area treated with SW. It may also be the consequence of unknown metabolic actions on tissues, which may include changes in cellular permeability and the liberation of proteins and mediators locally acting on pain and nerve endings. The aim of this study was to evaluate the reduction in pain and the microcirculation improvement induced by SWs treatment in an 8-week study in patients with chronic limb ischemia (CLI). Patients with CLI (15 with rest pain only and 15 with rest pain and limited distal necrosis) were included. The treatment was based on a 30-minute SWs session, three times weekly for 2 weeks. Clinical and microcirculatory evaluation were performed with laser Doppler PO 2 and PCO2 measurements. Pain was measured with an analogue scale line. A Minilith SL1 (Storz Medical, Switzerland) litotriptor was used. The parabolic reflector is coupled to the skin with a silicon water cushion. Focal pressure was adjusted between 6 and 70 Mpa in eight steps. The energy flux density was variable from 0.03 to 0.5 mJ/mm2. Focal diameter and distance were defined (depth of target within the patient's foot of about 70 mm). The coded intensity used in this study was between 6 and 8 and the application time was 20 min (at four impulses per second). Twenty-eight of the 30 patients with CLI (15 with rest pain only and 13 with necrosis) completed the study. The treatment was well tolerated. Blood pressure was unchanged after 8 weeks while the increase in laser Doppler flux was significant (p<0.05) (at all measurements after treatment). The ORACLE score at 1 and 8 weeks was decreased (p < 0.05). The same trend was observed with the analogue scale line for pain (p < 0.05). PO2 increased (p < 0.05) and PCO2 decreased (p < 0.05). Tibial pressure did not change. All patients observed an increase in their subjective pain-free walking distance. The improvement was still present after 8 weeks. In a separate subset of 37 patients (mean age 60 ±9 years; males) with CLI, a SWs dose-finding evaluation was performed. Flux changes were measured at the dorsum of the foot. Three treatment plans were used: (a) 20-minute SW treatment only once; (b) 20-minute SWs treatment every 2 days for 1 week; (c) 20 minutes every day for 1 week. Treatments were well tolerated. A different increase in flux was observed on the basis of different treatments. Flux vari ations generally indicated that increased SWs dosage was associated with proportional flux increase. Flux improvement was still present after 4 weeks. SWs treatment in CLI produced changes both in the microcirculation and on pain. These preliminary results are comforting and open new research options to be explored in the near future. |
---|---|
AbstractList | Shock waves (SWs) are used to control and decrease pain in several clinical conditions (e.g., painful elbow and shoulder, etc). This clinical effect may be due to cellular stunning of the tissues (particularly nervous components) in the area treated with SW. It may also be the consequence of unknown metabolic actions on tissues, which may include changes in cellular permeability and the liberation of proteins and mediators locally acting on pain and nerve endings. The aim of this study was to evaluate the reduction in pain and the microcirculation improvement induced by SWs treatment in an 8-week study in patients with chronic limb ischemia (CLI). Patients with CLI (15 with rest pain only and 15 with rest pain and limited distal necrosis) were included. The treatment was based on a 30-minute SWs session, three times weekly for 2 weeks. Clinical and microcirculatory evaluation were performed with laser Doppler Po2 and Pco2 measurements. Pain was measured with an analogue scale line. A Minilith SL1 (Storz Medical, Switzerland) litotriptor was used. The parabolic reflector is coupled to the skin with a silicon water cushion. Focal pressure was adjusted between 6 and 70 Mpa in eight steps. The energy flux density was variable from 0.03 to 0.5 mJ/mm2. Focal diameter and distance were defined (depth of target within the patient's foot of about 70 mm). The coded intensity used in this study was between 6 and 8 and the application time was 20 min (at four impulses per second). Twenty-eight of the 30 patients with CLI (15 with rest pain only and 13 with necrosis) completed the study. The treatment was well tolerated. Blood pressure was unchanged after 8 weeks while the increase in laser Doppler flux was significant (p<0.05) (at all measurements after treatment). The ORACLE score at 1 and 8 weeks was decreased (p<0.05). The same trend was observed with the analogue scale line for pain (p<0.05). PO2 increased (p<0.05) and Pco2 decreased (p<0.05). Tibial pressure did not change. All patients observed an increase in their subjective pain-free walking distance. The improvement was still present after 8 weeks. In a separate subset of 37 patients (mean age 60+/-9 years; males) with CLI, a SWs dose-finding evaluation was performed. Flux changes were measured at the dorsum of the foot. Three treatment plans were used: (a) 20-minute SW treatment only once; (b) 20-minute SWs treatment every 2 days for 1 week; (c) 20 minutes every day for 1 week. Treatments were well tolerated. A different increase in flux was observed on the basis of different treatments. Flux variations generally indicated that increased SWs dosage was associated with proportional flux increase. Flux improvement was still present after 4 weeks. SWs treatment in CLI produced changes both in the microcirculation and on pain. These preliminary results are comforting and open new research options to be explored in the near future. Shock waves (SWs) are used to control and decrease pain in several clinical conditions (eg, painful elbow and shoulder, etc). This clinical effect may be due to cellular stunning of the tissues (particularly nervous components) in the area treated with SW. It may also be the consequence of unknown metabolic actions on tissues, which may include changes in cellular permeability and the liberation of proteins and mediators locally acting on pain and nerve endings. The aim of this study was to evaluate the reduction in pain and the microcirculation improvement induced by SWs treatment in an 8-week study in patients with chronic limb ischemia (CLI). Patients with CLI (15 with rest pain only and 15 with rest pain and limited distal necrosis) were included. The treatment was based on a 30-minute SWs session, three times weekly for 2 weeks. Clinical and microcirculatory evaluation were performed with laser Doppler PO 2 and PCO2 measurements. Pain was measured with an analogue scale line. A Minilith SL1 (Storz Medical, Switzerland) litotriptor was used. The parabolic reflector is coupled to the skin with a silicon water cushion. Focal pressure was adjusted between 6 and 70 Mpa in eight steps. The energy flux density was variable from 0.03 to 0.5 mJ/mm2. Focal diameter and distance were defined (depth of target within the patient's foot of about 70 mm). The coded intensity used in this study was between 6 and 8 and the application time was 20 min (at four impulses per second). Twenty-eight of the 30 patients with CLI (15 with rest pain only and 13 with necrosis) completed the study. The treatment was well tolerated. Blood pressure was unchanged after 8 weeks while the increase in laser Doppler flux was significant (p<0.05) (at all measurements after treatment). The ORACLE score at 1 and 8 weeks was decreased (p < 0.05). The same trend was observed with the analogue scale line for pain (p < 0.05). PO2 increased (p < 0.05) and PCO2 decreased (p < 0.05). Tibial pressure did not change. All patients observed an increase in their subjective pain-free walking distance. The improvement was still present after 8 weeks. In a separate subset of 37 patients (mean age 60 ±9 years; males) with CLI, a SWs dose-finding evaluation was performed. Flux changes were measured at the dorsum of the foot. Three treatment plans were used: (a) 20-minute SW treatment only once; (b) 20-minute SWs treatment every 2 days for 1 week; (c) 20 minutes every day for 1 week. Treatments were well tolerated. A different increase in flux was observed on the basis of different treatments. Flux vari ations generally indicated that increased SWs dosage was associated with proportional flux increase. Flux improvement was still present after 4 weeks. SWs treatment in CLI produced changes both in the microcirculation and on pain. These preliminary results are comforting and open new research options to be explored in the near future. Shock waves (SWs) are used to control and decrease pain in several clinical conditions (e.g., painful elbow and shoulder, etc). This clinical effect may be due to cellular stunning of the tissues (particularly nervous components) in the area treated with SW. It may also be the consequence of unknown metabolic actions on tissues, which may include changes in cellular permeability and the liberation of proteins and mediators locally acting on pain and nerve endings. The aim of this study was to evaluate the reduction in pain and the microcirculation improvement induced by SWs treatment in an 8-week study in patients with chronic limb ischemia (CLI). Patients with CLI (15 with rest pain only and 15 with rest pain and limited distal necrosis) were included. The treatment was based on a 30-minute SWs session, three times weekly for 2 weeks. Clinical and microcirculatory evaluation were performed with laser Doppler Po2 and Pco2 measurements. Pain was measured with an analogue scale line. A Minilith SL1 (Storz Medical, Switzerland) litotriptor was used. The parabolic reflector is coupled to the skin with a silicon water cushion. Focal pressure was adjusted between 6 and 70 Mpa in eight steps. The energy flux density was variable from 0.03 to 0.5 mJ/mm2. Focal diameter and distance were defined (depth of target within the patient's foot of about 70 mm). The coded intensity used in this study was between 6 and 8 and the application time was 20 min (at four impulses per second). Twenty-eight of the 30 patients with CLI (15 with rest pain only and 13 with necrosis) completed the study. The treatment was well tolerated. Blood pressure was unchanged after 8 weeks while the increase in laser Doppler flux was significant (p<0.05) (at all measurements after treatment). The ORACLE score at 1 and 8 weeks was decreased (p<0.05). The same trend was observed with the analogue scale line for pain (p<0.05). PO2 increased (p<0.05) and Pco2 decreased (p<0.05). Tibial pressure did not change. All patients observed an increase in their subjective pain-free walking distance. The improvement was still present after 8 weeks. In a separate subset of 37 patients (mean age 60+/-9 years; males) with CLI, a SWs dose-finding evaluation was performed. Flux changes were measured at the dorsum of the foot. Three treatment plans were used: (a) 20-minute SW treatment only once; (b) 20-minute SWs treatment every 2 days for 1 week; (c) 20 minutes every day for 1 week. Treatments were well tolerated. A different increase in flux was observed on the basis of different treatments. Flux variations generally indicated that increased SWs dosage was associated with proportional flux increase. Flux improvement was still present after 4 weeks. SWs treatment in CLI produced changes both in the microcirculation and on pain. These preliminary results are comforting and open new research options to be explored in the near future. Shock waves (SWs) are used to control and decrease pain in several clinical conditions (eg, painful elbow and shoulder, etc). This clinical effect may be due to cellular stunning of the tissues (particularly nervous components) in the area treated with SW. It may also be the consequence of unknown metabolic actions on tissues, which may include changes in cellular permeability and the liberation of proteins and mediators locally acting on pain and nerve endings. The aim of this study was to evaluate the reduction in pain and the microcirculation improvement induced by SWs treatment in an 8-week study in patients with chronic limb ischemia (CLI). Patients with CLI (15 with rest pain only and 15 with rest pain and limited distal necrosis) were included. The treatment was based on a 30-minute SWs session, three times weekly for 2 weeks. Clinical and microcirculatory evaluation were performed with laser Doppler PO 2 and PCO 2 measurements. Pain was measured with an analogue scale line. A Minilith SL1 (Storz Medical, Switzerland) litotriptor was used. The parabolic reflector is coupled to the skin with a silicon water cushion. Focal pressure was adjusted between 6 and 70 Mpa in eight steps. The energy flux density was variable from 0.03 to 0.5 mJ/mm 2 . Focal diameter and distance were defined (depth of target within the patient's foot of about 70 mm). The coded intensity used in this study was between 6 and 8 and the application time was 20 min (at four impulses per second). Twenty-eight of the 30 patients with CLI (15 with rest pain only and 13 with necrosis) completed the study. The treatment was well tolerated. Blood pressure was unchanged after 8 weeks while the increase in laser Doppler flux was significant (p<0.05) (at all measurements after treatment). The ORACLE score at 1 and 8 weeks was decreased (p < 0.05). The same trend was observed with the analogue scale line for pain (p < 0.05). PO 2 increased (p < 0.05) and PCO 2 decreased (p < 0.05). Tibial pressure did not change. All patients observed an increase in their subjective pain-free walking distance. The improvement was still present after 8 weeks. In a separate subset of 37 patients (mean age 60 ±9 years; males) with CLI, a SWs dose-finding evaluation was performed. Flux changes were measured at the dorsum of the foot. Three treatment plans were used: (a) 20-minute SW treatment only once; (b) 20-minute SWs treatment every 2 days for 1 week; (c) 20 minutes every day for 1 week. Treatments were well tolerated. A different increase in flux was observed on the basis of different treatments. Flux vari ations generally indicated that increased SWs dosage was associated with proportional flux increase. Flux improvement was still present after 4 weeks. SWs treatment in CLI produced changes both in the microcirculation and on pain. These preliminary results are comforting and open new research options to be explored in the near future. |
Author | Cesarone, M.R. Ciccarelli, R. Nicolaides, A.N. Capodanno, S. Marlinghaus, E. Belcaro, G. Incandela, L. De Sanctis, M.T. Griffin, M. |
Author_xml | – sequence: 1 givenname: M.T. surname: De Sanctis fullname: De Sanctis, M.T. – sequence: 2 givenname: G. surname: Belcaro fullname: Belcaro, G. – sequence: 3 givenname: A.N. surname: Nicolaides fullname: Nicolaides, A.N. – sequence: 4 givenname: M.R. surname: Cesarone fullname: Cesarone, M.R. – sequence: 5 givenname: L. surname: Incandela fullname: Incandela, L. – sequence: 6 givenname: E. surname: Marlinghaus fullname: Marlinghaus, E. – sequence: 7 givenname: M. surname: Griffin fullname: Griffin, M. – sequence: 8 givenname: S. surname: Capodanno fullname: Capodanno, S. – sequence: 9 givenname: R. surname: Ciccarelli fullname: Ciccarelli, R. |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10959513$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kE1LxDAQhoMo7of-AQ8SPIh7qOarm-Yoy6oLKx5U9iQlTSdutB_atML-e7NUUBQ8DTM888687wjtVnUFCB1Rck6plBeEEM6pkqHGlJCEqB00pEqQiMZS7KLhFoi2xACNvH_puek-GlCiYhVTPkRPc2vBtB7XFt-va_OKV_oDQlvhdg341pmmNq4xXaFbF4auwrPGtc7oAi9dmeGFN2soncZns-Vigs-SaAXwiu_bLt9MDtCe1YWHw686Ro9X84fZTbS8u17MLpeREZy1EYicxolWiuWUK6WDK0E5ZUJnkuh8yq0lXBOTcJmpLIyFlRYgFoQnhFnDx-i0131r6vcOfJuWzhsoCl1B3flUMkamiZIBPPkFvtRdU4XfUsZEwmIhVIBYDwXv3jdg07fGlbrZpJSk2-TTv8mHpeMv5S4rIf-x0kcdgIse8PoZvs_-I_kJJt-JZA |
CitedBy_id | crossref_primary_10_3389_fbioe_2023_1197772 crossref_primary_10_1590_S1413_78522005000100008 crossref_primary_10_5397_cise_2016_19_1_20 crossref_primary_10_14474_ptrs_2014_3_2_142 crossref_primary_10_1016_j_burns_2009_11_012 crossref_primary_10_1016_j_jss_2019_06_077 crossref_primary_10_1002_biof_5520240132 crossref_primary_10_5535_arm_2012_36_5_665 crossref_primary_10_1177_000331970505600407 crossref_primary_10_5535_arm_21128 crossref_primary_10_1007_s10840_013_9845_z crossref_primary_10_1007_s12325_012_0038_4 crossref_primary_10_1272_jnms_81_19 crossref_primary_10_1097_MD_0000000000019085 crossref_primary_10_1016_j_jss_2009_12_011 |
Cites_doi | 10.1177/000331979905000903 10.1177/000331979804901103 10.1177/000331970005100802 10.1177/000331979804901001 |
ContentType | Journal Article |
Copyright | Copyright Westminster Publications, Inc. Aug 2000 |
Copyright_xml | – notice: Copyright Westminster Publications, Inc. Aug 2000 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH K9. M0S M1P PQEST PQQKQ PQUKI PRINS 7X8 |
DOI | 10.1177/000331970005100809 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest Medical Library ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest One Academic ProQuest Medical Library (Alumni) ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE CrossRef ProQuest One Academic Eastern Edition |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 7X7 name: ProQuest Health & Medical Collection url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1940-1574 |
EndPage | S78 |
ExternalDocumentID | 59285316 10_1177_000331970005100809 10959513 10.1177_000331970005100809 |
Genre | Clinical Trial Journal Article |
GroupedDBID | --- -MK -TM .2E .2F .2G .2J .2N .55 .GJ 01A 0R~ 1~K 23M 31R 31S 31U 31X 31Y 31Z 354 36B 39C 3V. 4.4 53G 54M 5GY 5RE 5VS 6J9 6PF 7X7 88E 8FI 8FJ 8R4 8R5 AABMB AABOD AACKU AACMV AACTG AADTT AADUE AAEWN AAGGD AAGMC AAJIQ AAJOX AAJPV AAKAS AAKGS AAMGE AANSI AAPEO AAQDB AAQGT AAQQT AAQXH AARDL AARIX AATAA AATBZ AAUAS AAWTL AAXOT AAYTG AAZBJ ABAWP ABCCA ABDWY ABEIX ABFWQ ABHKI ABHQH ABKRH ABLUO ABOCM ABPGX ABPNF ABQKF ABQXT ABRHV ABUWG ABVFX ABXGC ABYTW ACARO ACDSZ ACDXX ACFEJ ACFMA ACFYK ACGBL ACGFO ACGFS ACGZU ACJTF ACLFY ACLHI ACLZU ACOFE ACOXC ACROE ACSBE ACSIQ ACTQU ACUAV ACUIR ACXKE ACXMB ADBBV ADEIA ADMPF ADNBR ADRRZ ADTBJ ADUKL ADZCM ADZZY AECGH AECVZ AEDTQ AEGXH AEKYL AENEX AEPTA AEQLS AERKM AESZF AEUHG AEUIJ AEWDL AEWHI AEXFG AEXNY AFEET AFKBI AFKRA AFKRG AFMOU AFQAA AFUIA AGKLV AGNHF AGWFA AHHFK AHMBA AIAGR AIGRN AIOMO AJABX AJEFB AJMMQ AJSCY AJUZI AJXAJ ALIPV ALJHS ALMA_UNASSIGNED_HOLDINGS ALTZF AMCVQ ANDLU ARTOV ASPBG AUTPY AUVAJ AVWKF AYAKG AZFZN B3H B8M B8O B8R B8Z B93 B94 BBRGL BDDNI BENPR BKIIM BKSCU BPACV BPHCQ BSEHC BVXVI BWJAD BYIEH C1A C45 CAG CBRKF CCPQU CDWPY CFDXU COF CORYS CQQTX CS3 CUTAK DB0 DC- DC. DC0 DD- DD0 DE- DF0 DO- DOPDO DV7 DV9 D~Y EBD EBS EJD EMB EMOBN F5P FEDTE FHBDP FYUFA GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION HF~ HMCUK HVGLF HZ~ J8X JCYGO K.F K.J M1P M4V N9A O9- OBH OHH OVD P.B P2P PQQKQ PROAC PSQYO Q1R Q2X Q7K Q7L Q7R Q7U Q7X Q82 Q83 ROL RWL RXW S01 SCNPE SDB SFB SFC SFK SFN SFT SGA SGO SGP SGR SGV SGX SGZ SHG SNB SPJ SPQ SPV SQCSI STM SV3 TAE TEORI UKHRP WH7 X6Y X7M XDU YFH YOC ZGI ZONMY ZPPRI ZRKOI ZSSAH ZXP ZY1 ACJER AGWNL ALKWR CGR CUY CVF ECM EIF H13 NPM AAYXX CITATION 7XB 8FK K9. PQEST PQUKI PRINS 7X8 |
ID | FETCH-LOGICAL-c432t-e4d158a992d1399a331413124ab70ad63ff03a0c837b9b24a4f7fee5403802fc3 |
IEDL.DBID | 7X7 |
ISSN | 0003-3197 |
IngestDate | Thu Aug 15 22:25:55 EDT 2024 Thu Oct 10 19:32:41 EDT 2024 Wed Sep 18 12:52:55 EDT 2024 Tue Oct 15 23:25:35 EDT 2024 Tue Jul 16 20:43:48 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 8 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c432t-e4d158a992d1399a331413124ab70ad63ff03a0c837b9b24a4f7fee5403802fc3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
PMID | 10959513 |
PQID | 224825449 |
PQPubID | 33739 |
ParticipantIDs | proquest_miscellaneous_72206897 proquest_journals_224825449 crossref_primary_10_1177_000331970005100809 pubmed_primary_10959513 sage_journals_10_1177_000331970005100809 |
PublicationCentury | 2000 |
PublicationDate | 2000-08-01 |
PublicationDateYYYYMMDD | 2000-08-01 |
PublicationDate_xml | – month: 08 year: 2000 text: 2000-08-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Thousand Oaks, CA |
PublicationPlace_xml | – name: Thousand Oaks, CA – name: United States – name: Thousand Oaks |
PublicationTitle | Angiology |
PublicationTitleAlternate | Angiology |
PublicationYear | 2000 |
Publisher | SAGE Publications SAGE PUBLICATIONS, INC |
Publisher_xml | – name: SAGE Publications – name: SAGE PUBLICATIONS, INC |
References | Delius M. 1995; 120 European Working Group on Critical Leg Ischemia. 1991; 84 Belcaro G., Nicolaides AN, Cesarone MR 1999; 50 Belcaro G., Nicolaides AN, Cipollone G. 2000; 51 Caspari GH, Erbel R. 1999; 100 Belcaro G., Nicolaides AN 1998; 46 Belcaro G., Veller M., Nicolaides AN 1998; 49 Belcaro G., Laurora G., Nicolaides AN 1998; 49 Heidrich H., Allanberg J., Cachovan M. 1992; 21 European Working Group on Critical Leg Ischemia. (atypb6) 1991; 84 atypb8 Belcaro G. (atypb11) 1998; 46 Delius M. (atypb1) 1995; 120 Caspari GH (atypb3) 1999; 100 Cesarone MR (atypb4) 1998 Heidrich H. (atypb7) 1992; 21 atypb2 atypb10 atypb5 Belcaro G (atypb9) 1996 |
References_xml | – volume: 120 start-page: 259 year: 1995 end-page: 273 article-title: Biological effect of shock-waves—more than just lithotripsy publication-title: Zentralbl Chir contributor: fullname: Delius M. – volume: 50 start-page: 707 year: 1999 end-page: 713 article-title: Shock waves (SW) noninvasive extracorporeal thrombolysis treatment (NISWT) publication-title: Angiology contributor: fullname: Cesarone MR – volume: 49 start-page: 885 year: 1998 end-page: 895 article-title: Treatment of severe intermittent claudication with PGE 1. A short-term vs long-term infusion plan. A 20-week, European, randomized trial. Analysis of efficacy and costs publication-title: Angiology contributor: fullname: Nicolaides AN – volume: 100 start-page: 84 issue: 18 year: 1999 article-title: Revascularisation with extracorporeal cardiac shock wave therapy publication-title: Circulation contributor: fullname: Erbel R. – volume: 84 start-page: 1 issue: 4 year: 1991 article-title: Second European Consensus publication-title: Circulation contributor: fullname: European Working Group on Critical Leg Ischemia. – volume: 21 start-page: 339 year: 1992 end-page: 343 article-title: Guidelines for therapeutic studies on peripheral arterial occlusive disease in Fontaine stages II-IV publication-title: Vasa contributor: fullname: Cachovan M. – volume: 49 start-page: 673 year: 1998 end-page: 706 article-title: Noninvasive investigations in vascular disease publication-title: Angiology contributor: fullname: Nicolaides AN – volume: 51 start-page: 3 issue: 1 year: 2000 end-page: 14 article-title: Nomograms used to define the short-term treatment with PGE 1 in patients with intermittent claudication and critical limb ischemia. The ORACLE (occlusion revascularization in the atherosclerotic critical limb) study group. The European study publication-title: Angiology contributor: fullname: Cipollone G. – volume: 46 start-page: 1 issue: 1 year: 1998 end-page: 8 article-title: Planning of clinical trials evaluating treatments in peripheral vascular disease due to atherosclerosis publication-title: Minerva Cardioangiol contributor: fullname: Nicolaides AN – volume: 46 start-page: 1 issue: 1 year: 1998 ident: atypb11 publication-title: Minerva Cardioangiol contributor: fullname: Belcaro G. – volume: 120 start-page: 259 year: 1995 ident: atypb1 publication-title: Zentralbl Chir contributor: fullname: Delius M. – ident: atypb2 doi: 10.1177/000331979905000903 – volume-title: Laser Doppler year: 1996 ident: atypb9 contributor: fullname: Belcaro G – volume: 84 start-page: 1 issue: 4 year: 1991 ident: atypb6 publication-title: Circulation contributor: fullname: European Working Group on Critical Leg Ischemia. – volume-title: Malattie Vascolari periferiche year: 1998 ident: atypb4 contributor: fullname: Cesarone MR – ident: atypb5 doi: 10.1177/000331979804901103 – volume: 100 start-page: 84 issue: 18 year: 1999 ident: atypb3 publication-title: Circulation contributor: fullname: Caspari GH – volume: 21 start-page: 339 year: 1992 ident: atypb7 publication-title: Vasa contributor: fullname: Heidrich H. – ident: atypb8 doi: 10.1177/000331970005100802 – ident: atypb10 doi: 10.1177/000331979804901001 |
SSID | ssj0005106 |
Score | 1.6608249 |
Snippet | Shock waves (SWs) are used to control and decrease pain in several clinical conditions (eg, painful elbow and shoulder, etc). This clinical effect may be due... Shock waves (SWs) are used to control and decrease pain in several clinical conditions (e.g., painful elbow and shoulder, etc). This clinical effect may be due... |
SourceID | proquest crossref pubmed sage |
SourceType | Aggregation Database Index Database Publisher |
StartPage | S69 |
SubjectTerms | Aged Female High-Energy Shock Waves Humans Ischemia - complications Ischemia - pathology Ischemia - therapy Leg - blood supply Leg - pathology Male Microcirculation Middle Aged Necrosis Pain - etiology Pain Management Pain Measurement Severity of Illness Index Treatment Outcome |
Title | Effects of Shock Waves on the Microcirculation in Critical Limb Ischemia (CLI) (8-Week Study) |
URI | https://journals.sagepub.com/doi/full/10.1177/000331970005100809 https://www.ncbi.nlm.nih.gov/pubmed/10959513 https://www.proquest.com/docview/224825449 https://search.proquest.com/docview/72206897 |
Volume | 51 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8QwEB50BfEivq3rIwcPK1Jsm75yEl0UFRURhb1ISdoEi2533e66f99Jm_pA9Ni0tOnMdL5vmskMwD5SViYyhcYbZIHtB0LanAuMWp1McTeOQ1XVLbi5DS8e_ate0DO5OaVJq2x8YuWos0Gq_5EfIdToYMZnx8M3WzeN0ourpoPGLMy5HnIJNOeoF31leLhVa01N-9HVsKjZMxNVNRupHqqvQtbEfuLSL7L5I9Grwp7zJVg0pJGc1FpehhlZrMD8jVkWX4WnugZxSQaKlM_o4ciUv0s8LAjyO9LXSXdpPkpNqy6SFyQ1LQ7Ia94XJMcYV_ZzTjrd68sD0ontqZQvpKo9e7AGj-dnD90L2_RNsFOfemNb-pkbxJwxL0N-xzi-KUIVAjkXkcOzkCrlUO6kGJsKJnDYV5GSErkbjR1PpXQdWsWgkJtAYh0QZYEXKokwJqlAb6i8WDAn9XlAuQWHjdSSYV0eI3GbCuK_ZGxBuxFsYj6VMvlUrAV7n2fRxvXCBS_kYFImkec5YcwiCzZqbXx7FguQI1ILOlo9X3f9exJb_06iDQv1Znud4rcNrfFoIneQdozFbmVcuzB3enZ7d_8B1O7PqA |
link.rule.ids | 315,786,790,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838,74100,74657 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8MwDLZ4SMAF8aaMRw4chlBF16SPnBBCoA02TiDtgqqkTUQF6wYd8Pdx2pSHEBybVm1qu_4-N44NcIiUlctMo_EGWeCyQCpXCIlRq5dp0YnjUFd1CwY3YfeOXQ2Doc3NKW1aZeMTK0edjVPzj_wEocYEM4yfTp5d0zTKLK7aDhqzMM8oZcbMo2H0leHRqVprGtqProZHzZ6ZqKrZSM1QfRWyJv4Tl36RzR-JXhX2XK7AsiWN5KzW8irMqGINFgZ2WXwd7usaxCUZa1I-oIcj7-JN4WFBkN-RkUm6S_OX1LbqInlBUtvigDzlI0lyjHHVKBekfd7vHZF27L4r9Uiq2rNHG3B3eXF73nVt3wQ3ZdSfuoplnSAWnPsZ8jsu8E0RqhDIhYw8kYVUa48KL8XYVHKJw0xHWinkbjT2fJ3STZgrxoXaBhKbgCgL_FArhDFFJXpD7ceSeykTARUOHDdSSyZ1eYyk01QQ_yVjB1qNYBP7qZTJp2IdOPg8izZuFi5EocavZRL5vhfGPHJgq9bGt2fxADkidaBt1PN1178nsfPvJA5gsXs76Cf93s11C5bqjfcm3W8X5qYvr2oPKchU7leG9gExkdD7 |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8MwDLZ4SIgL4k155sBhCFXrmr5yQgiYBgzEgUm7oCppE1HBurEO-Ps4bcpAExybVm1qu_4-N44NcIyUlYlUofH6qW97vpA25wKjVidVvBVFgSrrFtzdB52ed9P3-6akUGHSKmufWDrqdJjof-RNhBodzHisqUxWxMNl-2z0ZusGUnqh1XTTmIdFBElHd3EI--E026NVttnUIQC6HRbW-2fCsn4j1UPVVcig2G-MmiGev5K-Shxqr8KKIZDkvNL4GszJfB2W7swS-QY8VfWICzJUpHhGb0c--YfEw5wg1yMDnYCXZOPEtO0iWU4S0-6AvGYDQTKMd-Ug46Rx0b0-IY3I_pTyhZR1aE82ode-erzo2KaHgp141J3Y0ktbfsQZc1PkeozjmyJsIahzETo8DahSDuVOgnGqYAKHPRUqKZHH0chxVUK3YCEf5nIHSKSDo9R3AyUR0iQV6BmVGwnmJB73KbfgtJZaPKpKZcStupr4jIwt2KsFG5vPpoi_lWzB0fdZtHe9iMFzOXwv4tB1nSBioQXblTZ-PIv5yBepBQ2tnuld_57E7r-TOIIltLG4e31_uwfL1R58nfm3DwuT8bs8QDYyEYelnX0BQX3VJw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+Shock+Waves+on+the+Microcirculation+in+Critical+Limb+Ischemia+%28CLI%29+%288-Week+Study%29&rft.jtitle=Angiology&rft.au=De+Sanctis%2C+M.T.&rft.au=Belcaro%2C+G.&rft.au=Nicolaides%2C+A.N.&rft.au=Cesarone%2C+M.R.&rft.date=2000-08-01&rft.pub=SAGE+Publications&rft.issn=0003-3197&rft.eissn=1940-1574&rft.volume=51&rft.issue=8&rft.spage=S69&rft.epage=S78&rft_id=info:doi/10.1177%2F000331970005100809&rft.externalDocID=10.1177_000331970005100809 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-3197&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-3197&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-3197&client=summon |